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Chemical Structure| 59079-75-3 Chemical Structure| 59079-75-3

Structure of 59079-75-3

Chemical Structure| 59079-75-3

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Product Details of [ 59079-75-3 ]

CAS No. :59079-75-3
Formula : C10H6FI
M.W : 272.06
SMILES Code : IC1=CC2=CC=C(F)C=C2C=C1

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Application In Synthesis of [ 59079-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59079-75-3 ]

[ 59079-75-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 324-41-4 ]
  • [ 59079-75-3 ]
YieldReaction ConditionsOperation in experiment
Stage 9.1 (0291) (0292) 80 n-Butyllithium solution (1.6 M in 81 hexane, 115.00 ml, 195.51 mmol) is added to the solution of 82 <strong>[324-41-4]2-bromo-6-fluoro-naphthalene</strong> (20.00 g, 88.87 mmol) in 300 ml ether at -78 C. The mixture is stirred at -78 C. for 1 h and a solution of 83 iodine (27.07 g, 106.64 mmol) in ether (100 ml) is added via cannula. The mixture is warmed to ambient temperature over a period of approximately 1 h, quenched with saturated aqueous solution of 84 ammonium chloride, washed with saturated aqueous Sodium thiosulfate, washed with water and brine, dried over magnesium sulphate and concentrated under reduced pressure.(0293) The residue is purified via flash chromatography using 85 petroleum ether to give 86 2-fluoro-6-iodo-naphthalene
 

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