[ CAS No. 6306-60-1 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 6306-60-1
Chemical Structure| 6306-60-1
Structure of 6306-60-1

Quality Control of [ 6306-60-1 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 6306-60-1 ]

SDS

Product Details of [ 6306-60-1 ]

CAS No. :6306-60-1MDL No. :MFCD00001899
Formula :C8H5Cl2NBoiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :186.04Pubchem ID :-
Synonyms :

Computed Properties of [ 6306-60-1 ]

TPSA : 23.8 H-Bond Acceptor Count : 1
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.13 Rotatable Bond Count : 1

Safety of [ 6306-60-1 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 6306-60-1 ]

  • Upstream synthesis route of [ 6306-60-1 ]
  • Downstream synthetic route of [ 6306-60-1 ]

[ 6306-60-1 ] Synthesis Path-Upstream   1~12

  • 1
  • [ 773837-37-9 ]
  • [ 94-99-5 ]
  • [ 6306-60-1 ]
YieldReaction ConditionsOperation in experiment
84% With polyethylene glycol functionalized magnetic dicationic ionic liquid In water for 1.25 h; Reflux; Green chemistry General procedure: To amixture of the benzyl halide (1.0mmol) and NaCN (2mmol) inwater (5 mL), PEG-MDIL (0.2 g) was added. The suspension was magneticallystirred under reflux conditions for the time shown in Table 2.After completion of the reaction, the mixture was extracted with ether(2 × 10 mL). The combined organic extracts (dried over CaCl2) wereevaporated under reduced pressure. The desired benzyl cyanide wasobtained in good to excellent isolated yields (Scheme 3).
82% With β-cyclodextrin-polyurethane polymercoated Fe3O4 magnetic nanoparticle In water at 90℃; for 1.25 h; General procedure: To a mixture of the benzyl halide (1.0 mmol) and MY (Y:N3, SCN, OAc, CN) (2 mmol) in water (5 ml), -CDPU-MNPs (0.1 g) was added. The suspension was magnetically stirred under reflux conditions for the time shown in Table 1. After complete consumption of starting material as judged by TLC (using n-hexane–ethylacetate as eluent), the catalyst was concentrated on the sidewall of the reaction vessel using an external magnet, the aqueous phase was separated by decantation and extracted with diethyl ether (2× 10 mL). The extracted was dried with calcium chloride (CaCl2) and evaporated in vacuo to give corresponding product. The residual catalyst in the reaction vessel was washed and dried and then subjected to the next run directly.
Reference: [1] Organic Preparations and Procedures International, 2011, vol. 43, # 3, p. 285 - 291
[2] Journal of Molecular Liquids, 2015, vol. 202, p. 34 - 39
[3] Journal of Molecular Catalysis A: Chemical, 2012, vol. 365, p. 80 - 86
[4] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[5] Catalysis Communications, 2012, vol. 18, p. 102 - 105
  • 2
  • [ 877468-98-9 ]
  • [ 10442-39-4 ]
  • [ 6306-60-1 ]
YieldReaction ConditionsOperation in experiment
82% at 135 - 140℃; for 0.08 h; Microwave irradiation General procedure: A mixture of MOM–ethers (1 mmol) [Bu4N][X](2 mmol) was added to [Hmim][NO3] (0.4 mmol) (and exposed to MWirradiation (All reactions were carried out at 135-140 oC with 170 Wapplied power). After completion of the reactions (monitored by TLC, eluent:n–hexane/ethyl acetate, 5:1), the mixture was extracted with Et2O(3×10 mL). The organic phase was dried over anhydrous Na2SO4and rotary evaporation afforded a residue, which was then passed through ashort pad of neutral alumina (n–hexane/ethyl acetate, 5:1, 75 mL) to obtain thehighly pure products. The spectral data were inaccordance with those reported in the literature:
Reference: [1] Comptes Rendus Chimie, 2010, vol. 13, # 12, p. 1468 - 1473
[2] Tetrahedron Letters, 2010, vol. 51, # 25, p. 3274 - 3276
[3] Tetrahedron Letters, 2014, vol. 55, # 32, p. 4424 - 4426
  • 3
  • [ 19719-28-9 ]
  • [ 6306-60-1 ]
Reference: [1] Tetrahedron Letters, 2008, vol. 49, # 5, p. 914 - 918
  • 4
  • [ 773837-37-9 ]
  • [ 20443-99-6 ]
  • [ 6306-60-1 ]
Reference: [1] Patent: CN106117028, 2016, A. Location in patent: Paragraph 0059; 0060
[2] Applied Organometallic Chemistry, 2018, vol. 32, # 4,
  • 5
  • [ 1058649-24-3 ]
  • [ 10442-39-4 ]
  • [ 6306-60-1 ]
Reference: [1] Tetrahedron Letters, 2010, vol. 51, # 25, p. 3274 - 3276
  • 6
  • [ 151-50-8 ]
  • [ 94-99-5 ]
  • [ 6306-60-1 ]
Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 2837,2842
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3763,3766
[3] Collection of Czechoslovak Chemical Communications, 1964, vol. 29, p. 776 - 794
[4] Patent: US2479295, 1946,
  • 7
  • [ 143-33-9 ]
  • [ 94-99-5 ]
  • [ 6306-60-1 ]
Reference: [1] Phytochemistry (Elsevier), 1988, vol. 27, # l, p. 51 - 72
[2] Chimia, 2003, vol. 57, # 11, p. 697 - 701
  • 8
  • [ 1777-82-8 ]
  • [ 6306-60-1 ]
Reference: [1] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350
[2] Patent: CN106117028, 2016, A
  • 9
  • [ 6574-98-7 ]
  • [ 6306-60-1 ]
Reference: [1] Patent: CN106117028, 2016, A
  • 10
  • [ 50-84-0 ]
  • [ 6306-60-1 ]
Reference: [1] Patent: CN106117028, 2016, A
  • 11
  • [ 95-73-8 ]
  • [ 6306-60-1 ]
Reference: [1] Collection of Czechoslovak Chemical Communications, 1964, vol. 29, p. 776 - 794
  • 12
  • [ 151-50-8 ]
  • [ 20443-99-6 ]
  • [ 6306-60-1 ]
Reference: [1] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350
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