[ CAS No. 69584-91-4 ] {[proInfo.proName]}

Name: 69584-91-4|1'-Methylspiro[indoline-3,4'-piperidine]|95%
Brand: Ambeed
SKU: A284785
Price: 118.0 USD
Availability: InStock
Rating: 91 (22 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 69584-91-4

Structure of 69584-91-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 69584-91-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 69584-91-4 ]

SDS Specification

Alternatived Products of [ 69584-91-4 ]

Product Details of [ 69584-91-4 ]

CAS No. :	69584-91-4	MDL No. :	MFCD12198567
Formula :	C₁₃H₁₈N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	NPUZJRBPYOYUMS-UHFFFAOYSA-N
M.W :	202.30	Pubchem ID :	12801587
Synonyms :

Calculated chemistry of [ 69584-91-4 ] Expand+

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.54
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	70.15
TPSA :	15.27 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.92 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.28
Log Po/w (XLOGP3) :	2.27
Log Po/w (WLOGP) :	1.12
Log Po/w (MLOGP) :	2.28
Log Po/w (SILICOS-IT) :	2.34
Consensus Log Po/w :	2.06

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.82
Solubility :	0.306 mg/ml ; 0.00151 mol/l
Class :	Soluble
Log S (Ali) :	-2.23
Solubility :	1.2 mg/ml ; 0.00592 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.83
Solubility :	0.0302 mg/ml ; 0.000149 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.2

Safety of [ 69584-91-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 69584-91-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 69584-91-4 ]
Downstream synthetic route of [ 69584-91-4 ]

[ 69584-91-4 ] Synthesis Path-Upstream 1~5

1
[ 184289-84-7 ]
[ 69584-91-4 ]

Reference： [1] Patent: EP1726590, 2006, A1, . Location in patent: Page/Page column 60

2
[ 69584-88-9 ]
[ 69584-91-4 ]

Reference： [1] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986

3
[ 69584-88-9 ]
[ 69584-91-4 ]
[ 85422-39-5 ]

Reference： [1] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986

4
[ 326-62-5 ]
[ 69584-91-4 ]

Reference： [1] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986

5
[ 55-86-7 ]
[ 69584-91-4 ]

Reference： [1] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 981 - 986

[ 69584-91-4 ] Synthesis Path-Downstream 1~38

1
[ 462-06-6 ]
[ 69584-91-4 ]
[ 69585-02-0 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

2
[ 372-48-5 ]
[ 69584-91-4 ]
[ 81049-98-1 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

3
[ 348-51-6 ]
[ 69584-91-4 ]
[ 69585-10-0 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

4
[ 540-36-3 ]
[ 69584-91-4 ]
[ 69585-00-8 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

5
[ 352-33-0 ]
[ 69584-91-4 ]
[ 69584-97-0 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

6
[ 367-11-3 ]
[ 69584-91-4 ]
[ 69585-04-2 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

7
[ 402-44-8 ]
[ 69584-91-4 ]
[ 69584-96-9 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

8
[ 401-80-9 ]
[ 69584-91-4 ]
[ 69584-99-2 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

9
[ 69584-88-9 ]
[ 69584-91-4 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

10
[ 69584-88-9 ]
[ 69584-91-4 ]
[ 85422-39-5 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

11
[ 69584-91-4 ]
[ 1493-27-2 ]
[ 69585-08-6 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

12
[ 501-53-1 ]
[ 69584-91-4 ]
[ 167483-90-1 ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

13
[ 69584-91-4 ]
[ 167483-91-2 ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

14
[ 69584-91-4 ]
[ 180465-77-4 ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

15
[ 69584-91-4 ]
[ 159635-06-0 ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

16
[ 69584-91-4 ]
C₃₅H₄₁N₃O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

17
[ 69584-91-4 ]
[ 159635-05-9 ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 1767 - 1770

18
[ 326-62-5 ]
[ 69584-91-4 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986
[2]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

19
[ 55-86-7 ]
[ 69584-91-4 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986
[2]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

20
[ 69584-91-4 ]
[ 69585-03-1 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

