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Chemical Structure| 676137-00-1 Chemical Structure| 676137-00-1

Structure of 676137-00-1

Chemical Structure| 676137-00-1

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Product Details of [ 676137-00-1 ]

CAS No. :676137-00-1
Formula : C11H11BrO2
M.W : 255.11
SMILES Code : O=C1C(Br)COC2=C1C=C(CC)C=C2

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Application In Synthesis of [ 676137-00-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 676137-00-1 ]

[ 676137-00-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 672904-14-2 ]
  • [ 676137-00-1 ]
YieldReaction ConditionsOperation in experiment
84% Pyridinium hydrobromide perbromide (743 mg, 2.32 mmol) was added to a solution of the chromonone (372 mg, 2.11 mmol) in dry methylene chloride (15 mL) and the reaction mixture was stirred at room temperature for 2 h. Water (15 mL) was added to the mixture and the layers were separated. The aqueous layer was further extracted with methylene chloride. The combined organics were dried (magnesium sulfate) and concentrated under reduced pressure. Purification by flash column chromatography (silica, gradient 20: 1, and 10: 1 hexanes/ethyl acetate) provided the bromo ketone (450 mg, 84%) as a slightly yellow oil :'H NMR (300 MHz, CDC13) o 7.77 (d, J=2. 2 Hz, 1 H), 7.39 (dd, J=8. 5,2. 2 Hz, 1 H), 6.97 (d, J=8. 5 Hz, 1 H), 4.68-4. 52 (m, 3H), 2.62 (q, J=7. 6 Hz, 2H), 1.22 (t, J=7. 6 Hz, 3H); ESI MS m/z 255 [C1 lCl 1 BrO2+H] +.
 

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