Structure of 6-Aminocaproic acid
CAS No.: 60-32-2
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
6-Aminocaproic Acid inhibits the plasmin activating enzymes streptokinase, fibrinokinase and urokinase, it is an antifibrinolytic agent.
Synonyms: EACA; Epsilon-Amino-n-caproic Acid; Hepin
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| CAS No. : | 60-32-2 |
| Formula : | C6H13NO2 |
| M.W : | 131.17 |
| SMILES Code : | O=C(O)CCCCCN |
| Synonyms : |
EACA; Epsilon-Amino-n-caproic Acid; Hepin
|
| MDL No. : | MFCD00008238 |
| InChI Key : | SLXKOJJOQWFEFD-UHFFFAOYSA-N |
| Pubchem ID : | 564 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
| Description |
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, acts as a potent oral inhibitor of plasmin and plasminogen. It serves as a powerful antifibrinolytic agent by preventing clot lysis through competitive binding to lysine residues on plasminogen, inhibiting plasmin formation, and thereby reducing fibrinolysis. This compound is researched for use in treating bleeding disorders[1].[2].
|
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT01968070 | Healthy Volunteers | Phase 1 | Completed | - | United States, Indiana ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 Less << |
| NCT03364491 | Obstetrical Complications ... More >> Hemorrhage Labor and Delivery Less << | Phase 3 | Recruiting | December 2020 | United States, Alabama ... More >> University of Alabama - Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Stacy Harris, BSN 205-996-6262 stacylharris@uabmc.edu Principal Investigator: Alan TN Tita, MD United States, Illinois Northwestern University-Prentice Hospital Recruiting Chicago, Illinois, United States, 60611 Contact: Gail Mallett, RN BSN CCRC 312-503-3200 g-mallett@northwestern.edu Principal Investigator: William Grobman, MD United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Sabine Bousleiman 212-305-4348 sb1080@columbia.edu Principal Investigator: Cynthia Gyamfi-Bannerman, MD United States, North Carolina University of North Carolina - Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Kelly Clark, RN 919-350-6117 kelly_clark@med.unc.edu Principal Investigator: John M Thorp, Jr., MD United States, Ohio Case Western Reserve-MetroHealth Recruiting Cleveland, Ohio, United States, 44109 Contact: Wendy Dalton, RN 216-778-7533 wdalton@metrohealth.org Principal Investigator: Edward Chien, MD Ohio State University Hospital Recruiting Columbus, Ohio, United States, 43210 Contact: Anna Bartholomew, RN, BSN 614-685-3229 anna.bartholomew@osumc.edu Principal Investigator: Catalin S Buhimschi, MD United States, Pennsylvania Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Jennifer Craig, BSN 212-662-3926 jennifer.craig@uphs.upenn.edu Principal Investigator: Samuel Parry, MD Magee Women's Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Melissa Bickus, BS, RN 412-641-4072 mbickus@mail.magee.edu Principal Investigator: Hyagriv Simhan, MD, MS United States, Rhode Island Brown University Recruiting Providence, Rhode Island, United States, 02905 Contact: Donna Allard, RNC 401-274-1122 dallard@wihri.org Principal Investigator: Dwight J Rouse, MD United States, Texas University of Texas Medical Branch Recruiting Galveston, Texas, United States, 77555 Contact: Ashley Salazar, MSN 409-772-0312 assalaza@utmb.edu Principal Investigator: George R Saade, MD University of Texas - Houston Recruiting Houston, Texas, United States, 77030 Contact: Felecia Ortiz, RN BSN 713-500-6467 Felecia.Ortiz@uth.tmc.edu Principal Investigator: Suneet Chauhan, MD United States, Utah University of Utah Medical Center Recruiting Salt Lake City, Utah, United States, 84132 Contact: Kim Hill, RN 801-585-7645 Kim.Hill@hsc.utah.edu Principal Investigator: Michael W Varner, MD Less << |
| NCT01428713 | Menorrhagia | Not Applicable | Completed | - | United States, Texas ... More >> Baylor College of Medicine Houston, Texas, United States, 77030 Less << |
| NCT02911233 | - | Completed | - | France ... More >> University Hospital Caen, Calvados, France, 14000 Less << | |
| NCT01428713 | - | Completed | - | - | |
