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Product Details of [ 6526-79-0 ]

CAS No. :6526-79-0 MDL No. :MFCD08669637
Formula : C10H15N Boiling Point : -
Linear Structure Formula :- InChI Key :AHIOEYFAAFXSSZ-UHFFFAOYSA-N
M.W : 149.23 Pubchem ID :584050
Synonyms :

Safety of [ 6526-79-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340-P405-P501 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 6526-79-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6526-79-0 ]

[ 6526-79-0 ] Synthesis Path-Downstream   1~34

  • 1
  • [ 99-87-6 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
With aluminium trichloride; nitrogen trichloride; t-butyl bromide
With aluminium trichloride; nitrogen trichloride; t-butyl bromide In 1,2-dichloro-ethane
  • 2
  • [ 6526-79-0 ]
  • N,N-Dichlor-8-amino-p-cymol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; calcium hypochlorite In dichloromethane
  • 3
  • [ 6526-79-0 ]
  • [ 18344-79-1 ]
YieldReaction ConditionsOperation in experiment
With iodine pentafluoride
  • 4
  • [ 6526-79-0 ]
  • [ 4865-84-3 ]
  • 2-Benzo[d]isoxazol-3-yl-N-(1-methyl-1-p-tolyl-ethyl)-acetamide [ No CAS ]
  • 5
  • 1-(1-Isocyanato-1-methyl-ethyl)-4-methyl-benzene [ No CAS ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride In water 70-80 deg C, 0.5 h; reflux, 0.5 h;
  • 6
  • [ 917-54-4 ]
  • [ 104-85-8 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
With cerium(III) chloride In tetrahydrofuran at -50℃; 1.) 1 h, 2.) 3 h; Yield given;
  • 7
  • [ 94616-84-9 ]
  • [ 619-55-6 ]
  • [ 6526-79-0 ]
  • [ 104-85-8 ]
YieldReaction ConditionsOperation in experiment
58% at -78 - 0℃; for 2h; 5.0 equival. MeCeCl2;
YieldReaction ConditionsOperation in experiment
Rk. m. IF5 --> p,p'-Dimethyl-azocumol;
Rk.mit 70percent Ca(OCl)2, -5grad -> N,N-Dichlor-8-amino-p-cymol;
Rk.mit Cl2 -> 2- oder 3-Chlor-8-amino-p-cymol;
YieldReaction ConditionsOperation in experiment
Stage #1: With trimethylsilylazide; boron trifluoride diethyl etherate In toluene at 20℃; for 0.25h; Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 2h; 32 Reference Example 2
2-(2-fluorophenyl)propane-2-amine
General procedure: To a toluene solution (6 mL) of 2-(2-fluorophenyl)propane-2-ol (925 mg) while stirring, trimethylsilyl azide (830 mg) and boron trifluoride-diethyl ether complex (1021 mg) were sequentially dropped, and stirred for 15 minutes at room temperature. After disappearance of starting materials was verified, a saturated aqueous solution of sodium hydrogen carbonate (50 mL) was added to the reaction solution, and the product was extracted with ethyl acetate (40 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was dissolved in THF (15 mL), the solution was gradually dropped into a THF suspension (15 mL) of lithium aluminium hydride (228 mg) at room temperature. After stirring for 2 hours, to the reaction solution, water (230 μL), a 2 mol/L sodium hydroxide aqueous solution (230 μL), and water (690 μL) were gradually and sequentially dropped to the reaction solution. After being filtered with Celite, the mixture was concentrated under reduced pressure. The obtained residue was purified with silica gel column chromatography (chloroform/methanol=92/8 to 85/15) to give 2-(2-fluorophenyl)propane-2-amine (410 mg) as an oil. 1H NMR (300 MHz, CDCl3) δ 1.55 (s, 6H), 6.99-7.12 (m, 2H), 7.18-7.27 (m, 1H), 7.41-7.46 (m, 1H)
  • 10
  • [ 1197-01-9 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) SOCl2; 2.) HCl gas, 3.) ZnCl2 / 1.) pyridine 2: 8N hydrochloric acid / H2O / 70-80 deg C, 0.5 h; reflux, 0.5 h
  • 11
  • [ 122-00-9 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: tetrahydrofuran 2: 1.) SOCl2; 2.) HCl gas, 3.) ZnCl2 / 1.) pyridine 3: 8N hydrochloric acid / H2O / 70-80 deg C, 0.5 h; reflux, 0.5 h
  • 12
  • [ 153002-83-6 ]
  • [ 6526-79-0 ]
  • N-[1-(4-methylphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17β-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% 11.a 11(a) 11(a) N-[1-(4-Methylphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17β-carboxamide Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(4-methylphenyl)-1-methylethylamine (prepared as described in Preparation 10h) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 88%. Infrared Absorption Spectrum (KBr), νmax cm-1: 3446, 2963, 2896, 2203, 1685, 1637, 1604, 1495, 1382, 1257, 810, 541.
