Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 67451-81-4 | MDL No. : | MFCD05841588 |
Formula : | C12H15NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LZLRLAYVCUNAEX-UHFFFAOYSA-N |
M.W : | 221.25 | Pubchem ID : | 7152692 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | at 50℃; for 16 h; | To a solution of methyl 3-(mo holinomethyl)benzoate (5.02 g, 21.0 mmol) in MeOH (100 mL) was added sodium hydroxide (21.0 mL, 42.0 mmol, 2 M). The mixture was heated at 50 °C for 16 h. The solvent was removed, residue was adjusted to pH=3 with 1M HC1, and the suspension was filtered. The solid was dissolved in ACN (15 mL) and concentrated to give 3-(morpholinomethyl)benzoic acid (4.6 g, 100percent) as a white solid used without further purification in the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41% | With sodium hydroxide In methanol; dichloromethane | EXAMPLE 14 3-Morpholin-4-yl-methyl-benzoic Acid Commercially available methyl 3-bromomethyl benzoate (5 g, 22 mmole) was dissolved in dichloromethane (20 mL) and morpholine (3.93 mL, 45 mmol) was added. The solution was allowed to stir for 12 h, and filtered. The solvent of the filtrate was removed under reduced pressure. The resulting crude ester was dissolved in methanol, and sodium hydroxide (4.6 mL of 5N solution) was added. The solution was stirred overnight at 40° C. for 12 h. The solvent was partially removed under reduced pressure. The crude was acidified, dichloromethane was added and the solution was cooled in ice. After one hour, it was filtered, to provide the title product (2.3 g, 41percent) as the white solid hydrochloride salt: 1H-NMR (DMSO-d6) δ13.1 (bs, 1H), 11.8 (bs, 1H), 8.14 (s, 1H), 7.92 (m, 2H), 7.65 (t, J=4 Hz, 1H), 4.39 (bs, 2H), 3.91(m, 4H), 3.12 (m, 4H). MS (EI-NEG):[M+]221; Anal.RP-HPLC: 99percent purity. |
[ 65101-82-8 ]
4-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 137605-80-2 ]
3-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 190660-95-8 ]
Methyl 3-(morpholinomethyl)benzoate
Similarity: 0.93
[ 68453-56-5 ]
Methyl 4-(morpholinomethyl)benzoate
Similarity: 0.93
[ 868543-19-5 ]
2-Morpholin-4-ylmethylbenzoic acid
Similarity: 0.91
[ 65101-82-8 ]
4-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 137605-80-2 ]
3-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 868543-19-5 ]
2-Morpholin-4-ylmethylbenzoic acid
Similarity: 0.91
[ 160816-43-3 ]
4-(Morpholine-4-carbonyl)benzoic acid
Similarity: 0.86
[ 143269-99-2 ]
4-Hydroxy-3-(morpholinomethyl)benzoic acid dihydrate
Similarity: 0.84
[ 868543-19-5 ]
2-Morpholin-4-ylmethylbenzoic acid
Similarity: 0.91
[ 135651-46-6 ]
Methyl 2-(morpholinomethyl)benzoate
Similarity: 0.86
[ 895519-97-8 ]
4-(4-Ethylpiperazin-1-ylmethyl)benzoic acid
Similarity: 0.78
[ 106261-48-7 ]
4-((4-Methylpiperazin-1-yl)methyl)benzoic acid
Similarity: 0.78
[ 65101-82-8 ]
4-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 137605-80-2 ]
3-(Morpholinomethyl)benzoic acid hydrochloride
Similarity: 0.98
[ 190660-95-8 ]
Methyl 3-(morpholinomethyl)benzoate
Similarity: 0.93
[ 68453-56-5 ]
Methyl 4-(morpholinomethyl)benzoate
Similarity: 0.93
[ 868543-19-5 ]
2-Morpholin-4-ylmethylbenzoic acid
Similarity: 0.91