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[ CAS No. 651341-68-3 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 651341-68-3

Chemical Structure| 651341-68-3

Chemical Structure| 651341-68-3

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Quality Control of [ 651341-68-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 651341-68-3 ]

SDS Specification

Alternatived Products of [ 651341-68-3 ]

Product Details of [ 651341-68-3 ]

CAS No. :	651341-68-3	MDL No. :	MFCD06204924
Formula :	C₉H₈BrFO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FYSROUWCKUYSAP-UHFFFAOYSA-N
M.W :	247.06	Pubchem ID :	21983528
Synonyms :

Calculated chemistry of [ 651341-68-3 ]

Physicochemical Properties

Num. heavy atoms :	13
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.22
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	50.19
TPSA :	26.3 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.71 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.2
Log Po/w (XLOGP3) :	2.96
Log Po/w (WLOGP) :	3.19
Log Po/w (MLOGP) :	3.38
Log Po/w (SILICOS-IT) :	3.14
Consensus Log Po/w :	2.97

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.38
Solubility :	0.103 mg/ml ; 0.000417 mol/l
Class :	Soluble
Log S (Ali) :	-3.18
Solubility :	0.165 mg/ml ; 0.000668 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.02
Solubility :	0.0238 mg/ml ; 0.0000964 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.75

Safety of [ 651341-68-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 651341-68-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 651341-68-3 ]
Downstream synthetic route of [ 651341-68-3 ]

[ 651341-68-3 ] Synthesis Path-Upstream 1~3

1
[ 64-17-5 ]
[ 1006-41-3 ]
[ 651341-68-3 ]

Yield	Reaction Conditions	Operation in experiment
87%	for 24 h; Reflux	2-bromo-4-fluoro benzoic acid (2.37g, 10.82mmol) wasdissolved in ethanol (100 mL). To which was added thionyl chlorine (1.57mL,21.64mmol) and stirred at reflux for 24 hours. After termination of the reaction, the reaction was cooled to room temperature. The reaction wasconcentrated under reduced pressure to remove the solvent. Washed with water and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filteredand concentrated. The resulting residue was purified by column chromatographyto produce the title compound (2.29g, 87percent).

Reference： [1] Patent: CN105555761, 2016, A, . Location in patent: Paragraph 0358; 0359; 0360

2
[ 451-46-7 ]
[ 651341-68-3 ]

Reference： [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 16, p. 4440 - 4444[2] Angew. Chem., 2013, vol. 125, # 16, p. 4536 - 4540,5

3
[ 64-17-5 ]
[ 95383-36-1 ]
[ 651341-68-3 ]

Reference： [1] Patent: WO2004/9589, 2004, A1, . Location in patent: Page/Page column 55-56

[ 651341-68-3 ] Synthesis Path-Downstream 1~21

1
[ 64-17-5 ]
[ 95383-36-1 ]
[ 651341-68-3 ]

Reference： [1]Patent: WO2004/9589,2004,A1 .Location in patent: Page/Page column 55-56

2
[ 451-46-7 ]
[ 651341-68-3 ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 4440 - 4444
Angew. Chem.,2013,vol. 125,p. 4536 - 4540,5

3
[ 64-17-5 ]
[ 1006-41-3 ]
[ 651341-68-3 ]

Yield	Reaction Conditions	Operation in experiment
97.2%	With sulfuric acid; at 15 - 85℃;	To a 2-bromo-4-fluorobenzoic acid [13a] (22.8 mmol, 5.0 g) in ethanol (50 mL) was added sulfuric acid (22.8 mmol, 2.2 g) at 15 to 25 C. The reaction mixture was stirred at 80 to 85 C overnight, and the reaction was monitored by TLC. After completion, the reaction mixture was quenched with 10 wt% aq. Na^CO, solution and extracted with DCM three times. The combined organic layers were dried over anhydrous Na^SCft. The solvent was evaporated under reduced pressure to afford ethyl 2-bromo-4-fluorobenzoate [14a] in 97.2% yield (5.5 g) as a yellow oil, which was used for the next step without further purification. 'H NMR (600 MHz, CDCft) d 7.87 (dd, J = 8.4, 6.0 Hz, 1H), 7.41 (dd, J = 8.4, 2.4 Hz, 1H), 7.07-7.10 (m, 1H), 4.40 (q, J= 7.2 Hz, 2H), 1.41 (t, J= 7.2 Hz, 3H); 13C NMR (150 MHz, CDCft) d 165.0, 163.6 (d, CF = 255.2 Hz), 133.2 (d, CF = 9.3 Hz), 128.3 (d, CF = 3.5 Hz), 122.9 (d, CF = 9.9 Hz); 121.7 (d, CF = 24.5 Hz), 114.4 (d, CF = 21.2 Hz), 61.6, 14.1; 19F (0282) NMR (564 MHz, CDC13) d -106.1.
87%	With thionyl chloride; for 24h;Reflux;	2-bromo-4-fluoro benzoic acid (2.37g, 10.82mmol) wasdissolved in ethanol (100 mL). To which was added thionyl chlorine (1.57mL,21.64mmol) and stirred at reflux for 24 hours. After termination of the reaction, the reaction was cooled to room temperature. The reaction wasconcentrated under reduced pressure to remove the solvent. Washed with water and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filteredand concentrated. The resulting residue was purified by column chromatographyto produce the title compound (2.29g, 87%).

