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Chemical Structure| 6106-04-3 Chemical Structure| 6106-04-3
Chemical Structure| 6106-04-3

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H-Glu-OH(Sodium)·H₂O is a nutritional additive and flavoring agent that can reduce obesity and induce metabolic disorders associated with oxidative stress, while also causing oxidative stress, DNA damage, and apoptosis in mouse liver and brain tissues.

Synonyms: L-Glutamic acid monosodium(hydrate)

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Product Citations

Product Citations

White, Amelia M ; Mitchell, Aaron P ;

Abstract: Candida albicans, a fungal commensal and pathogen, occupies diverse niches in the human host. Its broad metabolic repertoire is critical for its survival. The model yeast Saccharomyces cerevisiae provides a starting point for analysis of C. albicans physiology and regulatory circuitry, but there are many examples of rewired transcription factors that govern different processes in the two organisms. We focus here on Adr1, which in S. cerevisiae promotes alternative carbon source utilization and in C. albicans promotes ergosterol synthesis. We find that C. albicans Adr1 is also required for growth on citrate and compounds that feed into the citric acid cycle, like glutamate and malate. RNA-sequencing (RNA-seq) shows that predicted citrate metabolic genes, representing both the citric acid cycle and gluconeogenesis, are downregulated in an adr1Δ/Δ mutant. In fact, the three Adr1-dependent genes HGT17, MDH1, and PCK1 are required for growth on citrate, as indicated by deletion mutant phenotypes. The hyphal regulator EED1 has a negative role in citrate utilization, and an adr1Δ/Δ eed1Δ/Δ double mutant is defective for growth on citrate. This result argues that Adr1 acts downstream or independently of Eed1 to govern citrate utilization. C. albicans Adr1 is rewired compared to its S. cerevisiae ortholog to govern the ability to use citrate, which S. cerevisiae lacks, and potentially to respond to Eed1, for which S. cerevisiae lacks an ortholog.

Keywords: Candida albicans ; carbon metabolism ; transcriptional regulation ; regulatory rewiring

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Product Details of Sodium L-Glutamate Monohydrate

CAS No. :6106-04-3
Formula : C5H11NNaO5
M.W : 188.13
SMILES Code : O=C([C@H](CCC(O)=O)N)O.[H]O[H].[Na]
Synonyms :
L-Glutamic acid monosodium(hydrate)
MDL No. :MFCD00150138

Safety of Sodium L-Glutamate Monohydrate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
 

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