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[ CAS No. 60468-36-2 ] {[proInfo.proName]}

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Product Details of [ 60468-36-2 ]

CAS No. :60468-36-2 MDL No. :MFCD04115827
Formula : C8H5ClF2O Boiling Point : -
Linear Structure Formula :- InChI Key :HJWDDTDVBUFTCP-UHFFFAOYSA-N
M.W : 190.57 Pubchem ID :4989978
Synonyms :

Safety of [ 60468-36-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 60468-36-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 60468-36-2 ]
  • Downstream synthetic route of [ 60468-36-2 ]

[ 60468-36-2 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 540-36-3 ]
  • [ 79-04-9 ]
  • [ 60468-36-2 ]
YieldReaction ConditionsOperation in experiment
84% at 0 - 60℃; for 2 h; To a suspension of AlC (34.59 g, 259 mmol) in 1 ,4-difluorobenzene (20 g, 18.18 ml_, 175.3 mmol) at 0°C, chloroacetyl chloride (21.778 g, 192.83 mmol) is added dropwise within 20 min. under stirring. After 1 h at 0 °C, the reaction mixture is heated at 60°C for an extra hour during which time a clear solution is formed. The solution is poured into ca. 400 ml_ of ice cooled 1 M HCI. The colourless solid which precipitates and the solution is extracted with Et2O (3x50 ml_) and the organic phase washed with saturated NaHCO3 (40 ml_), dried (MgSO4) and concentrated at the rotoevaporator to furnish 27.93 g (84percent yield) of colourless crystals.
Reference: [1] Patent: WO2015/139859, 2015, A1, . Location in patent: Paragraph 0079
[2] Organic Letters, 2007, vol. 9, # 4, p. 667 - 669
[3] Pharmazie, 1976, vol. 31, # 6, p. 351 - 354
[4] Tetrahedron Asymmetry, 2007, vol. 18, # 8, p. 949 - 962
  • 2
  • [ 60468-36-2 ]
  • [ 241479-67-4 ]
Reference: [1] Patent: CN106317044, 2017, A,
  • 3
  • [ 60468-36-2 ]
  • [ 241479-74-3 ]
Reference: [1] Patent: CN105777740, 2016, A,
[2] Patent: CN106317044, 2017, A,
  • 4
  • [ 288-36-8 ]
  • [ 60468-36-2 ]
  • [ 1157938-97-0 ]
YieldReaction ConditionsOperation in experiment
73% With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 10 h; A) to the reactor were added successively 1mol difluorophenyl chloride, 1.2mol triazole, 0.15molCuI, 1.5mol potassium carbonate and 0.8LDMF (N, N- dimethylformamide), heated to 80 stirred 10 hours, TLC (thin layer chromatography) to detect the reaction was complete; the filtrate was filtered, concentrated under reduced pressure recovery DMF, the residue is recrystallized from ethyl acetate-white solid, that is the first product in a yield of 73percent ;
Reference: [1] Patent: CN105777740, 2016, A, . Location in patent: Paragraph 0019; 0023
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