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Chemical Structure| 6840-28-4 Chemical Structure| 6840-28-4

Structure of 6840-28-4

Chemical Structure| 6840-28-4

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Product Details of [ 6840-28-4 ]

CAS No. :6840-28-4
Formula : C19H17OP
M.W : 292.31
SMILES Code : CC1=CC=C(P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C=C1

Safety of [ 6840-28-4 ]

Application In Synthesis of [ 6840-28-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6840-28-4 ]

[ 6840-28-4 ] Synthesis Path-Downstream   1~1

  • 1
  • C49H64N9O10P [ No CAS ]
  • [ 6840-28-4 ]
  • [ 69558-55-0 ]
YieldReaction ConditionsOperation in experiment
1.09 g With palladium on activated charcoal; hydrogen; In methanol; at 20℃; under 3620.13 Torr; for 24h; To 100 mg dry Pd/C in a hydrogenation bottle wasadded H-RKDVY-OBnDpp 10k in 150 mL methanol. The bottle was placed under 70 PSIH2 atmosphere and shaken at room temperature for 24 hours. The reaction mixture wasfiltered through celite, and evacuated to dryness. The crude was dissolved in a mixture of10% acetic acid (aq) and chloroform, after which the aqueous layer was washed X2 withchloroform. Evacuation of the aqueous layer afforded thymopentin as a white solid; yield,1.09 g, 87%; Retention time on analytical RP-HPLC with 50% MeCN in 0.06% TFAH20 asthe eluent: 1.24 mm, 98.9% purity; HRMS (ESI): m/z calcd for [C30H49N909 + H]:680.3731, found: 680.3730.o our delight, HPLC analysis of the product peptide reveals that the compound is nearly 99% pure without any column chromatography, recrystallization, or polymer supports. The GAP group can be recovered simply by evacuating the chloroformlayer after extraction. Subjecting this raw material to the synthesis methods in FIG. 2 can regenerate BndppOH.
 

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