| NCT03710304 | Cesarean Section Complications | Not Applicable | Recruiting | June 1, 2020 | Egypt ... More >> Aswan University Recruiting Aswan, Egypt, 81528 Contact: hany f sallam, md 01092440504 ext 002 nahla.elsayed@aswu.ed.eg Less << |
| NCT02678208 | Postpartum Hemorrhage | Phase 2 | Completed | - | Egypt ... More >> Assiut university Assiut, Egypt, 71111 Less << |
| NCT00405093 | - | Completed | - | United States, New York ... More >> The New York Presbyterian Hospital - Weill Medical College of Cornell University New York, New York, United States, 10021 Less << | |
| NCT02616042 | Labor Trial Refused | Phase 3 | Completed | - | - |
| NCT02352675 | - | Completed | - | United States, Massachusetts ... More >> Boston Children's Hospital Boston, Massachusetts, United States, 02115 Less << | |
| NCT00752024 | Hypertensive Intracerebral Hem... More >>orrhage Less << | Not Applicable | Unknown | December 2010 | China, Hubei ... More >> Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology Not yet recruiting Wuhan, Hubei, China, 430030 Contact: wei wang, doctor 86-027-8366-3648 daodetongji@163.com Contact: zhouping tang, doctor 86-013971616328 ddjtzp@163.com Principal Investigator: wei wang, doctor Less << |
| NCT01971684 | - | Completed | - | - | |
| NCT00156520 | Hemorrhage | Phase 4 | Completed | - | United States, New York ... More >> Strong Memorial Hospital, University of Rochester Rochester, New York, United States, 14642 Less << |
| NCT00223704 | Cardiopulmonary Bypass ... More >> Inflammation Fibrinolysis Surgery Less << | Phase 2 Phase 3 | Completed | - | United States, Tennessee ... More >> TN Valley Healthcare System Nashville, Tennessee, United States, 37212 Vanderbilt University Nashville, Tennessee, United States, 37232 Less << |
| NCT01981863 | Pathologic Fibrinolysis | Phase 4 | Completed | - | United States, California ... More >> Stanford Hospital & Clinics Stanford, California, United States, 94305 Less << |
| NCT00617955 | - | Completed | - | United States, New York ... More >> SUNY Upstate Medical University Syracuse, New York, United States, 13210 Less << | |
| NCT00940745 | Hypertensive Intracerebral Hem... More >>orrhage Less << | Not Applicable | Unknown | March 2010 | China, Hubei ... More >> Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology Not yet recruiting Wuhan, Hubei, China, 430030 Contact: wei wang, doctor 86-027-8366-3648 daodetongji@163.com Contact: zhouping tang, doctor 86-013971616328 ddjtzp@163.com Principal Investigator: wei wang, doctor Less << |
| NCT01248104 | Cardiopulmonary Bypass | Not Applicable | Unknown | February 2015 | United States, California ... More >> Loma Linda University Medical Center Loma Linda, California, United States, 92354 Less << |
| NCT02238288 | Oral Hemorrhage | Phase 4 | Unknown | July 2015 | Brazil ... More >> Clementino Fraga Filho University Hospital Rio de Janeiro, RJ, Brazil, 21864-440 Less << |
| NCT01408823 | - | Completed | - | United States, Pennsylvania ... More >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less << | |
| NCT00223704 | - | Completed | - | - | |
| NCT00320619 | Scoliosis Kyp... More >>hosis Lordosis Spondylitis Spinal Stenosis Less << | Not Applicable | Completed | - | United States, Maryland ... More >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 Less << |
| NCT01981863 | - | Completed | - | - | |
| NCT00958581 | - | Completed | - | - | |
| NCT01527968 | Osteoarthritis | Not Applicable | Unknown | December 2016 | - |
| NCT00958581 | Scoliosis | Phase 4 | Completed | - | United States, New York ... More >> New York University School of Medicine - Department of Orthopaedic Surgery - Spine New York, New York, United States, 10016 Less << |
| NCT01398280 | Rosacea | Early Phase 1 | Completed | - | United States, California ... More >> University of California, San Diego Perlman Ambulatory Center La Jolla, California, United States, 92037 Less << |
| NCT03365999 | Knee Osteoarthritis ... More >> Blood Clot Transfusion Related Complication Blood Loss Less << | Phase 2 | Recruiting | December 15, 2018 | Mexico ... More >> Facultad de Medicina UANL Recruiting Monterrey, Nuevo Leon, Mexico, 1-4469 Contact: Felix Vilchez, MD, PHD fvc78@hotmail.com Contact: Rodolfo Morales-Avalos, MD 005218115557776 rodolfot59@hotmail.com Less << |
