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Chemical Structure| 628-97-7 Chemical Structure| 628-97-7

Structure of Ethyl palmitate
CAS No.: 628-97-7

Chemical Structure| 628-97-7

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Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of the normal human dietary fat intake.

Synonyms: Ethyl hexadecanoate; Palmitic Acid ethyl ester

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Product Details of Ethyl palmitate

CAS No. :628-97-7
Formula : C18H36O2
M.W : 284.48
SMILES Code : CCCCCCCCCCCCCCCC(OCC)=O
Synonyms :
Ethyl hexadecanoate; Palmitic Acid ethyl ester
MDL No. :MFCD00008996
InChI Key :XIRNKXNNONJFQO-UHFFFAOYSA-N
Pubchem ID :12366

Safety of Ethyl palmitate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Polymorphonuclear leukocytes (PMN) 1.1 μM 50 minutes Evaluate the inhibitory effect of ethyl palmitate on ROS production in PMNs, showing significant inhibition of ROS production with an IC50 value of 1.1 μM. Molecules. 2016 Jan 5;21(1):9
Polymorphonuclear leukocytes (PMN) 3.7 μM 1 hour Evaluate the inhibitory effect of ethyl palmitate on PMN chemotaxis, showing significant inhibition of PMN migration with an IC50 value of 3.7 μM. Molecules. 2016 Jan 5;21(1):9

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6N male mice Ethyl palmitate and LPS-induced hepatotoxicity model Intraperitoneal injection 300 mM ethyl palmitate Single administration, results observed after 24 hours Evaluate the protective effects of dantrolene and DUB on ethyl palmitate-induced hepatotoxicity, showing both significantly reduced hepatocyte death and mitochondrial ROS accumulation Cell Death Discov. 2023 Mar 21;9(1):100

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03574701 Olfactory Disorder Not Applicable Recruiting December 25, 2022 Canada, British Columbia ... More >> St Paul Hospital Recruiting Vancouver, British Columbia, Canada, V6Z 1Y6 Contact: Sara Derikvand, PhD    6048069926    stpaulsinusresearch@gmail.com    Principal Investigator: Amin R Javer, MD          St Paul Sinus Centre Recruiting Vancouver, British Columbia, Canada, V6Z 1Y6 Contact: Amin Javer, MD    6048069926    sinusdoc@me.com    Contact: Sara Derikvand, PhD    6048069926    stpaulsinusresearch@gmail.com Less <<
NCT01686568 Insulin Resistance Phase 3 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT01686568 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.15mL

7.03mL

3.52mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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