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Chemical Structure| 68682-48-4 Chemical Structure| 68682-48-4

Structure of 68682-48-4

Chemical Structure| 68682-48-4

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Product Details of [ 68682-48-4 ]

CAS No. :68682-48-4
Formula : C12H16O2
M.W : 192.25
SMILES Code : CC(C1=CC=C(C)C=C1)(C)C(OC)=O
MDL No. :MFCD23096913

Safety of [ 68682-48-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 68682-48-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 68682-48-4 ]

[ 68682-48-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 20430-18-6 ]
  • [ 68682-48-4 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; In methanol; water; (3) Synthesis of Methyl 2-(4-Methylphenyl)-2-methylpropionate A solution of 2-(4-methylphenyl)-2-methylpropionic acid (60.0 g), sulfuric acid (0.6 ml) and methanol (300 ml) was refluxed for 19 hr. The solvent was evaporated, and water (200 ml) was added and the mixture was extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (61.52 g) as a pale-brown oil. 1H-NMR(CDCl3)δ:1.56(6H, s), 2.32(3H, s), 3.64(3H, s), 7.13(2H, d, J=8.6 Hz), 7.22(2H, d, J=8.6 Hz). MS(EI): 192(M+).
  • 2
  • [ 20430-18-6 ]
  • [ 74-88-4 ]
  • [ 68682-48-4 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In acetone; at 20 - 50℃; for 3h; To a stirred mixture of Intermediate 28 (4.86 g, 26.5 mmol) and K2C03 (14.6 g, 106 mmol) in acetone (150 mL), methyl iodine (ALDRICH, 16 mL, 265 mmol) was added at room temperature, and, then, the reaction mixture was stirred at 50C for 3 hours. The mixture was filtered, the filtrate was evaporated to dryness, and the residue was chromatographed (silica gel, 1:1 hexane/ethyl acetate) to obtain 4.37 g of the desired product. 1H NMR (300 MHz, DMSO-d6) S ppm: 7.15 (m, 4H), 3.56 (s, 3H), 2.25 (s, 3H), 1.46 (s, 6H).
 

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