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Chemical Structure| 55750-53-3 Chemical Structure| 55750-53-3
Chemical Structure| 55750-53-3

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Product Details of 6-Maleimidocapronic acid

CAS No. :55750-53-3
Formula : C10H13NO4
M.W : 211.21
SMILES Code : C1(N(C(C=C1)=O)CCCCCC(=O)O)=O
MDL No. :MFCD00043140
InChI Key :WOJKKJKETHYEAC-UHFFFAOYSA-N
Pubchem ID :573683

Safety of 6-Maleimidocapronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 6-Maleimidocapronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55750-53-3 ]

[ 55750-53-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 55750-53-3 ]
  • [ 474645-27-7 ]
  • [ 863971-24-8 ]
YieldReaction ConditionsOperation in experiment
36% With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 12h;Inert atmosphere; To a suspension of MMAE (0.05 g, 0.0694 mmol) in freshly distilled dry DCM (2 ml), 6-maleimidocaproic acid (0.0221 g, 0.104 mmol) was added followed by diethylcyanophosphonate (21 muIota, 0.139 mmol) and DIPEA (37 muIota, 0.208 mmol). On addition of DIPEA, the reaction mixture became clear and was stirred at room temperature under nitrogen for 12 h, TLC [silica gel: 5percent MeOH/DCM, Rf 0.31]. The reaction mixture was diluted with DCM (30 ml) and washed with 10percent citric acid (2 X 20 ml), water (20 ml), brine (20 ml) and concentrated to dryness. The crude was purified by flash column chromatography [silica gel: 5percent MeOH/DCM] to give 6- Maleimidocaproyl-MMAE 37 as a white solid 0.023 g (36percent). MS (m/z) found 911.58 (M+1) calculated for C49H79N6O10
 

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