21
[ 69584-91-4 ]
[ 69585-01-9 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

22
[ 69584-91-4 ]
[ 81049-94-7 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

23
[ 69584-91-4 ]
[ 75391-72-9 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

24
[ 69584-91-4 ]
[ 81049-89-0 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

25
[ 69584-91-4 ]
[ 81049-99-2 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

26
[ 69584-91-4 ]
[ 69585-07-5 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

27
[ 69584-91-4 ]
[ 81049-92-5 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

28
[ 69584-91-4 ]
[ 81049-95-8 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

29
[ 69584-91-4 ]
[ 75391-68-3 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

30
[ 69584-91-4 ]
[ 81049-90-3 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 981 - 986

31
methane sulfonyl chloride [ No CAS ]
MeOH(NH₃) [ No CAS ]
[ 144-55-8 ]
[ 69584-91-4 ]
[ 7087-68-5 ]
[ 165125-51-9 ]

Yield	Reaction Conditions	Operation in experiment
3.37 g (81%)	In dichloromethane;	Preparation 1 1,2-Dihydro-1'-methyl-1-(methylsulfonyl)-spiro[3H-indole-3,4'-piperidine] Dissolve <strong>[69584-91-4]1,2-dihydro-1'-methyl-spiro[3H-indole-3,4'-piperidine]</strong> (3.0 g, 14.8 mmoles) in dry CH2 Cl2 (25 ml) and cool under N2 in an ice bath. Add, dropwise, methane sulfonyl chloride (1.5 ml, 19.3 mmoles), followed by ethyl diisopropyl amine (5.0 ml, 28.7 mmoles). Warm to room temperature and stir overnight. Dilute the solution to 100 ml with CH2 Cl2. Wash the solution with saturated aqueous NaHCO3 (4*25 ml), then with water. Dry solution with anhydrous Na2 SO4, then remove the solvent using reduced pressure. Purify the resulting reaction mixture by flash chromatography (SiO2) using 5% MeOH(NH3)/EtOAc as eluent. Yield: 3.37 g (81%) of the title compound. HRMS (FAR): calculated for C14 H21 N2 O2 S (M+H)+: 281.1324; found: 281.1324.

Reference： [1]Patent: US5945428,1999,A

32
[ 501-53-1 ]
[ 69584-91-4 ]
[ 121-44-8 ]
[ 167483-90-1 ]

