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Chemical Structure| 5998-89-0 Chemical Structure| 5998-89-0

Structure of 5998-89-0

Chemical Structure| 5998-89-0

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Product Details of [ 5998-89-0 ]

CAS No. :5998-89-0
Formula : C8H6N2O
M.W : 146.15
SMILES Code : C1(C2=NC=CO2)=NC=CC=C1
MDL No. :MFCD18254207

Safety of [ 5998-89-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 5998-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5998-89-0 ]

[ 5998-89-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-04-6 ]
  • [ 145214-05-7 ]
  • [ 5998-89-0 ]
YieldReaction ConditionsOperation in experiment
67% tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; for 24h;Heating; Reflux; Inert atmosphere of Ar; 2-(Tributylstannyl)oxazole (1.00 g, 2.79 mmol), (Ph3P)4Pd (0.1 equiv), and 2-bromopyridine (2 equiv) were dissolved in anhydrous 1,4-dioxane (15 raL) and the mixture was warmed at reflux for 24 h under Ar. The mixture was diluted with EtOAc, washed with saturated aqueous NaCl and dried over Na2SO4. Evaporation in vacuo yielded the crude product that was purified by flash chromatography (SiO2, 10-60% EtOAc-hexanes) to yield the title compound (275 mg, 67%) as a light yellow oil: 1H NMR (CDCl3, 500 MHz) δ 8.63 (m, IH), 8.04 (d, IH, J= 7.5 Hz), 7.73-7.70 (m, 2H), 7.26-7.22 (m, 2H); 13C NMR (CDCl3, 125 MHz) δ 161.0, 150.2, 146.4, 140.1, 137.3, 129.1, 125.0, 122.3.
 

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