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Chemical Structure| 60-32-2 Chemical Structure| 60-32-2

Structure of 6-Aminocaproic acid
CAS No.: 60-32-2

Chemical Structure| 60-32-2

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6-Aminocaproic Acid inhibits the plasmin activating enzymes streptokinase, fibrinokinase and urokinase, it is an antifibrinolytic agent.

Synonyms: EACA; Epsilon-Amino-n-caproic Acid; Hepin

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Product Details of 6-Aminocaproic acid

CAS No. :60-32-2
Formula : C6H13NO2
M.W : 131.17
SMILES Code : O=C(O)CCCCCN
Synonyms :
EACA; Epsilon-Amino-n-caproic Acid; Hepin
MDL No. :MFCD00008238
InChI Key :SLXKOJJOQWFEFD-UHFFFAOYSA-N
Pubchem ID :564

Safety of 6-Aminocaproic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, acts as a potent oral inhibitor of plasmin and plasminogen. It serves as a powerful antifibrinolytic agent by preventing clot lysis through competitive binding to lysine residues on plasminogen, inhibiting plasmin formation, and thereby reducing fibrinolysis. This compound is researched for use in treating bleeding disorders[1].[2].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01968070 Healthy Volunteers Phase 1 Completed - United States, Indiana ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 Less <<
NCT03364491 Obstetrical Complications ... More >> Hemorrhage Labor and Delivery Less << Phase 3 Recruiting December 2020 United States, Alabama ... More >> University of Alabama - Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Stacy Harris, BSN    205-996-6262    stacylharris@uabmc.edu    Principal Investigator: Alan TN Tita, MD          United States, Illinois Northwestern University-Prentice Hospital Recruiting Chicago, Illinois, United States, 60611 Contact: Gail Mallett, RN BSN CCRC    312-503-3200    g-mallett@northwestern.edu    Principal Investigator: William Grobman, MD          United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Sabine Bousleiman    212-305-4348    sb1080@columbia.edu    Principal Investigator: Cynthia Gyamfi-Bannerman, MD          United States, North Carolina University of North Carolina - Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Kelly Clark, RN    919-350-6117    kelly_clark@med.unc.edu    Principal Investigator: John M Thorp, Jr., MD          United States, Ohio Case Western Reserve-MetroHealth Recruiting Cleveland, Ohio, United States, 44109 Contact: Wendy Dalton, RN    216-778-7533    wdalton@metrohealth.org    Principal Investigator: Edward Chien, MD          Ohio State University Hospital Recruiting Columbus, Ohio, United States, 43210 Contact: Anna Bartholomew, RN, BSN    614-685-3229    anna.bartholomew@osumc.edu    Principal Investigator: Catalin S Buhimschi, MD          United States, Pennsylvania Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Jennifer Craig, BSN    212-662-3926    jennifer.craig@uphs.upenn.edu    Principal Investigator: Samuel Parry, MD          Magee Women's Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Melissa Bickus, BS, RN    412-641-4072    mbickus@mail.magee.edu    Principal Investigator: Hyagriv Simhan, MD, MS          United States, Rhode Island Brown University Recruiting Providence, Rhode Island, United States, 02905 Contact: Donna Allard, RNC    401-274-1122    dallard@wihri.org    Principal Investigator: Dwight J Rouse, MD          United States, Texas University of Texas Medical Branch Recruiting Galveston, Texas, United States, 77555 Contact: Ashley Salazar, MSN    409-772-0312    assalaza@utmb.edu    Principal Investigator: George R Saade, MD          University of Texas - Houston Recruiting Houston, Texas, United States, 77030 Contact: Felecia Ortiz, RN BSN    713-500-6467    Felecia.Ortiz@uth.tmc.edu    Principal Investigator: Suneet Chauhan, MD          United States, Utah University of Utah Medical Center Recruiting Salt Lake City, Utah, United States, 84132 Contact: Kim Hill, RN    801-585-7645    Kim.Hill@hsc.utah.edu    Principal Investigator: Michael W Varner, MD Less <<
NCT01428713 Menorrhagia Not Applicable Completed - United States, Texas ... More >> Baylor College of Medicine Houston, Texas, United States, 77030 Less <<
NCT02911233 - Completed - France ... More >> University Hospital Caen, Calvados, France, 14000 Less <<
NCT01428713 - Completed - -
NCT03710304 Cesarean Section Complications Not Applicable Recruiting June 1, 2020 Egypt ... More >> Aswan University Recruiting Aswan, Egypt, 81528 Contact: hany f sallam, md    01092440504 ext 002    nahla.elsayed@aswu.ed.eg Less <<
NCT02678208 Postpartum Hemorrhage Phase 2 Completed - Egypt ... More >> Assiut university Assiut, Egypt, 71111 Less <<
NCT00405093 - Completed - United States, New York ... More >> The New York Presbyterian Hospital - Weill Medical College of Cornell University New York, New York, United States, 10021 Less <<
NCT02616042 Labor Trial Refused Phase 3 Completed - -
NCT02352675 - Completed - United States, Massachusetts ... More >> Boston Children's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT00752024 Hypertensive Intracerebral Hem... More >>orrhage Less << Not Applicable Unknown December 2010 China, Hubei ... More >> Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology Not yet recruiting Wuhan, Hubei, China, 430030 Contact: wei wang, doctor    86-027-8366-3648    daodetongji@163.com    Contact: zhouping tang, doctor    86-013971616328    ddjtzp@163.com    Principal Investigator: wei wang, doctor Less <<
NCT01971684 - Completed - -
