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Chemical Structure| 61850-95-1 Chemical Structure| 61850-95-1

Structure of 61850-95-1

Chemical Structure| 61850-95-1

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Product Details of [ 61850-95-1 ]

CAS No. :61850-95-1
Formula : C10H13BrO
M.W : 229.11
SMILES Code : CCOC1=CC=CC=C1CCBr

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Application In Synthesis of [ 61850-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61850-95-1 ]

[ 61850-95-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7768-28-7 ]
  • [ 22545-14-8 ]
  • [ 75-03-6 ]
  • [ 124-63-0 ]
  • [ 61850-95-1 ]
YieldReaction ConditionsOperation in experiment
With lithium bromide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone; Step A: Preparation of ethoxyphenethyl bromide STR30 To a suspension of 1.00 g (7.24 mmol) of 2-hydroxyphenethyl alcohol and 1.35 g (8.68 mmol) of potassium carbonate in 15 ml of N,N-dimethylformamide was added 2.00 g (14.48 mmol) of iodoethane at 0° C. The reaction mixture was stirred at 40-45° C. for 12 h and was poured into 200 ml of ether. It was washed with water (20 ml *3), dried over MgSO4 and concentrated. The residue was purified by silica gel chromatography with 9:1 hexane/ethyl acetate to afford the 2-ethoxyphenethyl alcohol as a colorless oil. To a solution of 1.35 g (8.12 mmol) of 2-ethoxyphenethyl alcohol and 2.05 g (20.03 mmol) of triethylamine in 15 ml of dichloromethane was slowly added 1.86 g (16.24 mmol) of methanesulfonyl chloride at 0° C. The reaction mixture was stirred at 0° C. for 2 h and was poured into 200 ml of mixed solution of hexanelether(1:1). It was washed with 30 ml of water, dried over MgSO4, filtered through a plug of silica gel and concentrated. The residue was dissolved in 30 ml of acetone and 2.82 g (32.48 mmol) of lithium bromide was added slowly at 0° C. The reaction mixture was refluxed for 5 h and volatiles were removed. The residue was added 150 ml of ether, washed with water (30 ml *2), dried over MgSO4, filtered through a plug of silica gel and concentrated to give 2-ethoxyphenethyl bromide as a colorless oil.
 

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