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Chemical Structure| 6093-68-1 Chemical Structure| 6093-68-1
Chemical Structure| 6093-68-1

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6-Hydroxycoumarin is a derivative of coumarin with anti-inflammatory, antioxidant, and bronchodilator pharmacological activities. It has application value in drug development and therapeutic research.

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Product Details of 6-Hydroxycoumarin

CAS No. :6093-68-1
Formula : C9H6O3
M.W : 162.14
SMILES Code : O=C1C=CC2=C(O1)C=CC(O)=C2
MDL No. :MFCD00630040
InChI Key :CJIJXIFQYOPWTF-UHFFFAOYSA-N
Pubchem ID :99477

Safety of 6-Hydroxycoumarin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 6-Hydroxycoumarin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6093-68-1 ]

[ 6093-68-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6093-68-1 ]
  • [ 6608-47-5 ]
  • 2-oxo-2H-chromen-6-yl ethenesulfonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With triethylamine; In tetrahydrofuran; at 20℃; for 4h; General procedure: Coumarin sulfonates derivatives 4-43 were synthesized byreacting 3-hydroxy coumarin 1, 4-hydroxy coumarin 2 and 6-hydroxy coumarin 3 derivatives (1 mmol) with commercially available sulfonyl chlorides derivatives (1.2 mmol) in THF(15 mL) in the presence of triethyl amine (1 mmol). Reaction mixture was stirred for 4 h at room temperature to afford coumarin sulfonates 4-43. TLC monitoring was used to determine the progressof the reaction. After the completion of reaction, THF was evaporated and then solid product was washed with distilled water and dried under vacuum. The products were crystallized from methanol afforded good yields (Scheme 1).
 

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