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Quality Control of [ 6935-29-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 6935-29-1 ]

SDS Specification

Alternatived Products of [ 6935-29-1 ]

Product Details of [ 6935-29-1 ]

CAS No. :	6935-29-1	MDL No. :	MFCD00054593
Formula :	C₈H₆N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	146.15	Pubchem ID :	-
Synonyms :

Safety of [ 6935-29-1 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 6935-29-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 6935-29-1 ]
Downstream synthetic route of [ 6935-29-1 ]

[ 6935-29-1 ] Synthesis Path-Upstream 1~8

1
[ 6935-29-1 ]
[ 1448-87-9 ]

Yield	Reaction Conditions	Operation in experiment
63%	With N,N-dimethyl-formamide; trichlorophosphate In dichloromethane at 0 - 25℃; Inert atmosphere	General procedure: The procedure is identical to general procedure I, except that reactions were conducted at 0.2 M concentration with N-oxide (1.00 equiv), POBr₃ (3.00 equiv), DMF (1.50 equiv) at rt. 4.2 General procedure I for the bromination of azine N-oxides (0013) To a stirred solution of the appropriate azine N-oxides in anhydrous CH₂Cl₂ (0.1 M) at 0 °C is added POBr₃ (1.2 equiv) followed by dropwise addition of DMF (0.5 equiv) under argon. The resulting reaction mixture was warmed to 25 °C and stirred for several hours until the reaction is complete as indicated by TLC. Saturated aqueous sodium carbonate solution is added to the reaction mixture slowly to adjust the pH to 7–8. The resulting mixture is separated and the aqueous phase is extracted with CH₂Cl₂ thoroughly. The organic phase is combined and washed with brine, dried over Na₂SO₄, filtered and concentrated under reduced pressure to afford the crude product, which is purified by flash column chromatography using PE/EA (100:1) as eluent.

Reference： [1] Tetrahedron, 2016, vol. 72, # 38, p. 5762 - 5768
[2] Journal of the Chemical Society, 1953, p. 2816,2819

2
[ 6935-29-1 ]
[ 91-19-0 ]
[ 1448-87-9 ]
[ 5448-43-1 ]
[ 7483-33-2 ]

Reference： [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804

3
[ 6935-29-1 ]
[ 1448-87-9 ]
[ 5448-43-1 ]
[ 62163-09-1 ]
[ 1196-57-2 ]

Reference： [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804

4
[ 6935-29-1 ]
[ 1448-87-9 ]
[ 5448-43-1 ]

Reference： [1] Bulletin des Societes Chimiques Belges, 1986, vol. 95, # 8, p. 663 - 670

5
[ 6935-29-1 ]
[ 7677-24-9 ]
[ 91-19-0 ]
[ 1448-87-9 ]
[ 23088-24-6 ]
[ 77130-32-6 ]
[ 1196-57-2 ]
[ 7483-33-2 ]

Reference： [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804

6
[ 6935-29-1 ]
[ 10025-87-3 ]
[ 1448-87-9 ]

Reference： [1] Journal of the Chemical Society, 1953, p. 2816,2819

7
[ 6935-29-1 ]
[ 1448-87-9 ]
[ 5448-43-1 ]
[ 62163-09-1 ]
[ 1196-57-2 ]

Reference： [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804

8
[ 6935-29-1 ]
[ 7677-24-9 ]
[ 5448-43-1 ]
[ 62163-09-1 ]
[ 1196-57-2 ]
[ 7483-33-2 ]

Reference： [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804

[ 6935-29-1 ] Synthesis Path-Downstream 1~21

1
[ 91-19-0 ]
[ 6935-29-1 ]

