Home Cart 0 Sign in  
X

[ CAS No. 6908-41-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 6908-41-4
Chemical Structure| 6908-41-4
Chemical Structure| 6908-41-4
Structure of 6908-41-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 6908-41-4 ]

Related Doc. of [ 6908-41-4 ]

Alternatived Products of [ 6908-41-4 ]

Product Details of [ 6908-41-4 ]

CAS No. :6908-41-4 MDL No. :MFCD00009984
Formula : C9H10O3 Boiling Point : -
Linear Structure Formula :- InChI Key :VBWFYEFYHJRJER-UHFFFAOYSA-N
M.W : 166.17 Pubchem ID :81325
Synonyms :

Safety of [ 6908-41-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 6908-41-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 6908-41-4 ]
  • Downstream synthetic route of [ 6908-41-4 ]

[ 6908-41-4 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 67-56-1 ]
  • [ 120-61-6 ]
  • [ 23405-32-5 ]
  • [ 6908-41-4 ]
  • [ 75164-88-4 ]
  • [ 1571-08-0 ]
Reference: [1] Chemistry Letters, 1980, p. 483 - 486
  • 2
  • [ 6908-41-4 ]
  • [ 34040-64-7 ]
Reference: [1] European Journal of Organic Chemistry, 2018, vol. 2018, # 33, p. 4541 - 4547
[2] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1964 - 1972
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 4, p. 583 - 591[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 4, p. 673 - 681
[5] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 11, p. 3434 - 3436
  • 3
  • [ 75-62-7 ]
  • [ 6908-41-4 ]
  • [ 34040-64-7 ]
Reference: [1] Synthesis, 2011, # 2, p. 342 - 346
  • 4
  • [ 6908-41-4 ]
  • [ 18469-52-8 ]
YieldReaction ConditionsOperation in experiment
92% With (carbonyl)chloro(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; [5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphane In tert-Amyl alcohol at 130℃; for 20 h; Inert atmosphere; Cooling Example 6Direct Single-Stage Amination of Alcohols andHydroxy Acids by Means of Ammonia Over aHomogeneous Ruthenium Catalyst and Xantphos ata high V7J Vgas (according to the invention)Under an argon atmosphere, m g of starting material, mRU g of [carbonylchlorohydridotris(triphenylphosphane)ruthenium(II)] and mp g of 9,9-dimethyl-4,5-bis (diphenylphosphino)xanthene as catalyst and V07 ml of 2-methyl-2-butanol as solvent were introduced into a 50 mlsteel tube. The vessel was closed, pressurized three times with 20 bar of argon and depressurized each time. The vessel was then cooled by means of dry ice and m g of ammonia were condensed in. The reactor is heated to T° C. and maintained at this temperature for 20 hours. Afier cooling to room temperature, the reactor was depressurized and opened, the solvent was removed on a rotary evaporator and the residue was dissolved in methanol and then analysed by gas chromatography. Reaction parameters and conversions and selectivities to the desired reaction product are shown in Tab. 5. The results show that many different hydroxy-thnctionalized substrates can be aminated by the method described.
Reference: [1] Patent: US2013/331580, 2013, A1, . Location in patent: Paragraph 0063
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 33, p. 7599 - 7603
  • 5
  • [ 6908-41-4 ]
  • [ 1227476-15-4 ]
  • [ 3814-10-6 ]
YieldReaction ConditionsOperation in experiment
38% With tert.-butylhydroperoxide; water In acetonitrile at 120℃; for 24 h; Sealed tube General procedure: The mixture of azobenzenes 1 (0.25 mmol), alcohols 2(0.5 mmol), TBHP (1 mmol) and CH3CN (1 mL) were added into a sealed tube under air. After being stirred vigorously at 120 °C for 24 h, the mixture was evaporated under vacuum. The corresponding product was isolated by silica gel column chromatography with a petroleum ether/ethyl acetate mixture as eluent.
Reference: [1] Tetrahedron, 2016, vol. 72, # 3, p. 436 - 441
  • 6
  • [ 6908-41-4 ]
  • [ 151-50-8 ]
  • [ 76469-88-0 ]
YieldReaction ConditionsOperation in experiment
86%
Stage #1: With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 15 h;
Stage #2: With 18-crown-6 ether In acetonitrile at 20℃; for 40 h;
Methyl 4-hydroxymethylbenzoate (1.00 g) was dissolved in dichloromethane (20 ml). After addition of triethylamine (0.9 ml) to the resulting solution, a dichloromethane solution (dichloromethane: 5 ml) of methanesulfonyl chloride (0.70 g) was added under ice cooling. After stirring at room temperature for 15 hours, the reaction mixture was diluted with dichloromethane, washed with water, and dried over anhydrous sodium sulfate. The residue obtained by distilling off the solvent was dissolved in acetonitrile (12 ml). Potassium cyanide (0.80 g) and 18-crown-6 (0.16 g) were added and the resulting mixture was stirred at room temperature for 40 hours. After concentration of the reaction mixture under reduced pressure, the residue was diluted with dichloromethane, washed with water and dried over anhydrous sodium sulfate. The residue obtained by distilling off the solvent under reduced pressure was purified by chromatography (dichloromethane) on a silica gel column, whereby colorless crystals (0.91 g, 86percent) were obtained. A portion of the crystals were recrystallized from a mixed solvent of hexane and ethyl acetate to yield colorless crystals.1H-NMR (CDCl3) δ: 3.82(2H,s), 3.93(3H,s), 7.42(2H,d,J=8.3Hz), 8.06(2H,d,J=8.3Hz).
Reference: [1] Patent: EP1577302, 2005, A1, . Location in patent: Page/Page column 117
  • 7
  • [ 6908-41-4 ]
  • [ 124-63-0 ]
  • [ 76469-88-0 ]
Reference: [1] Patent: US6525042, 2003, B1,
[2] Patent: EP1104754, 2001, A1,
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 6908-41-4 ]

