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Chemical Structure| 57489-59-5 Chemical Structure| 57489-59-5

Structure of 57489-59-5

Chemical Structure| 57489-59-5

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Product Details of [ 57489-59-5 ]

CAS No. :57489-59-5
Formula : C13H17NO2
M.W : 219.28
SMILES Code : O=C(OC)C1=CC=CC(N2CCCCC2)=C1
MDL No. :MFCD06740037

Safety of [ 57489-59-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 57489-59-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57489-59-5 ]

[ 57489-59-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-89-4 ]
  • [ 2905-65-9 ]
  • [ 57489-59-5 ]
YieldReaction ConditionsOperation in experiment
70% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); P(i-BuNCH2)3CMe; In toluene; at 110℃; for 24h;Product distribution / selectivity; Pd(OAc)2 or Pd2(dba)3/2-Catalyzed Amination of Aryl chlorides (Table 5).General Procedure: An oven-dried Schlenk flask equipped with a magnetic stirring bar was charged with Pd(OAc)2 or Pd2(dba)3 (x mol %, see Table 5) and NaO-t-Bu (1.5 mmol) or Cs2CO3 (1.5 mmol). Amine (1.2 mmol) and aryl chloride (1.0 mmol) were also added at this time if they were solids. The flask was capped with a rubber septum, evacuated and then flushed with argon. This cycle was repeated three times. Ligand 2 (2x mol %, see Table 5) was then added via syringe from a stock solution. Aryl chloride (if a liquid, 1.0 mmol), amine (if a liquid, 1.2 mmol) and toluene (3 mL) were then successively added by syringe. The reaction mixture was heated at 110 C. until the starting material had been completely consumed as judged by TLC (24 hours). The mixture was cooled to room temperature, adsorbed onto silica gel and then purified by column chromatography (hexanes/ethyl acetate as eluent).
 

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