630128-01-7|(S)-1-Benzyl 6-methyl 2-((tert-butoxycarbonyl)amino)-4-oxohexanedioate| Ambeed

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Quality Control of [ 630128-01-7 ] Purity: 98% SDS Specification

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Product Details of [ 630128-01-7 ]

CAS No. :	630128-01-7
Formula :	C₁₉H₂₅NO₇
M.W :	379.40
SMILES Code :	O=C(OCC1=CC=CC=C1)[C@@H](NC(OC(C)(C)C)=O)CC(CC(OC)=O)=O
MDL No. :	MFCD30470618

Safety of [ 630128-01-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 630128-01-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 630128-01-7 ]

[ 630128-01-7 ] Synthesis Path-Downstream 1~39

1
[ 67-56-1 ]
[ 844644-72-0 ]
[ 630128-01-7 ]

Yield	Reaction Conditions	Operation in experiment
71.5%	In toluene; at 70℃; for 16h;Large scale;	Into a 50 L reactor, anhydrous toluene (20 L) was added. Compound 3 (6.95 kg, 15.46 mol) was added. Anhydrous methanol (6.26 L, 154.6 mol) was added under stirring. The internal temperature of the reactor was controlled at 70 C. and the feed liquid was stirred for 16 h. Sampling test was performed by TLC (PE:EtOAc=1:1). After completion of the reaction, the reaction solution was concentrated under reduced pressure to give a red brown viscous liquid. The crude product was dissolved in 6 L EtOH and 10 L petroleum ether. The solution was stirred at 13 C. for 30 minutes with a white solid to be precipitated. After stirring for 2 hours, the solution was allowed to stand overnight and filtered, and the solid was washed three times with petroleum ether (5 L) and then dried to give compound 4 as a product (4.2 kg, 11.07 mol), with a yield of 71.5% and purity of 98%.

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.
[2]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.
[3]Patent: US2020/39992,2020,A1 .Location in patent: Paragraph 0138; 0141.

2
[ 630128-01-7 ]
[ 630128-03-9 ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

3
[ 55628-54-1 ]
[ 630128-01-7 ]
[ 766514-49-2 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

4
[ 80040-79-5 ]
[ 630128-01-7 ]
1-O-2-S-[1'-benzyloxycarbonyl-2'-(4'-t-butoxycarbonylamino)-benzylpropionate-1'-2'-ethenyl]-3,4,6-tri-O-benzyl-α-D-galactopyranoside [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

5
[ 630128-01-7 ]
[ 766514-61-8 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

6
[ 630128-01-7 ]
(2R,3R,4S,4aR,7S,9aR)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-oxo-3,4,4a,5,6,7,8,9a-octahydro-2H-1,9-dioxa-10-thia-6-aza-anthracene-7-carboxylic acid benzyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

7
[ 630128-01-7 ]
[ 766514-60-7 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

8
[ 630128-01-7 ]
[ 766514-54-9 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

9
[ 630128-01-7 ]
(4aR,6R,7R,8S,8aR)-3-((S)-2-Acetylamino-2-methoxycarbonyl-ethyl)-7,8-bis-benzyloxy-6-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid methyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

10
[ 630128-01-7 ]
(4aR,6R,7R,8S,8aR)-3-((S)-2-Acetylamino-2-methoxycarbonyl-ethyl)-7,8-bis-benzyloxy-6-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid methyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

11
[ 630128-01-7 ]
(4aR,6R,7R,8S,8aR)-7,8-Bis-benzyloxy-3-[(S)-2-benzyloxycarbonyl-2-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-ethyl]-6-benzyloxymethyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid methyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

12
[ 630128-01-7 ]
3-[2-[1-benzyloxycarbonyl-2-(7,8-bis-benzyloxy-6-benzyloxymethyl-2-methoxycarbonyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalen-3-yl)-ethylcarbamoyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-indole-1-carboxylic acid tert-butyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 6153 - 6155.

13
[ 30925-18-9 ]
[ 630128-01-7 ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.
[2]Heteroatom Chemistry,2015,vol. 26,p. 367 - 373.
[3]Patent: US2018/312512,2018,A1 .
[4]Patent: US2020/39992,2020,A1 .

14
[ 630128-01-7 ]
[ 630128-05-1 ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

15
[ 630128-01-7 ]
(S)-5-tert-Butoxycarbonylamino-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylsulfanyl)-3-[(Z)-2-trimethylsilanyl-ethanesulfonylimino]-hexanedioic acid 6-benzyl ester 1-methyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

16
[ 630128-01-7 ]
6,7-bis-benzyloxy-8-benzyloxymethyl-2-tert-butoxycarbonylamino-1-oxo-2,3,5a,7,8,9a-hexahydro-1H,6H-9-oxa-5-thia-9b-aza-cyclopenta[a]naphthalene-4-carboxylic acid methyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

17
[ 630128-01-7 ]
(2R,3R,4S,4aR,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-oxo-2,3,4,4a,5,6,7,8,9,9a-decahydro-1-oxa-10-thia-6,9-diaza-anthracene-7-carboxylic acid benzyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

18
[ 630128-01-7 ]
(2R,3R,4S,4aR,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-oxo-2,3,4,4a,5,6,7,8,9,9a-decahydro-1-oxa-10-thia-6,9-diaza-anthracene-7-carboxylic acid benzyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

19
[ 630128-01-7 ]
[ 630128-10-8 ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

20
[ 630128-01-7 ]
[ 630128-07-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

21
[ 630128-01-7 ]
(4aS,6R,7R,8S,8aR)-7,8-Bis-benzyloxy-3-((S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-6-benzyloxymethyl-4-(2-trimethylsilanyl-ethanesulfonyl)-4,4a,6,7,8,8a-hexahydro-5-oxa-1-thia-4-aza-naphthalene-2-carboxylic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

22
[ 630128-01-7 ]
(4aS,6R,7R,8S,8aR)-3-((S)-2-Amino-2-benzyloxycarbonyl-ethyl)-7,8-bis-benzyloxy-6-benzyloxymethyl-4-(2-trimethylsilanyl-ethanesulfonyl)-4,4a,6,7,8,8a-hexahydro-5-oxa-1-thia-4-aza-naphthalene-2-carboxylic acid methyl ester; compound with trifluoro-acetic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 3021 - 3027.

23
[ 343338-29-4 ]
[ 630128-01-7 ]
[ 1186468-33-6 ]