Alternatived Products of [ 61830-40-8 ]
Product Details of [ 61830-40-8 ]
CAS No. : 61830-40-8
MDL No. : MFCD06411110
Formula :
C6 H3 Br2 NO2
Boiling Point :
-
Linear Structure Formula : -
InChI Key : BXFONYCBYSYAJE-UHFFFAOYSA-N
M.W :
280.90
Pubchem ID : 12361242
Synonyms :
Calculated chemistry of [ 61830-40-8 ]
Physicochemical Properties
Num. heavy atoms :
11
Num. arom. heavy atoms :
6
Fraction Csp3 :
0.0
Num. rotatable bonds :
1
Num. H-bond acceptors :
3.0
Num. H-bond donors :
1.0
Molar Refractivity :
46.6
TPSA :
50.19 Ų
Pharmacokinetics
GI absorption :
High
BBB permeant :
Yes
P-gp substrate :
No
CYP1A2 inhibitor :
No
CYP2C19 inhibitor :
No
CYP2C9 inhibitor :
No
CYP2D6 inhibitor :
No
CYP3A4 inhibitor :
No
Log Kp (skin permeation) :
-6.53 cm/s
Lipophilicity
Log Po/w (iLOGP) :
1.9
Log Po/w (XLOGP3) :
2.09
Log Po/w (WLOGP) :
2.3
Log Po/w (MLOGP) :
0.41
Log Po/w (SILICOS-IT) :
2.12
Consensus Log Po/w :
1.76
Druglikeness
Lipinski :
0.0
Ghose :
None
Veber :
0.0
Egan :
0.0
Muegge :
0.0
Bioavailability Score :
0.56
Water Solubility
Log S (ESOL) :
-3.24
Solubility :
0.163 mg/ml ; 0.000581 mol/l
Class :
Soluble
Log S (Ali) :
-2.77
Solubility :
0.473 mg/ml ; 0.00168 mol/l
Class :
Soluble
Log S (SILICOS-IT) :
-3.1
Solubility :
0.223 mg/ml ; 0.000794 mol/l
Class :
Soluble
Medicinal Chemistry
PAINS :
0.0 alert
Brenk :
0.0 alert
Leadlikeness :
0.0
Synthetic accessibility :
1.63
Application In Synthesis of [ 61830-40-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Upstream synthesis route of [ 61830-40-8 ]
Downstream synthetic route of [ 61830-40-8 ]
1
[ 61830-40-8 ]
3,5-dibromo-pyridine-2-carbonyl chloride
[ No CAS ]
2
[ 698393-07-6 ]
[ 61830-40-8 ]
4
[ 61830-40-8 ]
[ 61830-41-9 ]
5
[ 61830-40-8 ]
3,5-dibromo-pyridine-2-carboxylic acid amide
[ No CAS ]
6
[ 61830-40-8 ]
3,5-dibromo-pyridine-2-carboxylic acid phenyl ester
[ No CAS ]
7
[ 858852-20-7 ]
[ 61830-40-8 ]
8
[ 861019-41-2 ]
[ 61830-40-8 ]
9
[ 61830-09-9 ]
[ 61830-40-8 ]
Yield Reaction Conditions Operation in experiment
With sulfuric acid; acetic acid; In hexane; water;
(3) 2-Cyano-3,5-dibromopyridine (prepared in the above (2)) 3.27 g is added to a mixture of acetic acid 14 ml, sulfuric acid 14 ml and water 14 ml, and the mixture is refluxed at 140 C. for 4 hours. The reaction mixture is cooled and water is added thereto. The resulting precipitate is filtered and washed with water. The precipitate is dissolved in ether, washed and dried. The solvent is removed in vacuo and crystallized from a mixture of ether and hexane to give 3,5-dibromopyridine-2-carboxylic acid. mp 170-171 C.
