Alternatived Products of [ 66410-36-4 ]
Product Details of [ 66410-36-4 ]
CAS No. : | 66410-36-4 |
MDL No. : | MFCD09042610 |
Formula : |
C9H7ClO6S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
278.67
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 66410-36-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 66410-36-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 66410-36-4 ]
- 1
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[ 4442-53-9 ]
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[ 66410-36-4 ]
Yield | Reaction Conditions | Operation in experiment |
93.5% |
With chlorosulfonic acid; |
7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid 670 g of chlorosulfonic acid were introduced into a balloon flask provided with a condenser and a thermometer. 173 g of 1,4-benzodioxane-5-carboxylic acid were added in portions with the temperature being maintained at 5°-10° C. The mixture was heated at 55° C. and then cooled and poured into ice. The precipitate was dried off, washed and dried again. 250 g of 7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 210°-215° C.; yield: 93.5percent). |
75% |
With chlorosulfonic acid; at 70℃; for 3h;Inert atmosphere; |
Synthesis of 7-(chlorosulfonyl)-2,3-dihydrobenzo[b] [l,4]dioxine-5-carboxylic acid (XIII):To a stirred solution of 2,3-dihydrobenzo[b][l,4]dioxine-5-carboxylic acid XII (0.5 g, 2.77 mmol) was added chlorosulphonic acid (1.2 ml, 16.6 mmol) at 0°C under nitrogen atmosphere and the resulting mixture was heated at 70°C for 3 h. After completion of reaction, the reaction mixture was cooled, quenched with ice and extracted with DCM. The organic layer was dried over Na2S04 and evaporated under reduced pressure to afford product XIII in 75percent yield. |
Reference:
[1]Patent: US4186135,1980,A
[2]Patent: WO2011/72174,2011,A1 .Location in patent: Page/Page column 144-145
[3]Angewandte Chemie - International Edition,2017,vol. 56,p. 248 - 253
Angew. Chem.,2017,vol. 129,p. 254 - 259,6