Alternatived Products of [ 60-27-5 ]
Alternatived Products of [ 60-27-5 ]
Product Details of [ 60-27-5 ]
CAS No. : | 60-27-5 |
MDL No. : | MFCD00059730 |
Formula : |
C4H7N3O
|
Boiling Point : |
201.1±23.0°C at 760 mmHg |
Linear Structure Formula : | - |
InChI Key : | N/A |
M.W : | 113.12 g/mol |
Pubchem ID : | 588 |
Synonyms : |
|
Safety of [ 60-27-5 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
Hazard Statements: | H302 |
Packing Group: | N/A |
GHS Pictogram: |
|
Application In Synthesis of [ 60-27-5 ]
- Upstream synthesis route of [ 60-27-5 ]
- Downstream synthetic route of [ 60-27-5 ]
- 1
-
[ 13200-60-7 ]

-
[ 420-04-2 ]

-
[ 60-27-5 ]
- 2
-
<i>N</i>-carbamimidoyl-<i>N</i>-methyl-glycine methyl ester
[ No CAS ]

-
[ 623-11-0 ]

-
[ 60-27-5 ]
- 3
-
[ 621-59-0 ]

-
[ 60-27-5 ]

-
[ 106-38-7 ]

-
3-(4-Hydroxy-3-p-tolyloxy-phenyl)-2-methylamino-propionic acid
[ No CAS ]
- 4
-
[ 622-42-4 ]

-
[ 60-27-5 ]

-
[ 89114-29-4 ]
- 5
-
[ 29559-27-1 ]

-
[ 60-27-5 ]

-
[ 89114-30-7 ]
- 6
-
[ 60-27-5 ]

-
[ 79-24-3 ]

-
[ 89114-32-9 ]
- 7
-
[ 60-27-5 ]

-
[ 29559-24-8 ]

-
[ 89114-31-8 ]
- 8
-
[ 60-27-5 ]

-
[ 88-89-1 ]

-
C10H8N6O8(2-)*2Na(1+)
[ No CAS ]
- 9
-
[ 60-27-5 ]

-
[ 132303-53-8 ]

-
[ 132303-57-2 ]
- 10
-
[ 60-27-5 ]

-
[ 132303-54-9 ]

-
[ 132303-59-4 ]
- 11
-
[ 60-27-5 ]

-
[ 132303-55-0 ]

-
[ 132303-61-8 ]
- 12
-
[ 60-27-5 ]

-
4-(2-methoxy-5-methylphenoxy)-benzaldehyde
[ No CAS ]

-
3-[4-(2-Hydroxy-5-methyl-phenoxy)-phenyl]-2-methylamino-propionic acid
[ No CAS ]
- 13
-
[ 60-27-5 ]

-
[ 108-03-2 ]

-
[ 89114-33-0 ]
- 14
-
[ 60-27-5 ]

-
[ 97073-61-5 ]

-
[ 97073-69-3 ]
- 15
-
[ 60-27-5 ]

-
[ 97073-60-4 ]

-
[ 97073-66-0 ]
- 16
-
[ 60-27-5 ]

-
[ 97073-62-6 ]

-
[ 97073-72-8 ]
- 17
-
[ 60-27-5 ]

-
[ 99053-84-6 ]

-
[ 99053-88-0 ]
- 18
-
[ 60-27-5 ]

-
[ 99053-86-8 ]

-
[ 99053-92-6 ]
- 19
-
[ 60-27-5 ]

-
[ 99053-85-7 ]

-
[ 99053-90-4 ]
- 20
-
5-(2-chloro-5-(trifluoromethyl)phenyl)furan-2-carbaldehyde
[ No CAS ]

-
[ 60-27-5 ]

-
BI-11B11
[ No CAS ]
- 21
-
[ 60-27-5 ]

-
[ 34035-03-5 ]

-
[ 541-41-3 ]

-
BI-11C11
[ No CAS ]
- 22
-
[ 60-27-5 ]

-
[ 34035-03-5 ]

-
5-[5-(4-chlorophenyl)furan-2-ylmethylene]-2-imino-1-methyl-imidazolidin-4-one
[ No CAS ]
- 23
-
[ 60-27-5 ]

-
[ 74-88-4 ]

-
[ 56107-25-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
In ethyl acetate; N,N-dimethyl-formamide; |
REFERENCE EXAMPLE a-3 Preparation of 2-imino-1,3-dimethylimidazol-4-ine hydrochloride STR733 16.9 g (150 mmol) of <strong>[60-27-5]creatinine</strong> was dissolved in 100 ml of N,N-dimethylformamide. Then, 27.6 g (194 mmol) of methyl iodide was added thereto, and the mixture was heated to 50 C. and stirred at that temperature for 2 hours and further at room temperature overnight. To the reaction mixture, 500 ml of ethyl acetate was added, and crystals were collected by filtration. The obtained crystals were washed with ethyl acetate and dried to obtain 26.2 g of 2-imino-1,3-dimethylimidazolidin-4-one hydroiodide as white crystals. |
- 24
-
[ 60-27-5 ]

-
[ 107-08-4 ]

-
1-methyl-3-n-propyl-2-iminoimidazolidin-4-one
[ No CAS ]

-
1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
In N-methyl-acetamide; ethyl acetate; |
REFERENCE EXAMPLE d-2 Preparation of 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide STR745 9.04 g (80 mmol) of <strong>[60-27-5]creatinine</strong> was suspended in 50 ml of dimethylformamide, and 17.0 g (100 mmol) of n-propyl iodide was added thereto. Then, the mixture was heated and stirred within a range of from 70 C. to 80 C. until <strong>[60-27-5]creatinine</strong> was completely dissolved. The mixture was left to cool, and 500 ml of ethyl acetate was added thereto. Precipitated crystals were collected by filtration to obtain 10.6 g of 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide. Melting point: 159-161 C. The 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide was neutralized in accordance with the following method to obtain 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one. |
- 25
-
[ 60-27-5 ]

-
[ 2124-55-2 ]

-
N-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-1H-indole-4-carboxamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 - 30℃;Inert atmosphere; |
General procedure: Compounds (4a-u) synthesized from N-substituted-4-indole carboxylic acids (3a-o) and derivatives (4p-u) from heterocyclic carboxylic acids using standard amidation reaction. To a 100 ml single neck RB flask, (N-substituted-4-indole carboxylic acids (3a-u)) (1 eq/1mol), creatinine (1.5 eq/1.5 mol), HATU (1 eq/1 mol) and DMF(8-12 V) were added under nitrogen atmosphere and stirred for 5mins at 20-30 C. Upon a clear solution formed, DIPEA (2 eq or 2 mol) was added and the reaction mass stirred again for 12-16 h at 20-30 C. After 12-16 h, TLC/LCMS confirmed the completion of the reaction. Ice-cold water (20 volumes) was added slowly to the reaction mixture under stirring condition. The product was extracted with dichloromethane(2×10 volumes). The combined dichloromethane extract washed with(10 volumes) water and the organic layer separated then dried over anhydrous sodium sulfate. Further, the volatiles was distilled off under reduced pressure to get the crude product. The crude material further purified using column chromatography with silica as the stationary phase and MDC: MeOH as the mobile phase to get pure products (4a-u) with 60-88% yield. |