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[ CAS No. 66-98-8 ]

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Chemical Structure| 66-98-8
Chemical Structure| 66-98-8
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Product Details of [ 66-98-8 ]

CAS No. :66-98-8 MDL No. :MFCD00016714
Formula : C14H10O2 Boiling Point : 391.7°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :210.23 g/mol Pubchem ID :6200
Synonyms :

Safety of [ 66-98-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 66-98-8 ]

  • Downstream synthetic route of [ 66-98-8 ]

[ 66-98-8 ] Synthesis Path-Downstream   1~25

  • 1
  • [ 1591-30-6 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
67% To A stirred solution of 2. 04 G (0. 01 mole) of 4, 4 - dicyanobiphenyl in 75 ML CH2Cl2 under N2 was added DIBAL (4. 36 g, 30 ML, 1 M SOLUTION in CYCLOHEXANE) in 10 min., after 15 min. stirring, it was heated at 45C for 45 min. The cooled reaction mixture (ice-bath) was decomposed with AQ. 2NH2S04 (50 ML) while stirring continued for 1HR, CH2CI2 LAYER was separated, washed with water, NAHCOS, water and dried over NA2S04 anhd., filtered and cone. in vac., triturated with hexane and filtered and dried to yield 1. 4 G (67%) pale crystalline solid, M. P. 165-8C ; H-NMR (DMSO-D6) : 10. 07 (S, 2H), 7. 99 (D, 4H, J=8. 4HZ), 7. 92 (D, 4H, J=8. 4HZ) ; 13CNMR (DMSO-D6) : 192. 4, 144. 2, 135. 7, 129. 9, 127. 7 ; MS : m/e 210(M+).
  • 2
  • [ 66-98-8 ]
  • [ 50325-49-0 ]
  • (4-Vinyl-benzyl)-[1-(4'-[(E)-4-vinyl-benzylimino]-methyl}-biphenyl-4-yl)-meth-(Z)-ylidene]-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
In chloroform
  • 3
  • [ 2403-54-5 ]
  • [ 106-41-2 ]
  • [ 92-88-6 ]
  • [ 66-98-8 ]
  • [ 100980-82-3 ]
  • 4
  • [ 20248-86-6 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
50% With sodium hydrogencarbonate; dimethyl sulfoxide at 115℃; for 3.5h;
  • 8
  • [ 87199-17-5 ]
  • [ 1122-91-4 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
99% With potassium carbonate; In ethanol; water; at 50℃; for 19h; General procedure: To a round-bottom flask catalyst 1a (0.1 mol%, 1 mg), 4-formylphenyl boronic acid (1.13 mmol), 4-bromobenzaldehyde(1 mmol), K2CO3(1.2 mmol) and EtOH/H2O (5 mL, 1:1) were added.The reaction mixture was heated at 50C for 19 h. Then, the reac-tion mixture was cooled at room temperature, diluted with waterand extracted with dichloromethane. The organic phase is evapo-rated under reduced pressure and the residue purified with a short plug of silica under vacuum using petroleum ether/ethyl acetate aseluent.
84% With C23H23ClNO2PdTe; potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 15h;Catalytic behavior; General procedure: An oven-dried flask was charged with arylhalide (1.0mmol), phenylboronic acid (1.2mmol), K2CO3 (2.0mmol) and DMF/H2O (3.0 mL/1.0mL). A solution of catalyst 1 in DMF was then added via syringe. The flask was placed on an oil bath maintained at 100C under aerobic conditions and the reaction mixture stirred until maximum conversion of aryl halide to product occurred. The reaction was cooled and the reaction mixture poured to 50mL of water. The resulting mixture was extracted with diethylether (2×50mL). The organic layer was washed with water (2×50mL) and dried over anhydrous Na2SO4. The solvent of the extract was removed with rotary evaporator and the resulting residue purified by a column chromatography on silica gel using chloroform and hexane mixture (5:95% to 15:85%) as eluent.
81% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; water; for 12h;Inert atmosphere; Reflux; 4-Bromobenzaldehyde (100.0 mg, 0.54 mmol) and 4-formylphenylboronic acid (81.0 mg, 0.54 mmol) were dissolved in 10 mL of tetrahydrofuran. Aqueous solution of potassium carbonate (5.0 mL, 2.0 mol L-1) was added into the solution under nitrogen atmosphere. After the addition of bis(triphenylphosphine)palladium(II) dichloride (30.0 mg), the mixture was refluxed for 12 h. After cooled to room temperature, the mixture was extracted twice with dichloromethane (3 × 100 mL). The obtained organic layer was collected and dried with anhydrous sodium sulfate for 2 hours. After that, the solvent was removed at reduced pressure. The residue was chromatographed on a silica gel column to give green solid M2 with 81% yield. 1H NMR (400 MHz, CDCl3): delta(ppm) 10.05 (s, 3H, -CHO), 7.96 (d, J = 8.0 Hz, 6H, Ar-H), 7.77 (d, J = 8.0 Hz, 6H, Ar-H), 7.62 (d, J= 8.0 Hz, 6H, Ar-H), 7.29 (d, J = 8.0 Hz, 6H, Ar-H); IR (KBr, cm-1): 3032, 2830, 2732, 1701, 1590, 1525, 1499, 1285, 1180, 824, 714, 649, 571.
76.8% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; toluene; at 90℃;Inert atmosphere; A.The compound was treated with p-bromobenzaldehyde (100 mg, 0.54 mmol)4-formylphenylboronic acid (121.56 mg, 0.81 mmol),Bis (triphenylphosphine) palladium dichloride Pd (PPh3) 2Cl2 (18.97 mg, 0.03 mmol)Was dissolved in 20 mL of a mixed solvent of toluene and tetrahydrofuran (VToluene: VTHF = 1: 1)The reaction was refluxed at 90 C under nitrogen,Thin layer chromatography to the reaction is complete.After the resulting solution was spin off the organic solvent,Extracted with ethyl acetate,Organic layer washed three times,Saturated NaCl solution once,Dried over anhydrous sodium sulfate,The solvent is evaporated under reduced pressure;The crude product was passed through a column of petroleum ether and ethyl acetate mixed solvent (10: 1)Get 4,4'-biphenyldialdehyde(White needle-like solid, 161.6 mg, yield 76.8%).
71% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; for 6h;Reflux; General procedure: To a stirred solution of the corresponding commercially available formylphenyl boronic acid (1 equiv.) and bromobenzaldehyde (1 equiv.) in 1,2-dimethoxyethane (10mL/mmol) were added Pd(PPh3)4 (0.1 equiv.) and a solution of K2CO3 (6 equiv.) in water (1mL/mmol). The reaction mixture was refluxed for 6h and then concentrated under reduced pressure. The crude product was purified by column chromatography. 4.1.4.1 [1,1?-Biphenyl]-4,4?-dicarboxaldehyde (18a) (0037) The crude product was prepared according to procedure B starting from 4-bromobenzaldehyde (370mg, 2.00mmol) and 4-formylphenylboronic acid (300mg, 2.00mmol). After purification by column chromatography on silica gel (toluene/EtOAc 100:0 to 92:8), the pure product (300mg, 1.42mmol, 71%) was obtained as a white powder. m.p. 144-146C, lit. 146C [38]; 1H NMR (400MHz, CDCl3) delta ppm 7.86 (d, J=8.5Hz, 4H), 8.06 (d, J=8.5Hz, 4H), 10.14 (s, 2H); 13C NMR (100MHz, CDCl3) delta ppm 128.2 (4×CH), 130.6 (4×CH), 136.2 (2×C), 145.7 (2×C), 191.9 (2×CH).