Yield	Reaction Conditions	Operation in experiment
117 g (71%)	In methanol; dichloromethane;	EXAMPLE 4 1-Benzyloxycarbonyl-spiro(indoline-3,4'-piperidinium) hydrochloride A solution of 99 g (489 mmol) of 1'-methylspiro(indoline-3,4'-piperidine) (prepared according to Ong, H. H. et al, J. Med. Chem., 1983, 26, 981-986) in 1 L of CH2 Cl2 and 82 mL (539 mmol) of Et3 N was cooled to 0-5 C. with an ice bath and 77 mL (539 mmol) of benzyl chloroformate was added over 30 min keeping the reaction temperature below 10 C. After stirring for 2 h 19 mL (136 mmol) of Et3 N and 15 mL (105 mmol) of benzyl chloroformate were added since the reaction was incomplete and stirred for 2 h. At this time, additional 19 mL (136 mmol) of Et3 N and 15 mL (105 mmol) of benzyl chloroformate were added. After 1 h, when a TLC indicated a complete reaction, the solution was concentrated in vacuo and the residue was partitioned between ether and saturated NaHCO3. The layers were separated, the organic layer was washed with saturated NaHCO3 and brine, and dried over MgSO4. The filtrate was concentrated and the residue was chromatographed on 2 kg of silica gel using 1-5% MeOH/CH2 Cl2 to obtain 117 g (71%) of 1-benzyloxycarbonyl-1'-methylspiro(indoline-3,4'-piperidine) as a yellow oil. The yellow oil was dissolved in 800 mL of 1,2-dichloroethane and cooled in ice bath as 50 mL (463 mmol) of 1-chloroethyl chloroformate keeping the temperature below 10 C. The resulting solution was heated to reflux. Gas evolution was noticed when the reaction temperature reached 70-75 C. After 1 h the solution was cooled, concentrated to ca. 250 mL in vacuo and 700 mL of methanol was added. The mixture was refluxed for 1.5 h and gas evolution was observed. The reaction was cooled to room temperature and concentrated in vacuo to a wet solid. The solid was slurried with cold methanol, the solid was filtered, washed with cold methanol and dried. The filtrates and the washing were combined and concentrated to a brown foam. The brown foam and the filtered solid were suspended in CH2 Cl2, washed with 2.5 N NaOH and the CH2 Cl2 solution was dried.
117 g (71%)	In methanol; dichloromethane;	EXAMPLE 4 1-Benzyloxycarbonyl-spiro(indoline-3,4'-piperidinium)hydrochloride A solution of 99 g (489 mmol) of 1'-methylspiro(indoline-3,4'-piperidine) (prepared according to Ong, H. H. et al, J. Med. Chem., 1983, 26, 981-986) in 1 L of CH2 Cl2 and 82 mL (539 mmol) of Et3 N was cooled to 0-5 C. with an ice bath and 77 mL (539 mmol) of benzyl chloroformate was added over 30 min keeping the reaction temperature below 10 C. After stirring for 2 h 19 mL (136 mmol) of Et3 N and 15 mL (105 mmol) of benzyl chloroformate were added since the reaction was incomplete and stirred for 2 h. At this time, additional 19 mL (136 mmol) of Et3 N and 15 mL (105 mmol) of benzyl chloroformate were added. After 1 h, when a TLC indicated a complete reaction, the solution was concentrated in vacuo and the residue was partitioned between ether and saturated NaHCO3. The layers were separated, the organic layer was washed with saturated NaHCO3 and brine, and dried over MgSO4. The filtrate was concentrated and the residue was chromatographed on 2 kg of silica gel using 1-5% MeOH/CH2 Cl2 to obtain 117 g (71%) of 1-benzyloxycarbonyl-1'-methylspiro(indoline-3,4'-piperidine) as a yellow oil. The yellow oil was dissolved in 800 mL of 1,2-dichloroethane and cooled in ice bath as 50 mL (463 mmol) of 1-chloroethyl chloroformate keeping the temperature below 10 C. The resulting solution was heated to reflux. Gas evolution was noticed when the reaction temperature reached 70-75 C. After 1 h the solution was cooled, concentrated to ca. 250 mL in vacuo and 700 mL of methanol was added. The mixture was refluxed for 1.5 h and gas evolution was observed. The reaction was cooled to room temperature and concentrated in vacuo to a wet solid. The solid was slurried with cold methanol, the solid was filtered, washed with cold methanol and dried. The filtrates and the washing were combined and concentrated to a brown foam. The brown foam and the filtered solid were suspended in CH2 Cl2, washed with 2.5 N NaOH and the CH2 Cl2 solution was dried.

Reference： [1]Patent: US5962462,1999,A
[2]Patent: US6013652,2000,A

33
[ 50-00-0 ]
[ 69584-91-4 ]
1,1'-dimethyl-spiro[indoline-3,4'-piperidine] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		With cooling with ice, 187 mg of sodium cyanoborohydride was added to methanol (10 mL) solution of 0.30 g of the compound obtained in the above 1. Its pH was controlled to 4 to 5 with 1 % hydrochloric acid added thereto, and 3 mL of 37 % formaldehyde solution was added thereto and stirred at room temperature for 7.5 hours. The solvent was evaporated off under reduced pressure, and the residue was diluted with ethyl acetate, washed with aqueous 1 M sodium hydroxide solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was separated and purified through silica gel column chromatography (chloroform/methanol = 10/1) to obtain 243 mg of the entitled compound.

