Alternatived Products of [ 61070-20-0 ]
Product Details of [ 61070-20-0 ]
CAS No. : | 61070-20-0 |
MDL No. : | MFCD00076944 |
Formula : |
C12H19N3O4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
269.30
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 61070-20-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 61070-20-0 ]
- 1
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[ 99464-83-2 ]
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[ 61070-20-0 ]
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Nα-tert-butoxycarbonyl-Nϖ-methyl-L-histidine 1-(cyclohexyloxycarbonyloxy)ethyl ester
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
53% |
|
Example 47 Production of Nalpha-tert-butoxycarbonyl-N?-methyl-L-histidine 1-(cyclohexyloxycarbonyloxy)ethyl ester Into a suspension of potassium carbonate (2.1 g, 14.9 mmol) in DMF (20 mL) was dropped a solution of Nalpha-tert-butoxycarbonyl-N?-methyl-L-histidine (2.0 g, 7.4 mmol) in DMF (20 mL) at 0 C. followed by stirring at room temperature for 0.5 hour. 1-Chloroethylcyclohexyl carbonate (1.8 g, 8.9 mmol) was dropped into the above mixture at 0 C. followed by stirring at room temperature for 20 hours. The reaction solution was poured over ice water, the mixture was extracted with ethyl acetate and the organic layer was dried over anhydrous sodium sulfate. The residue prepared by evaporation of the solvent therefrom in vacuo was purified by silica gel column chromatography (chloroform methanol=30:1) to give the title compound (1.7 g, 53%) as an oily substance. MS (EI) m/z: 440 (M+). 1H-NMR (DMSO-d6) delta: 1.32-1.44 (m, 15H), 1.62-1.64 (m, 2H), 1.81-1.83 (m, 2H), 2.89-2.94 (m, 2H), 3.31 (s, 3H), 3.52-3.53 (m, 3H), 4.21-4.23 (m, 1H), 4.54-4.56 (m, 1H), 6.62-6.66 (m, 2H), 7.39-7.41 (m, 1H), 7.48-7.49 (m, 1H). |