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Chemical Structure| 69385-30-4 Chemical Structure| 69385-30-4

Structure of 2,6-Difluorobenzylamine
CAS No.: 69385-30-4

Chemical Structure| 69385-30-4

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Product Details of [ 69385-30-4 ]

CAS No. :69385-30-4
Formula : C7H7F2N
M.W : 143.13
SMILES Code : NCC1=C(F)C=CC=C1F
MDL No. :MFCD00010144
InChI Key :PQCUDKMMPTXMAL-UHFFFAOYSA-N
Pubchem ID :123563

Safety of [ 69385-30-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 69385-30-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69385-30-4 ]

[ 69385-30-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 207399-07-3 ]
  • [ 69385-30-4 ]
  • C43H50F2N3(1+)*I(1-) [ No CAS ]
  • 2
  • [ 171879-99-5 ]
  • [ 69385-30-4 ]
  • N-[(2,6-difluorophenyl)methyl]-6-methyl-1H-pyrrolo[2,3-b]pyridin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With toluene-4-sulfonic acid; In water; acetonitrile; at 20 - 150℃; for 4.0h;Inert atmosphere; Microwave irradiation; To a solution of 4-chloro-6-methyl-lH-pyrrolo[2,3-]pyridine (0.5 g, 3 mmol) in MeCN (15 mL) was added 2,6-difluorobenzylamine (2 eq) and pTSA.H20 (2 eq) under N2 at room temperature. The reaction mixture was heated at 150 C in a CEM microwave reactor for 4 hours. The mixture was diluted with sat. aq. NaHC03 (20 mL) solution and EtOAc (20 mL). The organic layer was separated, washed with brine, dried over MgSC^ and concentrated in vacuo. The residue was purified via flash chromatography using MeOH and DCM as eluent to give the product (0.521 g, 1.90 mmol, 63%) as yellow solid. 1H NMR (399 MHz, DMSO-d6) delta 10.96 (s, 1H), 7.43 (tt, 1H), 7.20 - 7.08 (m, 2H), 6.95 (d, 1H), 6.77 (t, 1H), 6.53 (d, 1H), 6.15 (s, 1H), 4.44 (d, 2H), 2.35 (s, 3H).
 

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