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[ CAS No. 625-56-9 ] {[proInfo.proName]}

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Chemical Structure| 625-56-9
Chemical Structure| 625-56-9
Structure of 625-56-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 625-56-9 ]

CAS No. :625-56-9 MDL No. :MFCD00623643
Formula : C3H5ClO2 Boiling Point : -
Linear Structure Formula :- InChI Key :SMJYMSAPPGLBAR-UHFFFAOYSA-N
M.W : 108.52 Pubchem ID :69366
Synonyms :

Safety of [ 625-56-9 ]

Signal Word:Danger Class:3,8
Precautionary Statements:P261-P280-P305+P351+P338-P310 UN#:2924
Hazard Statements:H225-H314-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 625-56-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 625-56-9 ]

[ 625-56-9 ] Synthesis Path-Downstream   1~85

  • 1
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  • 1-acetoxymethyl-quinolinium; chloride [ No CAS ]
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  • [ 127-08-2 ]
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  • [ 16199-06-7 ]
  • acetic acid pyrrol-1-ylmethyl ester [ No CAS ]
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  • [ 139-02-6 ]
  • [ 122-79-2 ]
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  • [ 865-48-5 ]
  • acetic acid <i>tert</i>-butoxymethyl ester [ No CAS ]
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  • [ 54-21-7 ]
  • [ 6318-65-6 ]
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  • [ 60-35-5 ]
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  • [ 121-44-8 ]
  • acetoxymethyl-triethyl-ammonium; chloride [ No CAS ]
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  • [ 62-53-3 ]
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  • [ 29921-57-1 ]
  • β-Acetoxypropionsaeure-isopropylester [ No CAS ]
  • 36
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  • [ 35223-80-4 ]
  • 3-acetoxy-propionic acid propyl ester [ No CAS ]
  • 37
  • [ 625-56-9 ]
  • [ 59956-48-8 ]
  • isobutyl 3-acetoxypropionate [ No CAS ]
  • 39
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  • [ 530-78-9 ]
  • [ 29098-19-9 ]
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  • [ 644-62-2 ]
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  • [ 1798-09-0 ]
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  • [ 52034-03-4 ]
  • β-Acetoxypropionsaeure-pentylester [ No CAS ]
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  • [ 38540-80-6 ]
  • 17β-Acetoxymethoxycarbonyl-3α-hydroxy-5α-androstan-11-one [ No CAS ]
  • 46
  • [ 625-56-9 ]
  • dimethyl-phenoxymethylene-ammonium bromide [ No CAS ]
  • Sodium; 6-methyl-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16R)-3,11,16-trihydroxy-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-hept-5-enoate [ No CAS ]
  • 2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16R)-16-Bromo-3-formyloxy-11-hydroxy-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-6-methyl-hept-5-enoic acid acetoxymethyl ester [ No CAS ]
  • 47
  • [ 625-56-9 ]
  • Sodium; 2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-3,11-dihydroxy-16-isopropylsulfanyl-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-6-methyl-hept-5-enoate [ No CAS ]
  • [ 62705-51-5 ]
  • 48
  • [ 625-56-9 ]
  • Sodium; 2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-3,11-dihydroxy-4,8,10,14-tetramethyl-16-(propane-2-sulfinyl)-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-6-methyl-hept-5-enoate [ No CAS ]
  • 2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-3,11-Dihydroxy-4,8,10,14-tetramethyl-16-(propane-2-sulfinyl)-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-6-methyl-hept-5-enoic acid acetoxymethyl ester [ No CAS ]
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  • [ 50-00-0 ]
  • [ 75-36-5 ]
  • [ 625-56-9 ]
YieldReaction ConditionsOperation in experiment
45% With zinc(II) chloride; at 0 - 90℃; for 16h; To a mixture of paraformaldehyde (1 .913 g, 63.7 mmol) and zinc chloride (0.174 g, 1.274 mmol) was added acetyl chloride (5 g, 63.7 mmol) dropwise at 0 C. The reaction mixture was allowed to warm to 27 C and stirred at 90 C for 16 hr. Then, the reaction mixture was quenched with saturated NaHC03 (20 ml_) and extracted with Et20 (2 c 50 ml_). The combined organic layers were washed with brine solution (50 ml_), dried over Na2S04, filtered and concentrated under reduced pressure to afford the crude residue (4.2 g). The crude compound was purified by fractional distillation at 120 C to afford pure chloromethyl acetate (1 .5 g, Yield: 45%, colourless liquid). 1H NMR (400 MHz, CDCI3) d = 5.69 (s, 2H), 2.15 (s, 3H).
29% zinc(II) chloride; at 75 - 80℃; for 3h; Chloromethyl acetate was prepared according to the method OF NUDELMAN ET AL., 2001 : A mixture of acetyl chloride (5. 00 g, 64 MMOL), PARAFORMALDEHYDE (1. 91g, 64 mmol) and ZNCL2 (CAT.) were mixed together at room temperature. An exothermic reaction occurred after several minutes, whereupon the temperature reached 75-80 C. After the exotherm was completed, the reaction was heated to 75 C FOR 3 HRS. The product was isolated by distillation (90-90. 5C, 760 MMHG) to give the product as A colorless oil (1. 96 g, 29 %).
15.3% With zinc(II) chloride; at 20 - 60℃; for 16.67h; Step 1) chloromethyl acetate To a mixture of acteyl chloride (10 mL, 94.6 mmol) and ZnCl2 (25 mg, 186 mmol) was added paraformaldehyde (2.84 g, 94.6 mmol). The reaction was stirred at rt for 40 min. It was then heated to 60 C. and stirred further for 16 h. The mixture was cooled to rt and filtered through a short silica gel column (100% PE). The solution was concentrate in vacuo at 30 C. and the resulting oil was distilled at 60 C. under reduced pressure to give the title compound as colorless oil (2.34 g, 15.3%). The title compound was characterized by 1H NMR as shown below: 1H NMR (400 MHz, CDCl3) delta 1.18-1.23 (d, J=7.0 Hz, 6H), 2.56-2.68 (m, 1H), 5.72 (s, 2H).
15.3% With zinc(II) chloride; at 20 - 60℃; for 16.66h; To acetyl chloride (10 mL, 94.6 mmol)And zinc chloride (25mg, 186mmol)Added to the mixture Paraformaldehyde(2.84 g, 94.6 mmol).After the reaction solution was stirred at room temperature for 40 minutes,Rise to 60 C,Stirring was continued for 16 hours.After the reaction,After cooling to room temperature, the mixture was filtered through a short silica gel column (100% PE).The filtrate was concentrated under reduced pressure at 30 C.The resulting residue was distilled under reduced pressure at 60 C.The title compound was obtained as a colorless oil (2.34 g, 15.3%).
With zinc(II) chloride; at 60℃; for 0.5h; A mixture of 7.85 g (100 mmole) of acetyl chloride, 3 g (100 mmole) of paraformaldehyde and 10 mg of anhydrous zinc chloride is heated to 60 C. for about 30 minutes and paraformaldehyde is dissolved. The mixture is distilled under reduced pressure (25 mm Hg) and the distillate (b.p. 40-42/25 mm) is collected by cooling with dry ice. The product, 8.3 g of chloromethyl acetate, is obtained.
With zinc(II) chloride; at -10 - 20℃;Inert atmosphere; 7.B) Synthesis of 1-chloromethyl Acyl Ester Derivatives To a flask charged with a catalytic amount of ZnCl2 under N2 was added an acyl chloride (e.g., propionyl chloride) (1 equiv), and the mixture was cooled to -5 to -10 C. Paraformaldehyde (1.38 g, 46 mmol) was then added dropwise, and the resulting reaction mixture was stirred at rt for 1 h. The mixture was concentrated under the reduced pressure to afford the crude product. The crude product (e.g., chloromethyl propionate) was used directly in next step without any further purification.7.6.1 Synthesis of chloromethyl acetate The title compound was synthesized from acetyl chloride according to General Procedure 7.B.
45 g With zinc(II) chloride; In 1,2-dichloro-ethane; at 0 - 20℃; for 3h; 50 g (0.6 mol) of acetyl chloride was added dropwise to 85 g of paraformaldehyde and 1.75 g of zinc chloride mixture after cooling to 0 C, and the addition was completed in about 2 hr, and then the reaction system was allowed to rise to room temperature for 1 hr.Then, the mixture was heated to 90 C for further 10 hr, cooled, filtered to remove solids, and distilled under reduced pressure to give Intermediate F-1 45 g.