Yield	Reaction Conditions	Operation in experiment
80%	With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0℃; for 16h;Inert atmosphere;	Quinoxaline (295 mg, 1.71 mmol) was added in a two-necked flask (10 mL) equipped with a stirring bar. Under nitrogen atmosphere, dry and degas CH2Cl2 (3 mL) was added. At 0C, a solution of m-chloroperbenzoic acid (150 mg, 1.15 mmol in 3 mL of CH2Cl2) was added dropwise at the reaction mixture. After 16 hours, NaHCO3 solution was added and extracted with CH2Cl2 (3 x 10 mL). The organic phase was dried with MgSO4 and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate/methanol 8:1) to obtain white crystals (199 mg, 80%), m.p.: 122 - 123C, 1H NMR (300 MHz, CDCl3) delta = 8.68 (d, J = 3.5 Hz, 1H), 8.59 (dd, J = 8.5, 1.3 Hz, 1H), 8.36 (d, J = 3.5 Hz, 1H), 8.14 (dd, J = 8.3, 1.0 Hz, 1H), 7.84 (ddd, J = 8.4, 7.0, 1.6 Hz, 1H), 7.76 (ddd, J = 8.4, 7.0, 1.4 Hz, 1H). 13C NMR (101 MHz, CDCl3) delta = 145.4, 145.3, 137.8, 132.2, 130.6, 129.7, 129.6, 119.1.
	With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 40℃; for 0.25 - 6h;	Formation of Quinoline-N-oxides: The appropriate quinoline (10 mmol) may be dissolved in CH2Cl2 and treated with solid NaHCO3 (50 mmol) followed by m-CPBA (10.0 mmol). The reaction may be stirred at between 0-40C for between 15 minutes to 6 hours. In one variation, the reaction is stirred at about 23 C for 4 hours. The mixture may then be transferred to a separatory funnel and washed with water, saturated aqueous NaHCO3 and brine, and then dried (MgS04) and concentrated in vacuo. The resulting crude solid is often pure enough to carry forward to the next reaction.

Reference： [1]Organic and Biomolecular Chemistry,2014,vol. 12,p. 3026 - 3036
[2]Tetrahedron Letters,2018,vol. 59,p. 2562 - 2566
[3]Angewandte Chemie - International Edition,2006,vol. 45,p. 7781 - 7786
[4]Advanced Synthesis and Catalysis,2019,vol. 361,p. 2456 - 2465
[5]Journal of the American Chemical Society,2017,vol. 139,p. 5998 - 6007
[6]Angewandte Chemie - International Edition,2016,vol. 55,p. 12891 - 12894
Angew. Chem.,2016,vol. 128,p. 13083 - 13086,4
[7]Synthesis,1997,p. 1387 - 1388
[8]Advanced Synthesis and Catalysis,2019,vol. 361,p. 725 - 738
[9]Journal of the Chemical Society,1953,p. 2816,2819
[10]Patent: WO2005/61519,2005,A1 .Location in patent: Page/Page column 84
[11]Organic Letters,2013,vol. 15,p. 5198 - 5201
[12]Organic and Biomolecular Chemistry,2015,vol. 13,p. 3207 - 3210
[13]Organic Letters,2015,vol. 17,p. 3134 - 3137
[14]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[15]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[16]Organic and Biomolecular Chemistry,2017,vol. 15,p. 3165 - 3169
[17]Journal of Organic Chemistry,2020,vol. 85,p. 2476 - 2485
[18]Synthesis,2020,vol. 52,p. 219 - 226

2
[ 6935-29-1 ]
[ 1448-87-9 ]

Yield	Reaction Conditions	Operation in experiment
63%	With N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; at 0 - 25℃;Inert atmosphere;	General procedure: The procedure is identical to general procedure I, except that reactions were conducted at 0.2 M concentration with N-oxide (1.00 equiv), POBr3 (3.00 equiv), DMF (1.50 equiv) at rt. 4.2 General procedure I for the bromination of azine N-oxides (0013) To a stirred solution of the appropriate azine N-oxides in anhydrous CH2Cl2 (0.1 M) at 0 C is added POBr3 (1.2 equiv) followed by dropwise addition of DMF (0.5 equiv) under argon. The resulting reaction mixture was warmed to 25 C and stirred for several hours until the reaction is complete as indicated by TLC. Saturated aqueous sodium carbonate solution is added to the reaction mixture slowly to adjust the pH to 7-8. The resulting mixture is separated and the aqueous phase is extracted with CH2Cl2 thoroughly. The organic phase is combined and washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to afford the crude product, which is purified by flash column chromatography using PE/EA (100:1) as eluent.