10
[ 61830-40-8 ]
methyl 5-bromo-3-formyl-2-picolinate
[ No CAS ]
11
[ 61830-40-8 ]
methyl 5-bromo-3-(difluoromethyl)picolinate
[ No CAS ]
12
[ 61830-40-8 ]
methyl 5-cyano-3-(difluoromethyl)picolinate
[ No CAS ]
13
[ 61830-40-8 ]
5-cyano-3-(difluoromethyl)picolinic acid
[ No CAS ]
14
[ 61830-40-8 ]
[ 68-12-2 ]
5-bromo-3-formylpicolinic acid
[ No CAS ]
Yield Reaction Conditions Operation in experiment
To n-butyllithium (2.5 M in hexane, 12 mL, 30 mmol) in THF (40 mL) at -78 C was added a solution of <strong>[61830-40-8]3,5-dibromopicolinic acid</strong> (4.0 g, 14 mmol) in THF (60 mL) over 30 minutes. The reaction was stirred at -78 C for 1 hour after which DMF (11 mL, 144 mmol) was added dropwise. The cold bath was allowed to expire while stirring for 12 h. Water was added followed by IN HC1 (30 mL). The pH was adjusted to pH 3-4 using IN NaOH. The solution was extracted with EtOAc while maintaining a pH of 3 to 4. The combined organic layerswere washed with water and brine, dried (MgS04), filtered, and concentrated in vacuo to provide the title compound Ab2 that was carried on directly.
15
[ 61830-40-8 ]
3-ethyl-5-[2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl]-pyridine-2-carboxylic acid
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 20 - 50 °C / Inert atmosphere
7: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 50 °C / Inert atmosphere
7: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
16
[ 61830-40-8 ]
3-ethyl-5-[2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl]pyridine-2-carboxylic acid
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 16 h / 50 °C
7: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 16 h / 50 °C
7: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C
17
[ 61830-40-8 ]
3-ethyl-5-[2-(5-methoxyquinoline-8-sulfonylamino)phenylethynyl]pyridine-2-carboxylic acid
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 90 °C / Sealed tube; Inert atmosphere
7: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
Multi-step reaction with 7 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 90 °C / Inert atmosphere; Sealed tube
7: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
18
[ 61830-40-8 ]
methyl 3-bromo-5-[2-(trimethylsilyl)ethynyl]pyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 2 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
Multi-step reaction with 2 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
19
[ 61830-40-8 ]
methyl 3-ethyl-5-[2-(trimethylsilyl)ethynyl]pyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 3 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
Multi-step reaction with 3 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
20
[ 61830-40-8 ]
methyl 3-ethyl-5-ethynylpyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
Multi-step reaction with 4 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
21
[ 61830-40-8 ]
methyl 5-[2-(2-aminophenyl)ethynyl]-3-ethylpyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
Multi-step reaction with 5 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
22
[ 61830-40-8 ]
methyl 3-ethyl-5-[2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl]pyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 20 - 50 °C / Inert atmosphere
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 50 °C / Inert atmosphere
23
[ 61830-40-8 ]
methyl 3-ethyl-5-[2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl]pyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 16 h / 50 °C
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 16 h / 50 °C
24
[ 61830-40-8 ]
methyl 3-ethyl-5-[2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl]pyridine-2-carboxylate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.5 h / 20 - 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 90 °C / Sealed tube; Inert atmosphere
Multi-step reaction with 6 steps
1: thionyl chloride / 70 °C / Inert atmosphere
