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Chemical Structure| 693-57-2 Chemical Structure| 693-57-2
Chemical Structure| 693-57-2

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Product Details of 12-Aminododecanoic acid

CAS No. :693-57-2
Formula : C12H25NO2
M.W : 215.33
SMILES Code : O=C(O)CCCCCCCCCCCN
MDL No. :MFCD00008153
InChI Key :PBLZLIFKVPJDCO-UHFFFAOYSA-N
Pubchem ID :69661

Safety of 12-Aminododecanoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of 12-Aminododecanoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 693-57-2 ]

[ 693-57-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 693-57-2 ]
  • [ 67107-87-3 ]
YieldReaction ConditionsOperation in experiment
79% To a stirred suspension of l2-aminododecanoic acid (4.3 g, 20 mmol) in 20 mL MeOH at 0 C was added acetyl chloride (3.6 mL, 2.5 equiv) dropwise. The mixture was then refluxed for 3 h. The solvent was then distilled off under reduced pressure. The white solid obtained was used for the next step without further purification. 100 mL anhydrous THF was added, and then Lithium aluminum hydride (3.2 g, 84 mmol) was added portionwise at 0 C. The mixture was heated under reflux for 16 h. The mixture was cooled down to 0 C, and quenched by 10 mL ice water. 6 mL 15% NaOH(aq) solution was added, and the mixture was stirred at room temperature for 1 h. The gray L1AIH4 turned into off white precipitates and was filtered off, washed with CH2CI2 and MeOH. The filtrate was concentrated to give 12-amino- l-dodecanol (26b) as a white solid (3.18 g, 79%). This material was used for the next step reaction without further purification. 'H NMR (400 MHz, CDCh): d 3.64 (t, J= 6.6 Hz, 2H), 2.68 (t, J= 7.0 Hz, 2H), 1.56 (m, 2H), 1.44 (m, 2H), 1.40- 1.20 (m, 16H).
  • 2
  • [ 133081-26-2 ]
  • [ 693-57-2 ]
  • 12-(6-Boc-hydrazinopyridine-3-amido)dodecanoic acid [ No CAS ]
 

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