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  • 3-chloro-2-chloromethyl-3-methyl-pentane-1,5-diol [ No CAS ]
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  • [ 4984-82-1 ]
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  • 1-(hydroxymethyl)theobromine [ No CAS ]
  • 1-(acetoxymethyl)theobromine [ No CAS ]
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  • [ 70684-84-3 ]
  • 3,6-Dihydro-2H-pyridine-1,4-dicarboxylic acid 4-acetoxymethyl ester 1-tert-butyl ester [ No CAS ]
  • 74
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  • [ 894806-43-0 ]
  • 2-Ethoxy-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid acetoxymethyl ester [ No CAS ]
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  • 6-mercaptopurine [ No CAS ]
  • [ 111621-57-9 ]
  • [ 111621-56-8 ]
  • 76
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  • [ 13398-11-3 ]
YieldReaction ConditionsOperation in experiment
12% With sodium iodide; In acetonitrile; at 20℃; for 15h;Darkness; Sodium iodide (27.6g, 0.18 mol) was added to a solution of chloromethylacetate (6.6 g, 0.06 mol) in acetonitrile (66 mE). The reacCompoundtion flask was covered in aluminum foil to exclude light andstirred at ambient temperature for 15 hours. The reactionmixture was partition between dichioromethane and water,andthe aqueous layerwas extracted with dichloromethane.The combine organics were washed with aqueous satu3.55rated NaHCO3, 10% aqueous sodium sulfite solution, andbrine then dried with sodium sulphate and concentrated togive the product (1.13 g, 12% yield) as a yellow oil.
15.5 g With sodium iodide; In acetonitrile; at 20℃; for 24h;Darkness; To a mixture of Nal (29.0 g) and acetonitrile (140 mL) was added <strong>[625-56-9]chloromethyl acetate</strong> (3al; 20.0 g) dropwise at 20 C in the dark. The reaction was stirred at ambient temperature for 24 hours. The resulting mixture was partitioned between methyl ferf-butyl ether (MTBE; 160 mL) and water (200 mL), and the aqueous layer was extracted with MTBE (150 mL). The combined organic layers were washed successively with saturated aqueous sodium bicarbonate (200 mL), 10 percent aqueous sodium sulfite solution (200 mL), and saturated aqueous sodium chloride (100 mL) before it was dried over sodium sulphate, filtered, and concentrated to afford iodomethyl acetate (3a; 15.5 g) sufficiently pure for the next step.
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  • [ 49805-30-3 ]
  • [ 183074-62-6 ]
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  • [ 625-56-9 ]
  • 2-Oxo-2H-chromene-3-carboxylic acid acetoxymethyl ester [ No CAS ]
  • 85
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  • 2-Amino-3-hydroxy-propionic acid benzyl ester; compound with toluene-4-sulfonamide [ No CAS ]
  • 2-(2-Acetoxy-acetylamino)-3-hydroxy-propionic acid benzyl ester [ No CAS ]
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