Reference： [1]Patent: WO2019/200114,2019,A1 .Location in patent: Page/Page column 41-42
[2]Patent: CN105555761,2016,A .Location in patent: Paragraph 0358; 0359; 0360

4
[ 651341-68-3 ]
2-(1-methylpyrrolidin-2-yl)ethyl(3'-chloro-5-fluoro[1,1'-biphenyl]-2-yl)amino formic acid [ No CAS ]

Reference： [1]Patent: CN105555761,2016,A

5
[ 651341-68-3 ]
3'-chloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid [ No CAS ]

Reference： [1]Patent: CN105555761,2016,A

6
[ 651341-68-3 ]
[ 63503-60-6 ]
3'-chloro-5-fluoro-[1,1'-biphenyl]-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In toluene; at 100℃; for 6h;	The prepared <strong>[651341-68-3]2-bromo-4-fluoro-benzoic acid ethyl ester</strong> instep 1 (1.1g, 4.47mmol) was dissolved in toluene (20mL). To which was added 3-chlorophenyl boronic acid (766mg, 4.90mmol), potassium carbonate (1.23g,8.90mmol) and tetrakis (triphenylphosphine) palladium (520mg, 0.44mmol). The reaction was stirred for 6 hours at 100 deg. C, and cooled to room temperature. Which was filtered through celite, and the reaction was concentrated under reduced pressure to remove the solvent. Washed with water and extracted with ethyl acetate. The organic layer was dried overanhydrous magnesium sulfate, filtered and concentrated. The resulting residuewas purified by column chromatography to produce the title compound (850mg, 69%).

Reference： [1]Patent: CN105555761,2016,A .Location in patent: Paragraph 0361; 0362; 0363

7
[ 651341-68-3 ]
[ 693-02-7 ]
3-butyl-6-fluoro-4-(3-oxobutyl)-1H-isochromen-1-one [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2016,vol. 2016,p. 663 - 667

8
[ 651341-68-3 ]
[ 693-02-7 ]
C₁₅H₁₇FO₂ [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2016,vol. 2016,p. 663 - 667

9
[ 651341-68-3 ]
(S)-1-(((S)-tert-butylsulfinyl)amino)-7-fluoro-2,3-dihydro-1H-indene-4-carboxylic acid [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1
[5]Patent: WO2019/200114,2019,A1
[6]Patent: WO2019/200114,2019,A1
[7]Patent: WO2019/200114,2019,A1
[8]Patent: WO2019/200114,2019,A1

10
[ 651341-68-3 ]
ethyl (S)-1-(((S)-tert-butylsulfinyl)amino)-7-fluoro-2,3-dihydro-1H-indene-4-carboxylate [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1

11
[ 651341-68-3 ]
ethyl 7-fluoro-1-oxo-2,3-dihydro-1H-indene-4-carboxylate [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1

12
[ 651341-68-3 ]
(S)-1-amino-N-(3-chloro-4-fluorophenyl)-7-fluoro-2,3-dihydro-1H-indene-4-carboxamide hydrochloride [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1
[5]Patent: WO2019/200114,2019,A1
[6]Patent: WO2019/200114,2019,A1
[7]Patent: WO2019/200114,2019,A1
[8]Patent: WO2019/200114,2019,A1

13
[ 651341-68-3 ]
3-(2-(ethoxycarbonyl)-5-fluorophenyl)propanoic acid [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1