With potassium hydroxide; In water; isopropyl alcohol; at 80℃; for 6h;Schlenk technique; Green chemistry; General procedure: Suzuki-Miyaura reactions were performed in a Schlenk tube. Weighed amounts of the solid reactants: phenylboronic acids (1.1 mmol), base (2. mmol), catalyst (20.00 mg), aryl bromide (1 mmol), and 5 mL of the solvent (2-propanol/water mixture) were introduced to the Schlenk tube. Next, the Schlenk tube was sealed with a rubber septum and introduced into an oil bath pre-heated to 80C. The reaction mixture was magnetically stirred at a given temperature for 6 h and, after that time, left for several min-utes to cool down. Next, the organic products were separated by extraction with 10 mL of diethyl ether. The extracts (10 mL) were GC-FID analyzed with dodecane (0.050 mL) as an internal standard to determine the conversion of aryl bromide. The products of the reaction were determined by GC-MS.
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 130℃;Microwave irradiation; Sealed tube; General procedure: To a solution of a 3- or 4-bromobenzaldehyde in a mixture DMF/water (3:1; 14.8mL/mmol) were added boronic acid derivative (1.5 equiv.), Pd(PPh3)4 (5mol%), and K2CO3 (2 equiv.). The reaction mixture was heated under microwave irradiation (130C) until TLC showed complete conversion of the starting material (0.5-1h). After cooling, the mixture was extracted with dichloromethane. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered off, and concentrated under reduced pressure to afford the corresponding crude product 2. (0027) Compounds 2a-2p were synthesized following the procedure described above from the corresponding boronic acids.

  • 9
  • [ 792-74-5 ]
  • [ 66-98-8 ]
  • 11
  • [ 1667-12-5 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
99.9% With sodium bromate; acetic acid; In water; at 75℃;Product distribution / selectivity; In a 50 ml three-necked flask equipped with a magnetic stirrer, a reflux condenser and a thermometer, 4.28 g (20 mmols) of 4,4'-bishydroxymethylbiphenyl and 10 ml of (166 mmols) of acetic acid were charged, followed by heating to 75C. An aqueous solution prepared by dissolving 2.04 g (13.5 mmols) of sodium bromate in 10 ml of water was added dropwise, and then the mixture was stirred at 75C until a color of bromine disappears. To the system, 50 ml of water was added and, after filtration, the resulting substance was dried to obtain 4.25 g of 4,4'-bisformylbiphenyl as a white crystal. Yield: 99.9%. It was confirmed by GS-MS that a molecular ion peak is 209.
  • 12
  • [ 66-98-8 ]
  • [ 24812-90-6 ]
  • bis-methyl 3-[(1Z)-1,1'-biphenyl-4-ylmethylene]amino}-4-methoxybenzoate [ No CAS ]
  • 13
  • [ 15164-44-0 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
92% With indium; palladium 10% on activated carbon; tetrabutylammomium bromide; lithium chloride In water at 90℃; for 24h; Green chemistry;
91% With 1-butyl-3-methylpyridinium bis[(trifluoromethyl)sulfonyl]amide In water for 0.5h; Microwave irradiation; Green chemistry;
89% With palladium diacetate In ethanol at 80℃; for 4h; Green chemistry; chemoselective reaction;
89% With palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Bi(het)aryls 2a-y; General Procedure General procedure: The appropriate (het)aryl halide 1 (0.5 mmol) was added to amixture of Pd(OAc)2 (0.05 mmol, 10 mol%), sensory component(8 mg), and K2CO3 (1.0 mmol, 2 equiv) in DMF (10 mL), and themixture was stirred and heated in an oil bath at 100 °C for 24 h.The mixture was then extracted with EtOAc (3 × 20 mL). Thecombined organic phases were dried (MgSO4), filtered, concentratedunder reduced pressure, and purified by column chromatography(silica gel).