2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4: potassium fluoride / methanol / 2 h / 20 °C / Inert atmosphere
5: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 80 °C / Inert atmosphere
6: pyridine; dmap / 3 h / 90 °C / Inert atmosphere; Sealed tube
25
[ 67-56-1 ]
[ 61830-40-8 ]
[ 61830-41-9 ]
Yield Reaction Conditions Operation in experiment
90%
With thionyl chloride at 70℃; Inert atmosphere;
6 Synthesis of 3-ethyl-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}- pyridine-2-carboxylic acid
To a stirred solution of 3,5-dibromopyridine-2-carboxylic acid (5 g, 16.91 mol, 1 eq) in MeOH (20 ml_) was added SOCI2 (3.2 g, 25.55 mmol, 1.51 eq) at room temperature. The resulting mixture was stirred overnight at 70°C under nitrogen atmosphere. The resulting solution was diluted with 50 ml_ of H20. The resulting solution was extracted with 3x50 ml_ of ethyl acetate and the organic layers combined. The mixture was dried over anhydrous sodium sulfate. The remainder after filtration was concentrated under vacuum. This resulted in methyl 3,5-dibromopyridine-2-carboxylate (5 g, 90%) as a white
90%
With thionyl chloride at 70℃; Inert atmosphere;
6
To a stirred solution of 3,5-dibromopyridine-2-carboxylic acid (5 g, 16.91 mol, 1 eq) in MeOH (20 mL) was added SOCI2 (3.2 g, 25.55 mmol, 1.51 eq) at room temperature. The resulting mixture was stirred overnight at 70°C under nitrogen atmosphere. The resulting solution was diluted with 50 mL of H2O . The resulting solution was extracted with 3x50 mL of ethyl acetate and the organic layers combined. The mixture was dried over anhydrous sodium sulfate. The remainder after filtration was concentrated under vacuum. This resulted in methyl 3,5-dibromopyridine-2-carboxylate (5 g, 90%) as a white solid.
90%
With thionyl chloride at 70℃; Inert atmosphere;
6
To a stirred solution of 3,5-dibromopyridine-2-carboxylic acid (5 g, 16.91 mol, 1 eq) in MeOH (20 mL) was added SOCI2 (3.2 g, 25.55 mmol, 1.51 eq) at room temperature. The resulting mixture was stirred overnight at 70°C under nitrogen atmosphere. The resulting solution was diluted with 50 mL of H2O . The resulting solution was extracted with 3x50 mL of ethyl acetate and the organic layers combined. The mixture was dried over anhydrous sodium sulfate. The remainder after filtration was concentrated under vacuum. This resulted in methyl 3,5-dibromopyridine-2-carboxylate (5 g, 90%) as a white solid.
26
[ 61830-40-8 ]
5-bromo-3-formylpicolinic acid
[ No CAS ]
Yield Reaction Conditions Operation in experiment
3.37 g
With n-butyllithium In tetrahydrofuran; N,N-dimethyl-formamide at -70 - 0℃; for 3h;
64.1
To a solution of n-BuLi (2.5 M, 15.66 mL) in THF (50 mL) was added 3,5- dibromopicolinic acid (5 g, 17.80 mmol) in THF (75 mL) at -70 °C. After 1 hr, DMF (13.01 g, 178.00 mmol) was added to the mixture and stirring was continued at 0 °C for 2 hrs. The reaction mixture was quenched by addition of H2O (100 mL) at 20 °C and extracted with EtOAc (90 mL x 5). The aqueous phase was acidified with 1N HCl to pH=3 and extracted with EtOAc (90 mL x 3). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound (3.37 g) as a yellow oil which was used without further purification.
27
[ 61830-40-8 ]
methyl 5-bromo-3-(dimethoxymethyl)picolinate
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 2 steps
1: n-butyllithium / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / -70 - 0 °C
2: sulfuric acid / 1 h / 70 °C
28
[ 61830-40-8 ]
(x)C2 HF3 O2 *C19 H11 F2 N5 O2
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / -70 - 0 °C
2.1: sulfuric acid / 1 h / 70 °C
3.1: toluene-4-sulfonic acid / water; 1,4-dioxane / 16 h / 50 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 12 h / 20 °C
5.1: potassium trimethylsilonate / tetrahydrofuran / 0.17 h / 20 °C
6.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 2.5 h / 20 °C
6.2: Welch Ultimate AQ-C18 150 x 30mm x 5μm