14
[ 651341-68-3 ]
(E)-3-(2-(ethoxycarbonyl)-5-fluorophenyl)acrylic acid [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1

15
[ 651341-68-3 ]
ethyl 2-(3-(tert-butoxy)-3-oxopropyl)-4-fluorobenzoate [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1

16
[ 651341-68-3 ]
O-(1-methyl-1H-1,2,4-triazol-3-yl)methyl N-(S)-(4-((3-chloro-4-fluorophenyl)carbamoyl)-7-fluoro-2,3-dihydro-1H-inden-1-yl)carbamate [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1
[5]Patent: WO2019/200114,2019,A1
[6]Patent: WO2019/200114,2019,A1
[7]Patent: WO2019/200114,2019,A1
[8]Patent: WO2019/200114,2019,A1
[9]Patent: WO2019/200114,2019,A1
[10]Patent: WO2019/200114,2019,A1
[11]Patent: WO2019/200114,2019,A1
[12]Patent: WO2019/200114,2019,A1
[13]Patent: WO2019/200114,2019,A1
[14]Patent: WO2019/200114,2019,A1
[15]Patent: WO2019/200114,2019,A1
[16]Patent: WO2019/200114,2019,A1

17
[ 651341-68-3 ]
(S)-1-amino-N-(3-chloro-4-fluorophenyl)-7-fluoro-2,3-dihydro-1H-indene-4-carboxamide hydrochloride [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1
[5]Patent: WO2019/200114,2019,A1
[6]Patent: WO2019/200114,2019,A1
[7]Patent: WO2019/200114,2019,A1
[8]Patent: WO2019/200114,2019,A1

18
[ 651341-68-3 ]
(S)-1-(((S)-tert-butylsulfinyl)amino)-N-(3-chloro-4-fluorophenyl)-7-fluoro-2,3-dihydro-1H-indene-4-carboxamide [ No CAS ]

Reference： [1]Patent: WO2019/200114,2019,A1
[2]Patent: WO2019/200114,2019,A1
[3]Patent: WO2019/200114,2019,A1
[4]Patent: WO2019/200114,2019,A1
[5]Patent: WO2019/200114,2019,A1
[6]Patent: WO2019/200114,2019,A1
[7]Patent: WO2019/200114,2019,A1
[8]Patent: WO2019/200114,2019,A1

19
[ 651341-68-3 ]
[ 2495-35-4 ]
ethyl (E)-2-(3-(benzyloxy)-3-oxoprop-1-en-1-yl)-4-fluorobenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With tetrabutylammomium bromide; sodium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 100 - 105℃; for 5h;Schlenk technique; Inert atmosphere;	To a schlenk tube were added NaOAc (24.3 mmol, 2.0 g), tetrabutylammonium bromide (TBAB) (0.8 mmol, 260 mg), and Pd(OAc)2 (0.2 mmol, 54.5 mg) at room temperature under nitrogen atmosphere. A solution of <strong>[651341-68-3]ethyl 2-bromo-4-fluorobenzoate</strong> [14a] (8.1 mmol, 2.0 g) and benzyl acrylate [15a] (16.2 mmol, 2.6 g) in DMAc (40 mL) was added to the reaction mixture. The reaction mixture was stirred at 100 to 105 C for 5 hours and then cooled to room temperature. The reaction mixture was quenched with purified water and extracted with ethyl acetate three times. The combined organic layers were dried over anhydrous Na2S04. After the solvent was evaporated under reduced pressure, the residue was purified by column chromatography on silica gel by eluting with ethyl acetate/hexanes (v/v, 1/5) to afford ethyl (E)-2-(3-(benzyloxy)-3-oxoprop-l-en-l-yl)-4-fluorobenzoate [16a] in 94.0 % yield (2.5 g) as ayellow oil. XH NMR (600 MHz, CDCl3) d 8.48 (d, J= 16.2 Hz, 1H), 8.01 (dd, J= 9.0, 6.0 Hz, 1H), 7.42 (d, J= 6.6 Hz, 2H), 7.38 (t , J= 7.8 Hz, 2H), 7.33 (t, J= 3.0 Hz, 3H), 7.25 (dd, J= 9.6, 3.0 Hz, 1H), 7.10-7.13 (m, 1H), 6.32 (d, J= 15.6 Hz, 1H), 5.26 (s, 2H), 4.37 (q, J= 7.2 Hz, 2H), 1.37 (t, J= 7.2 Hz, 3H); 13C NMR (150 MHz, CDCl3) d 165.9, 165.8, 164.7 (d, JC F = 252.2 Hz), 143.3 (d, JC F = 1.8 Hz), 139.2 (d, JC F = 8.6 Hz), 135.9, 133.5 (d, CF = 9.2 Hz), 128.6, 128.3, 128.2, 126.3 (d, CF = 3.0 Hz), 121.6, 116.4 (d, CF = 21.6 Hz), 114.7 (d, CF = 22.7 Hz), 66.5, 61.6, 14.2; 19F NMR (564 MHz, CDC13) d - 106.3; LRMS (ESI) m/z calcd for CI9HI7F04 [M+H]+: 329.11; Found: 329.13.