  • 13
  • [ 99-75-2 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
34% 10.h 1-(4-Methylphenyl)-1-methylethylamine PREPARATION 10h 1-(4-Methylphenyl)-1-methylethylamine Following a procedure similar to that described in Preparation 10a, but using methyl 4-methylbenzoate as a starting material, in a relative amount similar to that used in that Preparation, the title compound was obtained in a yield of 34%. Nuclear Magnetic Resonance Spectrum (CDCl3), δ ppm: 1.48 (6H, singlet); 1.62 (2H, broad singlet); 2.33 (3H, singlet); 7.14 (2H, doublet, J=9 Hz); 7.39 (2H, doublet, J=9 Hz). Infrared Absorption Spectrum (liquid film), νmax cm-1: 2965, 1587, 1514, 1360, 1189, 1115, 1020, 817, 722, 552.
  • 14
  • [ 1000141-63-8 ]
  • [ 6526-79-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogen In ethanol
  • 15
  • [ 6526-79-0 ]
  • [ 1000141-66-1 ]
YieldReaction ConditionsOperation in experiment
With sulfuryl dichloride; triethylamine In dichloromethane at -78 - 20℃; for 23h;
  • 16
  • [ 1372890-82-8 ]
  • [ 6526-79-0 ]
  • [ 1357456-33-7 ]
  • C30H37ClN4OS [ No CAS ]
YieldReaction ConditionsOperation in experiment
With acetic acid In methanol; 1,2-dichloro-ethane at 20 - 55℃; optical yield given as %de; Representative experimental procedure (compound 9c) General procedure: (3S,4S)-4-[4-(1H-Benzimidazol-2-yl)piperazin-1-yl]carbonyl}-3-(thiophen-3-yl)cyclohexanone (30 mg, 0.07 mmol) was dissolved in a mixture of MeOH (367 μL) and DCE (367 μL), and 2-(4-methoxyphenyl)propan-2-amine (59.2 mg, 0.29 mmol) was added followed by MP-cyanoborohydride (159 mg, 0.367 mmol) and acetic acid (13.0 μL, 0.22 mmol) at rt. The reaction mixture was shaken overnight at 55 °C, cooled to rt, filtered and concentrated under vacuum. LC-MS indicated a 3:2 ratio of diastereomeric reductive amination products.
  • 19
  • [ 6526-79-0 ]
  • [ 1198222-98-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere 3: iodine / 1,2-dichloro-ethane / 3 h / 20 - 95 °C / Inert atmosphere
  • 20
  • [ 6526-79-0 ]
  • [ 1198222-99-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere 5: iodine / 1,2-dichloro-ethane / 3 h / 20 - 95 °C / Inert atmosphere
  • 21
  • [ 6526-79-0 ]
  • [ 1380335-71-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere 5: iodine / 1,2-dichloro-ethane / 3 h / 20 - 95 °C / Inert atmosphere
  • 22
  • [ 6526-79-0 ]
  • [ 1380335-72-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere 5: iodine / 1,2-dichloro-ethane / 3 h / 20 - 95 °C / Inert atmosphere
  • 23
  • [ 6526-79-0 ]
  • [ 1380335-82-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere
  • 24
  • [ 6526-79-0 ]
  • [ 1380335-81-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere
  • 25
  • [ 6526-79-0 ]
  • [ 1198226-02-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere
  • 26
  • [ 6526-79-0 ]
  • [ 1198222-97-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere 3: iodine / 1,2-dichloro-ethane / 3 h / 20 - 95 °C / Inert atmosphere
  • 27
  • [ 6526-79-0 ]
  • [ 1198225-97-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere
  • 28
  • [ 6526-79-0 ]
  • [ 1198225-98-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere
  • 29
  • [ 6526-79-0 ]
  • C16H19NO3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere
  • 30
  • [ 6526-79-0 ]
  • [ 1198226-00-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere
  • 31
  • [ 6526-79-0 ]
  • [ 1309653-73-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere
  • 32
  • [ 6526-79-0 ]
  • [ 1309653-72-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: methylamine / methanol / 0.33 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C / Inert atmosphere 4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere
  • 34
  • [ 99-87-6 ]
  • [ 6526-79-0 ]
  • [ 4395-73-7 ]
YieldReaction ConditionsOperation in experiment
With C5H11NO*CHF3O3S In ethanol; water at 10℃; for 12h; Inert atmosphere; Sealed tube; Enzymatic reaction; Overall yield = 35 percent;
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