Reference： [1]Patent: EP1726590,2006,A1 .Location in patent: Page/Page column 60

34
[ 184289-84-7 ]
[ 69584-91-4 ]

Yield	Reaction Conditions	Operation in experiment
		In a nitrogen atmosphere, 3.8 mL of 65 % sodium-bis(2-methoxyethoxy)aluminium hydride-toluene solution was added to toluene (20 mL) solution of 1 g of benzyl 1-methanesulfonyl-spiro[2,3-dihydro-1H-indole-3,4'-piperidine]-1'-carboxylate (prepared according to the method described in Tetrahedron, 1997, 53, 10983-10992), and refluxed for 3 hours. The reaction liquid was cooled to 0C, poured into aqueous 1 M sodium hydroxide solution at that temperature, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was separated and purified through silica gel column chromatography (aqueous 1 % ammonia, chloroform/methanol = 5/1) to obtain 0.32 g of the entitled compound.

Reference： [1]Patent: EP1726590,2006,A1 .Location in patent: Page/Page column 60

35
methane sulfonyl chloride [ No CAS ]
MeOH(NH₃) [ No CAS ]
[ 69584-91-4 ]
[ 7087-68-5 ]
[ 165125-51-9 ]

Yield	Reaction Conditions	Operation in experiment
3.37 g (81%)	In dichloromethane;	Preparation 1 1,2-Dihydro-1'-methyl-1-(methylsulfonyl)-spiro[3H-indole-3,4'-piperidine] Dissolve <strong>[69584-91-4]1,2-dihydro-1'-methyl-spiro[3H-indole-3,4'-piperidine]</strong> (3.0g, 14.8 mmoles) in dry CH2Cl2 (25 ml) and cool under N2 in an ice bath. Add, dropwise, methane sulfonyl chloride (1.5 ml, 19.3 mmoles), followed by ethyl diisopropyl amine (5.0 ml, 28.7 mmoles). Warm to room temperature and stir overnight. Dilute the solution to 100 ml with CH2Cl2. Wash the solution with saturated aqueous NaHCO3 (4x25 ml), then with water. Dry solution with anhydrous Na2SO4, then remove the solvent using reduced pressure. Purify the resulting reaction mixture by flash chromatography (SiO2) using 5% MeOH(NH3)/EtOAc as eluent. Yield: 3.37 g (81%) of the title compound. HRMS (FAR): calculated for C14H21N2O2S (M+H)+: 281.1324; found: 281.1324.

Reference： [1]Patent: EP937076,2002,B1

36
[ 64-18-6 ]
[ 69584-91-4 ]
[ 1025687-97-1 ]

Yield	Reaction Conditions	Operation in experiment
99%	In toluene; for 16.0h;Reflux;	A solution of 1 ,2-dihydro-1'-methyl-spiro[3H-indole-3,4'-piperidine] (29.8 g, 0.148 mol; CASNo. 69584-91-4; J. Med Chem. 1983, 26, 981-986) in toluene (737 mL) was treated with formic acid (27.8 mL, 0.737 mol). The reaction vessel was fitted with a Dean-Stark trap and the reaction mixture, which appears as two layers, was heated at reflux under nitrogen with azeotropic removal of water for 16 h. The reaction mixture was coole to room temperature and concentrated <n="204"/>invacuo. The residue was partitioned between chloroform (500 ml_) and 3N aq. NaOH (300 ml_). The organic layer was extracted three more times with N aq. NaOH (300 ml_), dried over anhydrous K2CO3, and filtered. The filtrate was concentrated in vacuo to furnish 6a (33.5 g, 99%) as a beige solid.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 2114 - 2121
[2]Patent: WO2009/67202,2009,A1 .Location in patent: Page/Page column 202-203

