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Chemical Structure| 632297-52-0 Chemical Structure| 632297-52-0

Structure of 632297-52-0

Chemical Structure| 632297-52-0

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Product Details of [ 632297-52-0 ]

CAS No. :632297-52-0
Formula : C9H17IN2OSi
M.W : 324.23
SMILES Code : C[Si](CCOCN1N=CC=C1I)(C)C

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Application In Synthesis of [ 632297-52-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 632297-52-0 ]

[ 632297-52-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 76513-69-4 ]
  • [ 4522-35-4 ]
  • [ 632297-52-0 ]
  • 3-iodo-1-SEM-1H-pyrazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
NaH (60% dispersion in mineral oil, 143 mg, 3.57 mmol) was added to a stirred solution of 3-iodo-lH-pyrazole [4522-35-4] (659 mg, 4.00 mmol) in DMF (20 mL) at 0 C under N2 atmosphere. The mixture was stirred at room temperature for 30 min. 2- (Trimethylsilyl)ethoxymethyl chloride [76513-69-4] (0.66 mL, 3.74 mmol) was added at 0 C and the reaction mixture was stirred at room temperature for 16 h. The mixture was diluted with water and extracted with EtOAc. The organic layer was dried (MgS04), filtered and the solvents were evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in heptane, gradient from 0/100 to 10/90). The desired fractions were collected and concentrated in vacuo to afford a mixture of 1-188 and 1-189 (965 mg, 86%).
 

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