| NCT02655653 | Bleeding | Not Applicable | Completed | - | - |
| NCT00912119 | Craniosynostosis | Phase 1 | Completed | - | United States, Pennsylvania ... More >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less << |
| NCT02030821 | - | Completed | - | - | |
| NCT02030821 | Blood Loss Hi... More >>p Arthritis Knee Arthritis Less << | Phase 4 | Completed | - | United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27708 Less << |
| NCT01391182 | Degenerative Joint Disease ... More >> Osteoarthritis Less << | Not Applicable | Completed | - | United States, Florida ... More >> Mayo Clinic Jacksonville Jacksonville, Florida, United States, 32224 Less << |
| NCT02639819 | Intracerebral Hemorrhage | Phase 1 | Withdrawn(Study was withdrawn ... More >>from IRB review on 03/08/16) Less << | December 2017 | - |
| NCT02229968 | Craniosynostosis | Phase 2 | Active, not recruiting | December 2019 | United States, District of Col... More >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 Less << |
| NCT02074436 | Hematological Malignancies ... More >> Thrombocytopenia Less << | Phase 2 | Recruiting | May 2019 | United States, Georgia ... More >> Emory University Hospital Recruiting Atlanta, Georgia, United States, 30322 Contact: Ana Antun, MD, MSc 404-593-6732 ana.antun@emoryhealthcare.org Principal Investigator: Ana G. Antun, MD, MSc Atlanta VA Medical Center Recruiting Decatur, Georgia, United States, 30033 Contact: Ana Antun, MD, MSc 404-593-6732 ana.antun@emoryhealthcare.org Principal Investigator: Wayne B. Harris, MD Less << |
| NCT02656472 | Pediatric Cardiac Surgery ... More >> Complication of Extracorporeal Circulation Less << | Phase 4 | Completed | - | United States, Illinois ... More >> Advocate Childrens Hospital Oak Lawn, Illinois, United States, 60453 Less << |
| NCT01873768 | Osteoarthritis | Phase 4 | Completed | - | United States, Iowa ... More >> Miller Orthopedic Specialists Council Bluffs, Iowa, United States, 51503 Less << |
| NCT01965730 | Aortic Disease | Early Phase 1 | Terminated(the study was suspe... More >>nded due to shortage of the study drug (amicar).) Less << | - | United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
| NCT02257580 | E-Aminocaproic Acid ... More >> Bilateral Varus Rotational Osteotomy Less << | Phase 4 | Recruiting | January 2020 | United States, New York ... More >> Hospital for Special Surgery Recruiting New York, New York, United States, 10021 Contact: David Scher, MD 212-606-1253 scherd@hss.edu Contact: Emily Dodwell, MD MPH 212-606-1451 dodwelle@hss.edu Sub-Investigator: Ishaan Swarup, MD Less << |
| Bio Calculators | ||||
| Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
7.62mL 1.52mL 0.76mL |
38.12mL 7.62mL 3.81mL |
76.24mL 15.25mL 7.62mL |
|
| Dissolving Methods |
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
|
|||
Tags: 6-Aminocaproic acid | EACA | Epsilon-Amino-n-caproic Acid | 6-Aminohexanoic acid | plasmin | plasminogen | antifibrinolytic | lysis | fibrinolysis | bleeding | 60-32-2 |
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| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
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| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
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| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
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Health hazards | |
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| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
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| H314 | Causes severe skin burns and eye damage |
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| H318 | Causes serious eye damage |
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| H335 | May cause respiratory irritation |
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| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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