[ CAS No. 63024-26-0 ] {[proInfo.proName]}

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Quality Control of [ 63024-26-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 63024-26-0 ]

SDS Specification

Alternatived Products of [ 63024-26-0 ]

Product Details of [ 63024-26-0 ]

CAS No. :	63024-26-0	MDL No. :	MFCD08458519
Formula :	C₁₄H₁₆ClNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	265.74	Pubchem ID :	-
Synonyms :

Safety of [ 63024-26-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 63024-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 63024-26-0 ]
Downstream synthetic route of [ 63024-26-0 ]

[ 63024-26-0 ] Synthesis Path-Upstream 1~11

1
[ 176896-73-4 ]
[ 63024-26-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With hydrogenchloride In ethyl acetate for 2.5 h;	Step B: (2S)-2-tert-Butoxycarbonylamino-3-(2-naphthyl)propionic acid methyl ester (5.52 g, theoretically 15.85 mmol) is dissolved in 20 ml of ethyl acetate in a 500 ml flask equipped with a magnetic stirrer. To the stirred solution is added 80 ml of 2.8 M hydrogen chloride in ethyl acetate and the reaction is stirred for 2.5 hours under nitrogen. The clear mixture is concentrated in vacuo to give a solid, which is taken up in ethyl acetate, stirred for 10 min and filtered. The solid is dried in vacuo at 40° C. to give 3.91 g (93percent) of (2S)-2-Amino-3-(2-naphthyl)propionic acid methyl ester hydrochloride as a white solid. HPLC-MS: Rt=3.70 min., (M+1)=230, percent Area by ELS=100

Reference： [1] Patent: US2007/185128, 2007, A1, . Location in patent: Page/Page column 27

2
[ 7647-01-0 ]
[ 176896-73-4 ]
[ 63024-26-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	for 2.5 h; Magnetic stirrer	(2S)-2-tert-butoxycarbonylamino-3-(2-naphthyl)propionic acid methyl ester (5.52 g, theoretically 15.85 mmol) is dissolved in 20 ml of ethyl acetate in a 500 ml flask equipped with a magnetic stirrer. To the stirred solution is added 80 ml of 2.8 M hydrogen chloride in ethyl acetate and the reaction is stirred for 2.5 hours under nitrogen. The clear mixture is concentrated in vacuo to give a solid, which is taken up in ethyl acetate, stirred for 10 min and filtered. The solid is dried in vacuo at 40 C to give 3.91 g (93 percent) of (2S)-2-amino-3-(2-naphthyl)propionic acid methyl ester hydrochloride as a white solid. HPLC-MS: Rt = 3.70 min. , (M+1) = 230, percent Area by ELS = 100

Reference： [1] Patent: WO2004/48345, 2004, A2, . Location in patent: Page 52

3
[ 67-56-1 ]
[ 6960-34-5 ]
[ 63024-26-0 ]

Reference： [1] Bulletin of the Chemical Society of Japan, 1986, vol. 59, # 7, p. 2195 - 2202
[2] Synthetic Communications, 1995, vol. 25, # 21, p. 3407 - 3411

4
[ 67-56-1 ]
[ 63024-26-0 ]