59% With dipotassium hydrogenphosphate; digold(I)bis(diphenylphosphinomethane)dichloride; triethylamine In methanol; acetonitrile for 16h; Inert atmosphere; UV-irradiation;
53% With tetrabutylammomium bromide; potassium carbonate In water at 90℃; for 20h;
Multi-step reaction with 3 steps 1: alcohol 2: copper / 260 °C 3: alcohol; concentrated hydrochloric acid
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 48h;

  • 14
  • [ 613-33-2 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
85% With sodium persulfate; copper diacetate; iron(II) sulfate; dimethyl sulfoxide; In water; acetonitrile; at 70℃; for 4.16667h; In einem mit Argon begasten 100 ml Reaktor wurden 1.82 g 4, 4'-Dimethyl-biphenyl (CAS Reg. Nr. 613-33-2) [10 mmol] in 39.2 ml Acetonitril unter Zusatz von 0.8 ml Dimethylsulfoxid [11. 2 mmol] bei 70C geloest. Zur Loesung wurden 60 mg Cu (OAc) 2und 50 mg FESO4-7 H20und 10 ml Wasser beigefuegt. 11.8 g NA2S208 geloest in 30 ml Wasser wurden anschliessend unter heftigem Ruehren zugetropft. Nach 250 Minuten ist die Reaktion beendet. Die organische Phase wird mit Ethylacetat erschoepfend extrahiert. Die Ausbeute des Dialdehyds Biphenyl-4, 4'-dicarbaldehyd (CAS Reg. Nr. 66-98-8) betraegt 85 MOL%.
69% Example 6; Preparation of Biphenyl-4,4'-dicarboaldehyde; 2.5 g(13.7 mmol) of the compound 1 and 6.1 g(34.3 mmol) of N-bromosuccinimide were added in CCl4 solvent and refluxed for 24 hours. The reactant was cooled down and suction-filtrated. The filtrate was washed with distilled water and dried with anhydrous magnesium sulfate. The resulted product was dissolved again in chloroform together with 6.6 g(47.1 mmol) of hexamethylenetetraamine and the solution was refluxed for 5 hours. After the reactant was cooled down, the solvent was distilled off under reduced pressure and the residue was refluxed intensely in acetic acid/H2O(17 mL/17 mL) at 120 C. for 2 hours. Finally, 7 mL of HCl was added to be refluxed. After cooled down, the reactant was extracted with methylene chloride. The solution was distilled off under reduced pressure and the residue was purified through the column chromatography (silica gel, ethyl acetate/n-hexane=1:3) to be dried. Yield ; 69%. 1H-NMR(CDCl3): 10.1(s, 2H, -CHO), 7.99(d, 4H, Ar-H), 7.79(d, 4H, Ar-H).
  • 15
  • [ 3753-18-2 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
93.3 %Chromat. With sodium bromate; acetic acid at 90℃; for 1.5h; 11 In the same manner as in Example 3, the operation was conducted, except that 0.53 g (2 mmols) of bismethoxymethylbiphenyl was used in place of m-methoxybenzyl alcohol and also 0.2 g (1.35 mmols) of sodium bromate was used. With respect to the components in the reaction solution, 4,4'-bisformylbiphenyl was produced in an area ratio, as determined by gas chromatography, of 93.3% and 6.7% of bismethoxymethylbiphenyl as a raw material was remained. Example 3 (An embodiment of the invention described in the above embodiment [1]): Production of m-methoxybenzaldehyde In a 15 ml test tube type reaction vessel equipped with a magnetic stirrer and a reflux condenser, 0.55 g (4 mmols) of m-methoxybenzyl alcohol, 0.18 g (1.2 mmols) of sodium bromate and 2 ml (34.8 mmols) of acetic acid were charged, and then the resultant mixture was stirred at 90°C for 1.5 hours. Along with the progress of the reaction, a small amount of bromine was produced. After the completion of the reaction, bromine completely disappeared.