Reference： [1]Tetrahedron,2016,vol. 72,p. 5762 - 5768
[2]Journal of the Chemical Society,1953,p. 2816,2819

3
[ 613-90-1 ]
[ 6935-29-1 ]
[ 91-19-0 ]
[ 23088-24-6 ]
[ 7483-33-2 ]

Yield	Reaction Conditions	Operation in experiment
	In xylene for 2h; Heating; Yield given. Yields of byproduct given;

Reference： [1]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]

4
[ 6935-29-1 ]
[ 7677-24-9 ]
[ 91-19-0 ]
[ 1448-87-9 ]
[ 23088-24-6 ]
[ 77130-32-6 ]
[ 1196-57-2 ]
[ 7483-33-2 ]

Yield	Reaction Conditions	Operation in experiment
	With benzoyl chloride In dichloromethane for 3h; Ambient temperature; different cyanides, reagents, catalyst, solvents, reaction times and temperatures;

Reference： [1]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]

5
[ 6935-29-1 ]
[ 7677-24-9 ]
[ 5448-43-1 ]
[ 62163-09-1 ]
[ 1196-57-2 ]
[ 7483-33-2 ]

Reference： [1]Tetrahedron,1989,vol. 45,p. 7795 - 7804

6
[ 6935-29-1 ]
[ 151-50-8 ]
[ 91-19-0 ]
[ 5448-43-1 ]
[ 23088-24-6 ]
[ 7483-33-2 ]

Yield	Reaction Conditions	Operation in experiment
	With benzoyl chloride In chloroform; water for 16h; Ambient temperature; Yield given. Further byproducts given. Yields of byproduct given;

Reference： [1]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]

7
[ 6935-29-1 ]
[ 91-19-0 ]
[ 1448-87-9 ]
[ 5448-43-1 ]
[ 7483-33-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium cyanide; benzoyl chloride In chloroform; water for 0.5h; Ambient temperature; Yield given. Further byproducts given. Yields of byproduct given;

Reference： [1]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]

8
[ 6935-29-1 ]
[ 1448-87-9 ]
[ 5448-43-1 ]

Yield	Reaction Conditions	Operation in experiment
1: 10 % Chromat. 2: 90 % Chromat.	With trichlorophosphate for 0.166667h; Heating;

Reference： [1]Nasielski-Hinkens, R.; Vyver, E. Vande; Nasielski, J. [Bulletin des Societes Chimiques Belges, 1986, vol. 95, # 8, p. 663 - 670]

9
[ 6935-29-1 ]
[ 1448-87-9 ]
[ 5448-43-1 ]
[ 62163-09-1 ]
[ 1196-57-2 ]

Reference： [1]Tetrahedron,1989,vol. 45,p. 7795 - 7804

10
[ 6935-29-1 ]
[ 2845-89-8 ]
2-(3-methoxyphenyl)quinoxaline 1-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
57%	With potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate In 1,4-dioxane at 110℃;

Reference： [1]Leclerc, Jean-Philippe; Fagnou, Keith [Angewandte Chemie - International Edition, 2006, vol. 45, # 46, p. 7781 - 7786]

11
[ 6935-29-1 ]
[ 23088-24-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: benzoyl chloride, KCN / CHCl₃; H₂O / 0.5 h / Ambient temperature 2: various solvent(s) / 7 h / Heating
	Multi-step reaction with 2 steps 1: benzoyl chloride, water, KCN / methanol / 2 h / Ambient temperature 2: various solvent(s) / 7 h / Heating

Reference： [1]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]
[2]Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. [Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804]

12
[ 6935-29-1 ]
[ 40899-68-1 ]
2-(1-(methoxymethyl)-1H-indol-3-yl)quinoxaline 1-oxide [ No CAS ]

Reference： [1]Chemistry Letters,2011,vol. 40,p. 555 - 557

13
[ 273-53-0 ]
[ 6935-29-1 ]
[ 24613-98-7 ]

Yield	Reaction Conditions	Operation in experiment
24%	With lithium tert-butoxide In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h;

Reference： [1]Chen, Xiaopei; Cui, Xiuling; Yang, Fangfang; Wu, Yangjie [Organic Letters, 2015, vol. 17, # 6, p. 1445 - 1448]