Aryls

Chemical Structure| 74079-01-9

[ 74079-01-9 ]

Dimethyl terephthalate-2,3,5,6-d4

Similarity: 1.00

Chemical Structure| 67853-03-6

[ 67853-03-6 ]

Methyl 3-(hydroxymethyl)benzoate

Similarity: 1.00

Chemical Structure| 25081-39-4

[ 25081-39-4 ]

Methyl 3,5-dimethylbenzoate

Similarity: 1.00

Chemical Structure| 38588-64-6

[ 38588-64-6 ]

3,5-Bis(methoxycarbonyl)benzoic acid

Similarity: 1.00

Chemical Structure| 1877-71-0

[ 1877-71-0 ]

3-(Methoxycarbonyl)benzoic acid

Similarity: 1.00

Alcohols

Chemical Structure| 67853-03-6

[ 67853-03-6 ]

Methyl 3-(hydroxymethyl)benzoate

Similarity: 1.00

Chemical Structure| 109862-53-5

[ 109862-53-5 ]

Dimethyl 5-(hydroxymethyl)isophthalate

Similarity: 1.00

Esters

Chemical Structure| 74079-01-9

[ 74079-01-9 ]

Dimethyl terephthalate-2,3,5,6-d4

Similarity: 1.00

Chemical Structure| 67853-03-6

[ 67853-03-6 ]

Methyl 3-(hydroxymethyl)benzoate

Similarity: 1.00

Chemical Structure| 25081-39-4

[ 25081-39-4 ]

Methyl 3,5-dimethylbenzoate

Similarity: 1.00

Chemical Structure| 38588-64-6

[ 38588-64-6 ]

3,5-Bis(methoxycarbonyl)benzoic acid

Similarity: 1.00

Chemical Structure| 1877-71-0

[ 1877-71-0 ]

3-(Methoxycarbonyl)benzoic acid

Similarity: 1.00