37
7-chloro-N-tetrahydropyran-4-yl-thiazolo[5,4-d]pyrimidine-2-carboxamide [ No CAS ]
[ 69584-91-4 ]
7-(1‘-methylspiro[indole-3,4‘-piperidin]-1(2H)-yl)-N-(tetrahydro-2H-pyran-4-yl)[1,3]thiazolo[5,4-d]pyrimidine-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
8%	In isopropyl alcohol; at 80℃; for 4.0h;	A mixture of Intermediate 18 (78 mg, 0.262 mmol) and 1?-methyl-1,2-dihydrospiro-[indole-3,4?-piperidine] (53 mg, 0.262 mmol) in IPA (3 ml) was stirred and heated at80C for 4 hours. The mixture was allowed to cool to rt, diluted with MeOH and theresulting solution was passed through a SCX cartridge. The product was eluted with 2M NH3 in MeOH and the eluent was concentrated. The residue was purified by flashcolumn chromatography on silica gel eluting with 50:1 to 25:1 DCM: 2 M NH3 in MeOH.Recrystallization of the chromatographed material from EtOAc gave a pale yellow solid(10 mg, 8%). 1H NMR (400 MHz, DMSO-d6) oe ppm 1.61 -1.77 (m, 4 H)1 1.82-2.03 (m,4 H), 2.07 - 2.28 (m, 5 H), 2.75 - 2.87 (m, 2 H), 3.46 (td, P1 1.33, 2.06 Hz1 2 H), 3.85 -3.95 (m, 2 H), 4.00 - 4.15 (m, I H), 4.79 (s, 2 H), 7.09 - 7.17 (m, I H), 7.27 - 7.35 (m, 1H), 7.38 (d, J=7.33 Hz, I H), 8.55 (d, J8.24 Hz, I H), 8.62 - 8.74 (m, 2 H). m/z (ESi-APCI): 465 [M-i-H]

Reference： [1]Patent: WO2017/85484,2017,A1 .Location in patent: Page/Page column 116

38
[ 69584-91-4 ]
[ 208932-96-1 ]

Reference： [1]Patent: EP1726590,2006,A1

Recommend Products

Same Skeleton Products

Related Products

Isomers

Historical Records

Related Parent Nucleus of
[ 69584-91-4 ]

Indolines

[ 1914-02-9 ]

3,3-Dimethylindoline

Similarity: 0.82

[ 913179-36-9 ]

5'-Fluorospiro[cyclopropane-1,3'-indoline]

Similarity: 0.79

[ 905274-11-5 ]

(Indolin-4-yl)methanol

Similarity: 0.79

[ 22120-50-9 ]

2,3-Dimethylindoline

Similarity: 0.77

[ 252882-61-4 ]

Spiro[indoline-3,4'-piperidin]-2-one

Similarity: 0.77

Piperidines

[ 147769-93-5 ]

(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine

Similarity: 0.85

[ 19733-56-3 ]

4-(Piperidin-3-yl)aniline

Similarity: 0.83

[ 454482-12-3 ]

4-(1-Methylpiperidin-4-yl)aniline

Similarity: 0.83

[ 113310-52-4 ]

4-(Piperidin-4-yl)aniline

Similarity: 0.79

[ 252882-61-4 ]

Spiro[indoline-3,4'-piperidin]-2-one

Similarity: 0.77

Spiroes

[ 913179-36-9 ]

5'-Fluorospiro[cyclopropane-1,3'-indoline]

Similarity: 0.79

[ 252882-61-4 ]

Spiro[indoline-3,4'-piperidin]-2-one

Similarity: 0.77

[ 1588441-25-1 ]

2,3-Dihydro-1H-spiro[isoquinoline-4,4'-piperidine] dihydrochloride

Similarity: 0.73

[ 356072-46-3 ]

Spiro[indoline-3,4'-piperidin]-2-one hydrochloride

Similarity: 0.67

[ 635713-68-7 ]

1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one

Similarity: 0.66

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 69584-91-4 ] {[proInfo.proName]}

Quality Control of [ 69584-91-4 ]

Related Doc. of [ 69584-91-4 ]

Product Details of [ 69584-91-4 ]

Calculated chemistry of [ 69584-91-4 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 69584-91-4 ]

Application In Synthesis of [ 69584-91-4 ]

[ 69584-91-4 ] Synthesis Path-Upstream 1~5

[ 69584-91-4 ] Synthesis Path-Downstream 1~38

Related Parent Nucleus of [ 69584-91-4 ]

Indolines

Piperidines

Spiroes

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Parent Nucleus of
[ 69584-91-4 ]