  • 16
  • 4,41-biphenyldicarboxylic acid [ No CAS ]
  • [ 1667-12-5 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
Synthesis of Schiff Base (CH=N) derivatives of Chrysamine G 4,41-biphenyldicarboxylic acid (Aldrich) is converted by reduction with LiAlH4 to <strong>[1667-12-5]4,4'-bis(hydroxymethyl)biphenyl</strong>, which, in turn, is converted to 4,4'-biphenyldicarboxaldehyde by treatment with BaMnO4 in ethyl acetate.
  • 17
  • [ 66-98-8 ]
  • [ 5872-08-2 ]
  • C34H36O8S2(2-)*2Na(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 10-camphorsufonic acid With sodium methylate In methanol; toluene at 25 - 66℃; Stage #2: 4,4'-diformylbiphenyl In methanol; toluene at 66 - 70℃; for 7h; 1 EXAMPLE 1 23.3 g (+-) of camphor-10-sulfonic acid are dissolved in 100 ml of toluene and 5 ml of methanol at 25° C. and are then charged with 11.2 g of sodium methylate and the mixture is heated, with stirring, to 66° C. A circa 50° C. warm solution consisting of 10.5 g of 1,1'-diphenyl-4,4'-bisaldehyde in 145 ml of toluene and 16 ml of methanol is then added to the above mixture over 2 hours at 66 to 70° C. This temperature is maintained for another 5 hours until no further increase of the product is found in a DC. Toluene and methanol are then distilled off as an azeotrope while being charged successively with a total of 115 ml of water. A solution forms at 98° C. which is clarified by filtration using some carbon. At about 50° C., 300 ml of methanol are added dropwise and the mixture is cooled to 10° C., the compound crystallising out as a sodium salt. After 2 hours, the precipitate is subjected to filtration and washed with 100 ml of methanol. Drying yields 16.8 g of crude product of the compound of formula (101). To purify the crude product, it is dissolved in 150 ml of methanol and 200 ml of water at 50° C. and clarified by filtration. For crystallisation, 200 ml of brine 15% and 100 ml of methanol are added and the mixture is cooled to 10° C. After 2 hours, the precipitate is collected by filtration, washed with 20 ml of methanol/water 1:1 and dried. A first fraction is obtained which consists of 5.8 g of the pure compound of formula (101). Additional fractions can be obtained from the filtrate.
  • 18
  • potassium 4-formylphenyltrifluoroborate [ No CAS ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
80% With palladium diacetate; potassium carbonate; In water; at 25℃; for 48h; General procedure: In a flask, at room temperature and under aerobic conditions, was added the appropriate potassium aryltrifluoroborate 2a-o (0.25 mmol), palladium (II) acetate (5 mol%, 3 mg) and potassium carbonate (0.40 mmol, 55 mg) followed by water (4.0 mL). The contents were stirred for 48h. After this period, the reaction was extracted with ethyl acetate (3 x 10 mL). The combined organic layer were washed with brine (2 x 20 mL), dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure to yield the desired biaryl compounds sufficiently pure for characterization.
  • 19
  • [ 195062-62-5 ]
  • [ 66-98-8 ]
  • 20
  • [ 1310479-47-0 ]
  • [ 66-98-8 ]
  • 4,4'-bis(2-((cyclopentylidenemethyl)thio)ethenyl)biphenyl [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% General procedure: NaOMe (4 mmol) was added to a stirred solution of the corresponding (diphenylphosphinoyl) methyl ethenyl sulfide (1, 2.2 mmol) in THF (20 mL) at room temperature. After 20 min, the system was treated with [1,1?-biphenyl]-4,4?-dicarbaldehyde (4, 1 mmol) and the solution was stirred under reflux for 3-5 h. A saturated aqueous solution of NH4Cl (20 mL) was added and the mixture was extracted with EtOAc (2× 20 mL). The combined organic layers were dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography, eluting with hexanes.
