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CAS No. : | 60933-65-5 | MDL No. : | MFCD00151460 |
Formula : | C7H9NOS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 155.22 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P264-P270-P301+P312-P330-P501 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 135℃; for 3h; microwave irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | Stage #1: 2,6-dichlorobenzoic acid methyl ester; (R)-S-methyl-S-phenylsulfoximine With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 20℃; for 0.5h; Stage #2: In toluene at 135℃; for 1.5h; microwave irradiation; Further stages.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; at 110℃; | Intermediate 10: Preparation of 4-chloro-6-[methyl(oxido)phenyl-lambda4- sulphanylidene]amino}quinoline960 mg (6.19 mmol) of R-(-)-S-methyl-S-phenylsulphoximine, 142 mg (0.16 mmol) of tris(dibenzylideneacetone)dipalladium, 215 mg (0.37 mmol) of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene and 543 mg (7.42 mmol) of sodium tert-butoxide are added to 1.5 g (6.19 mmol) of 6-bromo-4- chloroquinoline in 64 ml of 1,4-dioxane under argon. After stirring at 1100C overnight, the mixture is cooled and filtered through Celite. The solvent is removed from the filtrate under reduced pressure, and the residue is purified by chromatography on a silica gel column (mobile phase: dichloromethane: methanol 100:1 ). 1.43 g (73%) of the title compound are obtained.1H-NMR (500 MHz, D6-DMSO): delta = 3.52 (s, 3H), 7.4-7.46 (m, 2H), 7.53-7.7 (m, 4H), 7.86 (d, 1H), 8.0 (d, 2H), 8.56 (d, 1 H). MS (ESpos): 317.1 [M+H] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 135℃; for 36h; |