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[ CAS No. 627463-18-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 627463-18-7
Chemical Structure| 627463-18-7
Structure of 627463-18-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 627463-18-7 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 627463-18-7 ]

SDS

Product Details of [ 627463-18-7 ]

CAS No. :627463-18-7MDL No. :MFCD16619427
Formula :C8H8BrFBoiling Point :201.7°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :203.05Pubchem ID :22641057
Synonyms :

Computed Properties of [ 627463-18-7 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 627463-18-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 627463-18-7 ]

  • Downstream synthetic route of [ 627463-18-7 ]

[ 627463-18-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 627463-17-6 ]
  • [ 627463-18-7 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In ethyl acetate; under 760.051 Torr; 4-Bromo-2-fluoro-1-vinyl-benzene (1.80 g, 8.96 mmol) was dissolved in ethyl acetate (50 mL) and palladium-on-carbon (10%, 70 mg) was added and the mixture was hydrogenated under 1 atmosphere overnight. The mixture was filtered and the filtrate was concentrated to give the crude, 1.80 g, which was used directly for the next step.
  • 2
  • [ 627463-18-7 ]
  • [ 1066-54-2 ]
  • [ 627463-19-8 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; lithium chloride;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In DMF (N,N-dimethyl-formamide); at 60.0℃; for 3.0h; To a stirred solution of [627463-18-7]4-bromo-1-ethyl-2-fluoro-benzene (1.80 g, 8.86 mmol) in N,N-dimethylformamide (20 mL), under a nitrogen atmosphere was added PdCl2(PPh3)2, CuI, and LiCl. The mixture was stirred at 60 C. for 3 hours, then poured into water and extracted with ether (3*20 mL). The extract was dried (Na2SO4) and concentrated. The residue was filtered through a pad of silica gel eluding with hexanes. Removal of solvent gave the crude, 1.67 g, which was used for the next step.
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