  • 21
  • [ 1310479-51-6 ]
  • [ 66-98-8 ]
  • 4,4'-bis(2-((2,2-diphenylethenyl)thio)ethenyl)biphenyl [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% General procedure: NaOMe (4 mmol) was added to a stirred solution of the corresponding (diphenylphosphinoyl) methyl ethenyl sulfide (1, 2.2 mmol) in THF (20 mL) at room temperature. After 20 min, the system was treated with [1,1?-biphenyl]-4,4?-dicarbaldehyde (4, 1 mmol) and the solution was stirred under reflux for 3-5 h. A saturated aqueous solution of NH4Cl (20 mL) was added and the mixture was extracted with EtOAc (2× 20 mL). The combined organic layers were dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography, eluting with hexanes.
  • 22
  • [ 4318-37-0 ]
  • [ 66-98-8 ]
  • 4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In dichloromethane; may be prepared by treating a mixture of 4,4'-biphenyldialdehyde and 1- methylhomopiperazine with sodium triacetoxyborohydride in DCM. The mixture was diluted with aqueous sodium bicarbonate and extracted with DCM. After removal of volatiles the product may be purified by thin layer chromatography
  • 23
  • [ 954502-30-8 ]
  • [ 66-98-8 ]
  • C32H48N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
40% General procedure: According to GP, aminopyran 5 (200 mg, 0.97 mmol) was dissolved in MeOH (17 mL), and 4,4'-biphenyldicarbaldehyde 16(97 mg, 0.46 mmol) was added followed by MgSO4 (285 mg, 2.37 mmol). The reaction mixture was stirred for 2.5 h. After filtration and cooling to 0 C, NaBH4 (38 mg, 1.01 mmol) was added. After stirring at r.t. for 2 h, the reaction was quenched with H2O (20 mL) and extracted with CH2Cl2 (3 x 20 mL), washed with brine, dried and concentrated. The crude product was purified by flash column chromatography (silica gel, CH2Cl2/MeOH 9:1 to 4:1) affording 20(103 mg, 40%) as a colorless solid.
  • 24
  • [ 15164-44-0 ]
  • [ 3956-07-8 ]
  • [ 66-98-8 ]
YieldReaction ConditionsOperation in experiment
18%; 51% With hydroxylamine hydrochloride; potassium carbonate; In dimethyl sulfoxide; at 120℃; for 48h;Green chemistry; General procedure: In a typical method, benzaldehyde (1.0 mmol), hydroxylaminehydrochloride (1.5 mmol), potassium carbonate (2.5 mmol) and0.5 mL of as-prepared SEF127-Pd(nanoparticle)/GO in DMSO were added to reaction media in the presence of 1.5 mL DMSO. The reac-tion was allowed to stir at 120C. Upon reaction completion, thecatalyst was separated by centrifuge and the organic residue was extracted with dichloromethane and evaporated under reducedpressure. The organic residue was purified by column chromatography. All yields were reported based on isolated amount. All productsare known and identified by 1H-NMR,13C-NMR spectrum and physical properties.
  • 25
  • [ 15862-94-9 ]
  • [ 66-98-8 ]
  • 4'-(2-(4,5-dimethoxy-2-nitrophenyl)-1-hydroxyethyl)[1,1'-biphenyl]-4-carbaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% General procedure: To a glass vessel capable of being sealed with Teflon cap (for microwave vials) were added 1 and benzaldehyde derivative (3 equiv.). The vessel was capped and then, evacuated and backfilled with N2 (process repeated 3X). Anhydrous DMF (3.5mL/mmol) was introduced and the solution was vigorously stirred for 20min at-20C. TDAE was added slowly and the mixture was stirred for 1h. Then, the reaction was stirred at room temperature overnight. After LC-MS analysis clearly showed that the chloride had been totally consumed, the reaction was hydrolysed with distilled water. The mixture was then extracted with dichloromethane. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered off and concentrated under reduced pressure to afford the corresponding crude product 3.
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