NCT00156520 Hemorrhage Phase 4 Completed - United States, New York ... More >> Strong Memorial Hospital, University of Rochester Rochester, New York, United States, 14642 Less <<
NCT00223704 Cardiopulmonary Bypass ... More >> Inflammation Fibrinolysis Surgery Less << Phase 2 Phase 3 Completed - United States, Tennessee ... More >> TN Valley Healthcare System Nashville, Tennessee, United States, 37212 Vanderbilt University Nashville, Tennessee, United States, 37232 Less <<
NCT01981863 Pathologic Fibrinolysis Phase 4 Completed - United States, California ... More >> Stanford Hospital & Clinics Stanford, California, United States, 94305 Less <<
NCT00617955 - Completed - United States, New York ... More >> SUNY Upstate Medical University Syracuse, New York, United States, 13210 Less <<
NCT00940745 Hypertensive Intracerebral Hem... More >>orrhage Less << Not Applicable Unknown March 2010 China, Hubei ... More >> Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology Not yet recruiting Wuhan, Hubei, China, 430030 Contact: wei wang, doctor    86-027-8366-3648    daodetongji@163.com    Contact: zhouping tang, doctor    86-013971616328    ddjtzp@163.com    Principal Investigator: wei wang, doctor Less <<
NCT01248104 Cardiopulmonary Bypass Not Applicable Unknown February 2015 United States, California ... More >> Loma Linda University Medical Center Loma Linda, California, United States, 92354 Less <<
NCT02238288 Oral Hemorrhage Phase 4 Unknown July 2015 Brazil ... More >> Clementino Fraga Filho University Hospital Rio de Janeiro, RJ, Brazil, 21864-440 Less <<
NCT01408823 - Completed - United States, Pennsylvania ... More >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00223704 - Completed - -
NCT00320619 Scoliosis Kyp... More >>hosis Lordosis Spondylitis Spinal Stenosis Less << Not Applicable Completed - United States, Maryland ... More >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 Less <<
NCT01981863 - Completed - -
NCT00958581 - Completed - -
NCT01527968 Osteoarthritis Not Applicable Unknown December 2016 -
NCT00958581 Scoliosis Phase 4 Completed - United States, New York ... More >> New York University School of Medicine - Department of Orthopaedic Surgery - Spine New York, New York, United States, 10016 Less <<
NCT01398280 Rosacea Early Phase 1 Completed - United States, California ... More >> University of California, San Diego Perlman Ambulatory Center La Jolla, California, United States, 92037 Less <<
NCT03365999 Knee Osteoarthritis ... More >> Blood Clot Transfusion Related Complication Blood Loss Less << Phase 2 Recruiting December 15, 2018 Mexico ... More >> Facultad de Medicina UANL Recruiting Monterrey, Nuevo Leon, Mexico, 1-4469 Contact: Felix Vilchez, MD, PHD       fvc78@hotmail.com    Contact: Rodolfo Morales-Avalos, MD    005218115557776    rodolfot59@hotmail.com Less <<
NCT02655653 Bleeding Not Applicable Completed - -
NCT00912119 Craniosynostosis Phase 1 Completed - United States, Pennsylvania ... More >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT02030821 - Completed - -
NCT02030821 Blood Loss Hi... More >>p Arthritis Knee Arthritis Less << Phase 4 Completed - United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27708 Less <<
NCT01391182 Degenerative Joint Disease ... More >> Osteoarthritis Less << Not Applicable Completed - United States, Florida ... More >> Mayo Clinic Jacksonville Jacksonville, Florida, United States, 32224 Less <<
NCT02639819 Intracerebral Hemorrhage Phase 1 Withdrawn(Study was withdrawn ... More >>from IRB review on 03/08/16) Less << December 2017 -
NCT02229968 Craniosynostosis Phase 2 Active, not recruiting December 2019 United States, District of Col... More >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 Less <<
NCT02074436 Hematological Malignancies ... More >> Thrombocytopenia Less << Phase 2 Recruiting May 2019 United States, Georgia ... More >> Emory University Hospital Recruiting Atlanta, Georgia, United States, 30322 Contact: Ana Antun, MD, MSc    404-593-6732    ana.antun@emoryhealthcare.org    Principal Investigator: Ana G. Antun, MD, MSc          Atlanta VA Medical Center Recruiting Decatur, Georgia, United States, 30033 Contact: Ana Antun, MD, MSc    404-593-6732    ana.antun@emoryhealthcare.org    Principal Investigator: Wayne B. Harris, MD Less <<
NCT02656472 Pediatric Cardiac Surgery ... More >> Complication of Extracorporeal Circulation Less << Phase 4 Completed - United States, Illinois ... More >> Advocate Childrens Hospital Oak Lawn, Illinois, United States, 60453 Less <<
NCT01873768 Osteoarthritis Phase 4 Completed - United States, Iowa ... More >> Miller Orthopedic Specialists Council Bluffs, Iowa, United States, 51503 Less <<
NCT01965730 Aortic Disease Early Phase 1 Terminated(the study was suspe... More >>nded due to shortage of the study drug (amicar).) Less << - United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT02257580 E-Aminocaproic Acid ... More >> Bilateral Varus Rotational Osteotomy Less << Phase 4 Recruiting January 2020 United States, New York ... More >> Hospital for Special Surgery Recruiting New York, New York, United States, 10021 Contact: David Scher, MD    212-606-1253    scherd@hss.edu    Contact: Emily Dodwell, MD MPH    212-606-1451    dodwelle@hss.edu    Sub-Investigator: Ishaan Swarup, MD Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.62mL

1.52mL

0.76mL

38.12mL

7.62mL

3.81mL

76.24mL

15.25mL

7.62mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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