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Chemical Structure| 6269-47-2 Chemical Structure| 6269-47-2

Structure of 6269-47-2

Chemical Structure| 6269-47-2

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Product Details of [ 6269-47-2 ]

CAS No. :6269-47-2
Formula : C14H11NOS
M.W : 241.31
SMILES Code : COC1=CC=CC=C1C2=NC3=CC=CC=C3S2

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Application In Synthesis of [ 6269-47-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6269-47-2 ]

[ 6269-47-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6609-56-9 ]
  • [ 137-07-5 ]
  • [ 6269-47-2 ]
YieldReaction ConditionsOperation in experiment
51% With zinc(II) acetate dihydrate; In neat (no solvent); at 120℃; under 7600.51 Torr; for 18h;Autoclave; Inert atmosphere; Green chemistry; General procedure: Zn(OAc)2·2H2O (5.0 mol%) was transferred to a 100 mL autoclavereactor equipped with an overhead stirrer and an automatic temperature-control system. The appropriate benzene-1,2-diamine 1 (2 mmol), DMF (10.0 mmol), and PMHS (5.0 mmol)were successively introduced. The reactor was sealed, flushedthree times with N2 (10 atm), and heated to the required temperature with vigorous stirring (600 rpm). During the course ofthe reaction, an increase of pressure was observed, due to thegeneration of Me2NH and HCHO at 120 C.15 (For this reason, the protocol needs to be performed in a sealed high-pressurereactor.) When the reaction was complete, the autoclave wascooled to r.t., and the pressure generated during the reactionwas carefully released. Basic hydrolysis was then carried out atr.t. for 30 min to remove unreacted PMHS from the mixture.13aThe mixture was then extracted with EtOAc (3 × 20 mL). Thecombined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo. The crude products were further purified bycolumn chromatography [silica gel (100-200 mesh), PE-EtOAc(20:4 to 10:2)]. The spectroscopic data for the products wereconsistent with those reported in the literature.
 

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