14
[ 554-14-3 ]
[ 6935-29-1 ]
C₁₃H₁₀N₂OS [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxygen; copper(II) acetate monohydrate In 1,4-dioxane at 140℃; for 30h; Schlenk technique; Green chemistry;	General procedure for the oxidative C-H/C-Hcross-coupling of thiophenes and furans with Nheteroarenesusing O2 as the terminal oxidant General procedure: A flame-dried Schlenk test tube with a magnetic stirring bar was charged with Pd(dppf)Cl2 (0.0125 mmol, 2.5 mol%), Cu(OAc)2*H2O (0.1 mmol, 0.2 equiv.), N-heteroarene (1,0.5 mmol), pyridine (0.5 mmol, 1.0 equiv.) and 1,4-dioxane (1.0 mL). After the reaction mixture was stirred for 10 min at room temperature, thiophene, furan or indole (2, 1.5mmol, 3.0 equiv.) was added. The resulting mixture was heated at 140 °C for 30 h under 1 atm of oxygen, and then cooled to ambient temperature. The mixture was diluted with 30 mL of CH2Cl2, filtered through a celite pad, and then washed with 10-20 mL of CH2Cl2. The combined organic extracts were concentrated and the resulting residue was purified by column chromatography on silica gel to provide the desired product.

Reference： [1]Shi, Yang; Wang, Zhen; Cheng, Yangyang; Lan, Jingbo; She, Zhijie; You, Jingsong [Science China Chemistry, 2015, vol. 58, # 8, p. 1292 - 1296]

15
[ 6935-29-1 ]
[ 34392-85-3 ]
2-(2-chloro-6-methoxypyridin-3-yl)quinoxaline N-oxide [ No CAS ]

Reference： [1]Organic Process Research and Development,2016,vol. 20,p. 1283 - 1296

16
[ 6935-29-1 ]
[ 36856-91-4 ]

Yield	Reaction Conditions	Operation in experiment
99%	With triethylamine; phosphorus(V) oxybromide; In dichloromethane; at 20℃;Inert atmosphere;	General procedure: A solution of POBr3 (1.67g, 5.8mmol) in methylene chloride (200mL) was added dropwise to a magnetically stirred solution of quinoxaline-N-oxide (325mg gr, 2.0mmol) 26 in mixture of methylene chloride (10mL) and triethylamine (510mg, 5.0mmol). The resulting mixture was stirred for 30minat room temperature and 1h at 40C. The mixture was diluted with solution of sodium hydroxide (10%, 10mL) and the aqueous solution was extracted with methylene chloride (2×50mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The residue was purified via column chromatography on silica gel (50g) by eluting with 10% EtOAc/n-hexane.
85%	With N,N-dimethyl-formamide; phosphorus(V) oxybromide; In dichloromethane; at 0 - 25℃;Inert atmosphere;	General procedure: The procedure is identical to general procedure I, except that reactions were conducted at 0.2 M concentration with N-oxide (1.00 equiv), POBr3 (3.00 equiv), DMF (1.50 equiv) at rt. 4.2 General procedure I for the bromination of azine N-oxides (0013) To a stirred solution of the appropriate azine N-oxides in anhydrous CH2Cl2 (0.1 M) at 0 C is added POBr3 (1.2 equiv) followed by dropwise addition of DMF (0.5 equiv) under argon. The resulting reaction mixture was warmed to 25 C and stirred for several hours until the reaction is complete as indicated by TLC. Saturated aqueous sodium carbonate solution is added to the reaction mixture slowly to adjust the pH to 7-8. The resulting mixture is separated and the aqueous phase is extracted with CH2Cl2 thoroughly. The organic phase is combined and washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to afford the crude product, which is purified by flash column chromatography using PE/EA (100:1) as eluent.

Reference： [1]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[2]Tetrahedron,2016,vol. 72,p. 5762 - 5768

17
[ 34413-35-9 ]
[ 6935-29-1 ]

18
[ 2423-66-7 ]
[ 6935-29-1 ]
[ 23719-78-0 ]
[ 36856-91-4 ]

Yield	Reaction Conditions	Operation in experiment
45%; 20%; 25%	With triethylamine; phosphorus(V) oxybromide; In dichloromethane; at 20 - 40℃; for 1.5h;Inert atmosphere;	General procedure: A solution of POBr3 (1.67g, 5.8mmol) in methylene chloride (200mL) was added dropwise to a magnetically stirred solution of quinoxaline-N-oxide (325mg gr, 2.0mmol) 26 in mixture of methylene chloride (10mL) and triethylamine (510mg, 5.0mmol). The resulting mixture was stirred for 30minat room temperature and 1h at 40C. The mixture was diluted with solution of sodium hydroxide (10%, 10mL) and the aqueous solution was extracted with methylene chloride (2×50mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The residue was purified via column chromatography on silica gel (50g) by eluting with 10% EtOAc/n-hexane.

