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CAS No. :	66-97-7
Formula :	C₁₁H₆O₃
M.W :	186.16
SMILES Code :	O=C1C=CC2=C(O1)C=C(OC=C3)C3=C2
Synonyms :	Ficusin; Furocoumarin; 7H-Furo[3,2-g]chromen-7-one
MDL No. :	MFCD00010520
InChI Key :	ZCCUUQDIBDJBTK-UHFFFAOYSA-N
Pubchem ID :	6199

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Caco-2 cells	50 µM	2 hours	To investigate the effects of psoralen on the transport of anastrozole in the Caco-2 cell transwell model. Results showed that psoralen increased the absorption of anastrozole and decreased its efflux by inhibiting P-gp activity.	Pharm Biol. 2018 Dec;56(1):433-439
Rat skin	2.0% (w/v)	24 hours	Evaluate the permeability of psoralen through the skin, showing that the skin deposition of psoralen from the optimized ethosome formulation (ES2) was 6.56-fold higher than that from the tincture.	Int J Nanomedicine. 2014 Jan 23;9:669-78
RAW 264.7 macrophages	62.5, 125, 250 µM	24 hours	To evaluate the effect of psoralen derivatives on the viability of RAW 264.7 cells, showing no significant differences at concentrations up to 250 μM.	Int J Mol Sci. 2022 May 22;23(10):5813.
Rat chondrocytes	0.01, 0.1, 1, 10, 100 µM	24, 48, 72 hours	Psoralen increased chondrocyte viability in a dose- and time-dependent manner, promoting chondrocyte proliferation.	Int J Mol Med. 2017 Nov;40(5):1377-1384
SMMC7721 hepatoma cells	20–80 µM	24–72 hours	Psoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis.	Biol Res. 2019 Jul 5;52(1):34
Human synoviocytes	1-100 µM	3 days	PSO significantly reversed TNF-α induced up-regulation of MMP13 and ILs synoviocytes in a dose-dependent manner (1 to 20 µM).	Int J Biol Sci. 2019 Jan 1;15(1):229-238
Rat chondrocytes	1-100 µM	3 days	PSO (10 µM) activated cartilaginous specific ECM expression along with up-regulation of proliferative genes at transcriptional levels.	Int J Biol Sci. 2019 Jan 1;15(1):229-238
HepG2 hepatoma cells	10–80 µM	72 hours	Psoralen had little effect on HepG2 cell proliferation.	Biol Res. 2019 Jul 5;52(1):34
Rat liver microsomes	2 mM	30 minutes	To investigate the effects of psoralen on the metabolic stability of anastrozole in rat liver microsomes. Results showed that psoralen significantly decreased the intrinsic clearance rates of anastrozole.	Pharm Biol. 2018 Dec;56(1):433-439
Plasmid DNA	0.1-900 µM	30-90 minutes	To investigate the effect of psoralen combined with UVA light on plasmid DNA. Results showed that psoralen alone was not toxic, but when combined with UVA light, DNA single-strand breaks increased, leading to a reduction in supercoiled conformation.	Int J Mol Sci. 2022 Dec 3;23(23):15233
Rat chondrocytes	1 µM	48 hours	Psoralen promoted chondrocyte proliferation by activating the Wnt/β-catenin signaling pathway, upregulating the expression of Wnt-4, Frizzled-2, β-catenin, and cyclin D1, and downregulating GSK-3β expression.	Int J Mol Med. 2017 Nov;40(5):1377-1384
Human primary chondrocytes	12 μg/mL	5 days	To verify that psoralen inhibits chondrocyte inflammation via an estrogen-like effect. Results showed that psoralen promoted the expression of estrogen target genes CTSD, PGR, and TFF1 and decreased the expression of inflammation-related genes TNF-α, IL-1β, and IL-6.	Aging (Albany NY). 2022 Aug 24;14(16):6716-6726
L02 hepatocytes	10–80 µM	72 hours	10–40 μM psoralen had little effect on L02 cell proliferation, while 80 μM psoralen inhibited L02 cell proliferation.	Biol Res. 2019 Jul 5;52(1):34
HepG2.2.15 cells	126.4 µM (IC50)	8 days	Evaluate the inhibitory effect of psoralen on HBV replication, showing that psoralen inhibits HBV replication in a concentration-dependent manner.	Virol Sin. 2022 Apr;37(2):256-265
FaDu cells	0.1-900 µM	90 minutes	To investigate the effect of psoralen combined with UVA light on the survival of FaDu cells. Results showed that psoralen alone was not cytotoxic, but when combined with UVA light, cell damage increased depending on psoralen concentration and irradiation time.	Int J Mol Sci. 2022 Dec 3;23(23):15233

Human	Graft-versus-host disease (GVHD) patients	Extracorporeal photopheresis (ECP)	0.9 μM 8-MOP	10-15 minutes	To study the effect of ECP treatment on Akt phosphorylation in T-lymphocytes from GVHD patients, results showed significantly decreased Akt phosphorylation post-treatment.	J Biol Chem. 2016 Nov 18;291(47):24364-24376
SD rats	MIA-induced osteoarthritis model	Intra-articular injection	1 mg/kg	Daily for 1 week, and once every three days for another 1 week	Following six weeks of PSO treatments to articular cartilage osteoarthritis, compared to MIA-induced group, the appearance and physiological structure of articular cartilage was more integrated with greatly organized chondrocytes and abundant cartilage matrix.	Int J Biol Sci. 2019 Jan 1;15(1):229-238
New Zealand rabbits	OA animal model induced by anterior cruciate ligament transection (ACLT)	Joint cavity injection	1 mg/mL, 0.1 mL/kg	Once a week, total of 5 times	To verify the therapeutic effect of psoralen on rabbit OA. Results showed that the psoralen group had less cartilage tissue destruction, decreased OARSI scores, increased subchondral bone mineral density (BMD), trabecular thickness and number, and decreased trabecular separation.	Aging (Albany NY). 2022 Aug 24;14(16):6716-6726
Male Sprague Dawley rats	Rat skin model	Topical administration	2.0% (w/v)	Single dose, continued for 10 hours	Evaluate the release of psoralen from ethosomes in vivo using microdialysis, showing significantly higher drug concentration in the skin compared to the tincture.	Int J Nanomedicine. 2014 Jan 23;9:669-78
Male Sprague-Dawley rats	No specific model	Oral gavage	20 mg/kg/day	Once daily for 10 days	To investigate the effects of psoralen pretreatment on the pharmacokinetics of anastrozole in rats. Results showed that psoralen significantly increased the systemic exposure of anastrozole.	Pharm Biol. 2018 Dec;56(1):433-439

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CAS No.: 66-97-7

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CAS No.: 66-97-7

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed