[ CAS No. 5851-49-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 5851-49-0
Chemical Structure| 5851-49-0
Structure of 5851-49-0

Quality Control of [ 5851-49-0 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 5851-49-0 ]

SDS

Product Details of [ 5851-49-0 ]

CAS No. :5851-49-0MDL No. :MFCD00459384
Formula :C14H20N2Boiling Point :392.2°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :216.32Pubchem ID :-
Synonyms :

Computed Properties of [ 5851-49-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 5851-49-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5851-49-0 ]

  • Downstream synthetic route of [ 5851-49-0 ]

[ 5851-49-0 ] Synthesis Path-Downstream   1~10

YieldReaction ConditionsOperation in experiment
77% With potassium tert-butylate; In toluene; at 120℃; for 12h;Sealed tube; General procedure: A method for preparing a benzimidazole compound by oxidative coupling dehydrogenation of 1,2-phenylenediamine and benzyl alcohol by using a nitrogen-phosphorus-doped carbon material-supported nickel catalyst prepared in Example 1. The steps are: 0.2 mmol of 1,2-phenylenediamine, 0.2 mmol of benzyl alcohol, 30 mg of the supported catalyst, 2 mL of toluene, 6.72 mg (0.06 mmol) of potassium t-butoxide, and the reaction is carried out at 120 C after sealing. After 12 hours, it was cooled to room temperature, and the reaction solution was filtered, and silica gel column chromatography gave 2-phenyl-1 hydrogen-benzimidazole compound;
  • 4
  • [ 5851-49-0 ]
  • 2-heptyl-1,3-bis(naphthalen-2-ylmethyl)benzimidazolium bromide [ No CAS ]
  • 5
  • [ 5851-49-0 ]
  • [ 939-26-4 ]
  • C25H28N2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
2-Heptyl-benzimidazole (0.09 g, 0.42 mmol) was dissolved in acetonitrile (5 mL), potassium hydroxide (0.03 g, 0.53 mmol) was added and the mixture was refluxed for 30 min. 2-(Bromomethyl)naphthalene (0.11 g, 0.50 mmol) was added and the mixture was refluxed overnight.
  • 6
  • [ 95-54-5 ]
  • [ 111-64-8 ]
  • [ 5851-49-0 ]
YieldReaction ConditionsOperation in experiment
42% Reflux; General procedure: To0.5 g (4.62 mmol) of 1,2-phenylendiamine were addeddropwise the respective acyl chloride (9.25 mmol) withstirring. The mixture was subsequently heated to reflux until the solutionbecame clear. After 2h, the reaction is finished and the product was purifiedby column chromatography on silica gel with methylene chloride/methanol (9:1) andrecrystallization from diethyl ether/methanol.
  • 7
  • [ 5851-49-0 ]
  • [ 114772-54-2 ]
  • 4‘-((2-heptyl-1H-benz[d]imidazol-1-yl)methyl)-[1,1‘-biphenyl]-2-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
52% With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20℃; for 3h;Cooling with ice; General procedure: The respective 1H-benz[d]imidazole(2.50 mmol) was dissolved in 10 ml of abs. DMF. Sodium hydride(60 % dispersion in mineral oil) (0.2 g, 5 mmol) was added withcooling. After the gas formation stopped, 4?-bromomethyl-[1,1?-biphenyl]-2-carbonitrildissolved in 2 ml of abs. DMF was added dropwise and the solution wasstirred for 1 h under cooling in an ice bath and further 2h at RT. Water wasadded and after the solution was acidified with HCl the product was extractedthree times with methylene chloride. The combined organic layers were driedover Na2SO4 and evaporated to dryness in vacuo. The crudeproduct was purified by column chromatography on silica gel with methylenechloride/methanol (95:5) and if necessary recrystallized from diethyl ether/methanol.
  • 8
  • [ 5851-49-0 ]
  • 4'-((2-heptyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbamide [ No CAS ]
  • 9
  • [ 5851-49-0 ]
  • 4'-((2-heptyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid [ No CAS ]
  • 10
  • [ 95851-34-6 ]
  • [ 95-54-5 ]
  • [ 5851-49-0 ]
YieldReaction ConditionsOperation in experiment
59% With iron(III) nitrate nonahydrate; In acetonitrile; at 80℃; for 12h; General procedure: A mixture of 1.5 mmol o-phenylenediamine, and 1 mmol imine, 5 mol% Fe(NO3)3·9H2O, and 5 ml MeCN were mixed in a 10 ml three-necked flask, one necked is equiped with a condenser, another is equiped with a thermometer with a condenser, and then stirred rapidiy open to air at 80C for 12 hours. The reaction progress was monitored by TLC. After completion of the reaction, the residue was directly purified by column chromatograph on a silica gel using hexane/ethyl acetate (7:3) as eluent to afford the pure product.
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