Reference： [1]Tetrahedron,2017,vol. 73,p. 1618 - 1632

19
[ 3476-89-9 ]
[ 6935-29-1 ]

Reference： [1]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[2]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[3]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[4]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[5]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[6]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[7]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[8]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[9]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[10]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[11]Tetrahedron,2017,vol. 73,p. 1618 - 1632
[12]Tetrahedron,2017,vol. 73,p. 1618 - 1632

20
[ 6935-29-1 ]
[ 1076-96-6 ]
(E)-2-(4-(methoxycarbonyl)styryl)quinoxaline 1-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With Fmoc-Val-OH; silver(I) acetate; palladium diacetate; In 1,4-dioxane; at 120℃; for 12h;Inert atmosphere; Sealed tube;	General procedure: Pd(OAc)2 (1.9 mg, 0.0085mmol, 10 mol%) Ag2CO3 (35.3 mg, 0.128 mmol, 1.5 equiv.), quinoxaline N-oxide (50 mg, 0.342 mmol, 4 equiv) and Fmoc-Val-OH (0.0138, 0.0855 mmol, 1 equiv) were added to 1 mL amber screw-capped vial, equipped with a stirring bar. Following addition of solid compounds, the vial was hermetically sealed with Teflon-lined cap, and the reaction medium was purged with nitrogen. Previously dried 1,4-dioxane (0.5 mL) and the alkene (0.0855 mmol) were added into solid mixture, with syringe assistance. The reaction mixture was stirred at 120 C for 12 hours. The reaction was cooled until room temperature, filtered by assistance of a plug of celite, washed with ethyl acetate (30 mL), the solvent was removed under reduced pressure.

Reference： [1]Tetrahedron Letters,2018,vol. 59,p. 2562 - 2566

21
[ 6935-29-1 ]
[ 2628-16-2 ]
(E)-2-(4-acetoxystyryl)quinoxaline 1-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With Fmoc-Val-OH; palladium diacetate; silver carbonate In 1,4-dioxane at 120℃; for 12h; Inert atmosphere; Sealed tube;	Alkenylation reaction: General procedure: Pd(OAc)2 (1.9 mg, 0.0085mmol, 10 mol%) Ag2CO3 (35.3 mg, 0.128 mmol, 1.5 equiv.), quinoxaline N-oxide (50 mg, 0.342 mmol, 4 equiv) and Fmoc-Val-OH (0.0138, 0.0855 mmol, 1 equiv) were added to 1 mL amber screw-capped vial, equipped with a stirring bar. Following addition of solid compounds, the vial was hermetically sealed with Teflon-lined cap, and the reaction medium was purged with nitrogen. Previously dried 1,4-dioxane (0.5 mL) and the alkene (0.0855 mmol) were added into solid mixture, with syringe assistance. The reaction mixture was stirred at 120 °C for 12 hours. The reaction was cooled until room temperature, filtered by assistance of a plug of celite, washed with ethyl acetate (30 mL), the solvent was removed under reduced pressure.

Reference： [1]Freire Franco, Márcia Silvana; de Paula, Murilo Helder; Glowacka, Paulina Cecylia; Fumagalli, Fernando; Clososki, Giuliano Cesar; da Silva Emery, Flavio [Tetrahedron Letters, 2018, vol. 59, # 26, p. 2562 - 2566]

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P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6935-29-1 ] {[proInfo.proName]}

Quality Control of [ 6935-29-1 ]

Related Doc. of [ 6935-29-1 ]

Product Details of [ 6935-29-1 ]

Safety of [ 6935-29-1 ]

Application In Synthesis of [ 6935-29-1 ]

[ 6935-29-1 ] Synthesis Path-Upstream 1~8

[ 6935-29-1 ] Synthesis Path-Downstream 1~21

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry