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Chemical Structure| 57371-37-6 Chemical Structure| 57371-37-6

Structure of 57371-37-6

Chemical Structure| 57371-37-6

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Product Details of [ 57371-37-6 ]

CAS No. :57371-37-6
Formula : C5H9NO
M.W : 99.13
SMILES Code : N#CCCCOC
MDL No. :MFCD09930022

Safety of [ 57371-37-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335-H227
Precautionary Statements:P210-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 57371-37-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57371-37-6 ]

[ 57371-37-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57371-37-6 ]
  • [ 29006-02-8 ]
YieldReaction ConditionsOperation in experiment
To a stirred solution of 4-methoxybutyronitrile was added dropwise a solution of potassium hydroxide (22 g) in water (220 ml). Upon complete addition, the reaction was heated to reflux temperature and held at this temperature overnight. The reaction mixture was then cooled to RT, and the pH adjusted to pH 2 by the addition of 2M HCI. The reaction mixture was then extracted into ethyl acetate (2 x 500 ml). The combined organics were dried over magnesium sulfate, filtered and concentrated in vacuo. Purification by silica gel column chromatography (1: 1 ethyl acetate/hexane) gave the required material as a colourless oil (10.2 g, 62% over 2 steps).
 

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