Reference： [1]Patent: WO2019/200114,2019,A1 .Location in patent: Page/Page column 41-44; 49-50

20
[ 651341-68-3 ]
[ 1663-39-4 ]
(E)-ethyl 2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-4-fluorobenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 45℃; for 20h;Inert atmosphere;	A 500 mL two neck round bottom flask was charged with ethyl 2-bromo-4- fluorobenzoate [14a] (10.0 g, 40.48 mmol) and tert- butyl acrylate [15b], R?=tBu, 10.36 g, 80.96 mmol, 2 eq.) in acetonitrile (200 mL). To it was added Pd(OAc)2 (900 mg, 4.08 mmol, 10 mol%) and Et3N (2l.6g, 202.0 mmol, 5.0 eq), followed by P(o-tolyl)3 (2.4 g, 8.16 mmol, 20 mol%). The flask was evacuated and then filled with nitrogen gas twice. The resulting mixture was stirred at 45 C. The reaction was monitored by TLC. After being stirred for 20 hours, reaction mixture was cooled to room temperature and filtered through CELITE pad. The filtrate was diluted with water (100 mL) and extracted with ethyl acetate (2 x 150 mL). The combined organic layer was dried over Na^SCf and filtered, concentrated under reduced pressure to dryness. The crude was purified by silica gel column chromatography using 3% ethyl acetate in hexane as an eluent to give semi pure (A?)-ethyl 2-(3-(/ -butoy)-3-ooprop- l-en-l-yl)-4-fluorobenzoate [16b] as a light-yellow color liquid ' H NMR (400 MHz, CDCl3): d 8.34 (dd, J = 4.0, 1.2 Hz, 1H), 8.01-7.97 (q, J = 7.2 Hz, 2H),), 7.26-7.23(dd, J = 2.8, 2.4 Hz, lH)7. l l (m, 1H), 6.23 (d, J = 16 Hz, 1H) 4.41 ( m, 2H) 1.56 (s, 9H) 1.42 (t, J = 7.2 Hz, 3H).

Reference： [1]Patent: WO2019/200114,2019,A1 .Location in patent: Page/Page column 47-49

21
[ 651341-68-3 ]
[ 55666-43-8 ]
ethyl 2-(3-(tert-butoxy)-3-oxopropyl)-4-fluorobenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		A 250 mL two neck round bottom flask was charged with tot-butyl 3- bromopropanoate [19a] (12.3 g, 69 mmol, 2 eq.) and Zn (6.7 g, 103.5 mmol, 3.0 eq.) in dry DMF (50 mL). To it was added catalytic amount of iodine (54 mg, 0.426 mmol) at 0 C. After being stirred at room temperature for 2 hours, ethyl 2-bromo-4-fluorobenzoate [14a], (8.5 g, 34.5 mmol), Pd2(dba)3 (1.3 g, 1.38 mmol, 0.04 eq.), and XPhos (2.62 g, 5.52 mmol, 0.16 eq.) were added and the resulting mixture was stirred at 90 C for 16 hours (monitored by TLC). Then the reaction mixture was cooled to room temperature and filtered through CELITE pad. The filtrate was diluted with ethyl acetate (300 mL) and washed with NH4Cl (200 mL) and aqueous ammonia (250 mL). The organic layers were separated, dried over anhydrous Na^SCf. filtered, and concentrated under reduced pressure to dryness. The crude residue was purified by silica-gel column chromatography using 3% ethyl acetate in hexane as an eluent giving semi pure ethyl 2-(3-(/er/-butoxy)-3-oxopropyl)-4-fluorobenzoate [17a] as a pale-yellow color liquid.

Reference： [1]Patent: WO2019/200114,2019,A1 .Location in patent: Page/Page column 51-52

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P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere