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[ CAS No. 7012-88-6 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 7012-88-6
Chemical Structure| 7012-88-6
Chemical Structure| 7012-88-6
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Quality Control of [ 7012-88-6 ]

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Product Details of [ 7012-88-6 ]

CAS No. :7012-88-6 MDL No. :MFCD11048436
Formula : C9H7ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :HSXQJNOGRWBTBQ-UHFFFAOYSA-N
M.W : 194.62 Pubchem ID :135462579
Synonyms :

Calculated chemistry of [ 7012-88-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 13
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.11
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 52.34
TPSA : 45.75 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.21 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.51
Log Po/w (XLOGP3) : 1.8
Log Po/w (WLOGP) : 1.88
Log Po/w (MLOGP) : 2.01
Log Po/w (SILICOS-IT) : 3.15
Consensus Log Po/w : 2.07

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.75
Solubility : 0.346 mg/ml ; 0.00178 mol/l
Class : Soluble
Log S (Ali) : -2.38
Solubility : 0.812 mg/ml ; 0.00417 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.24
Solubility : 0.0111 mg/ml ; 0.0000573 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.72

Safety of [ 7012-88-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338-P280 UN#:N/A
Hazard Statements:H317-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 7012-88-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7012-88-6 ]

[ 7012-88-6 ] Synthesis Path-Downstream   1~50

  • 1
  • [ 708-73-6 ]
  • [ 7012-88-6 ]
YieldReaction ConditionsOperation in experiment
3.6 g With ammonium hydroxide; at 25℃; General procedure: The benzoxazin-4-one intermediates (1 mmol) were suspended in concentrated ammonium hydroxide (1 ml) and were stirred at room temperature overnight. 10% sodium hydoxide solution was added to the reaction mixtures until the results of transparent solutions. The pH was adjusted to 7 with acetic acid. The products precipitated from the solution were filtered out and were washed with water. The solid compounds were dried under vacuum overnight.
YieldReaction ConditionsOperation in experiment
With ammonium hydroxide; at 20℃; General procedure: 6-chloro-2-methylquinazolin-4(3H)-one 10 g (58 mmol) 2-amino-5-chlorobenzoic acid was solved in 35 ml acetic anhydride and was stirred at reflux temperature for 4 hours. The reaction mixture was cooled down to room temperature and the solvent was rotary evaporated. The crude product was washed with hexane/ether 2:1 and than filtered. The solid 6-chloro-2-methyl-4H-3,1-benzoxazin-4-one (58 mmol) was suspended in 80 ml concentrated ammonium hydroxide and stirred at room temperature overnight. 10 % sodium hydoxide solution was given to the reaction mixture resulting a transparent solution. The pH was adjusted to 7 with acetic acid. The product, which was precipitated from the solution, was filtered, washed with water and dried under vacuum overnight. Preparation of other 2-methylquinazolin-4(3H)-one derivatives were carried out with the same method. Yield: 8.76 g (77 %) 1H NMR (300 MHz, DMSO-d6) delta ppm 7.98 (s, 1H); 7,76 (6Hz, d, 1H); 7.57 (9 Hz, d, 1H); 2.34 (s, 3H). LC-MS (ESI): m z (M+H)+ 195, Rt: 2.43 min.
  • 5
  • [ 7012-88-6 ]
  • 4,7-dichloro-2-[2-(3-nitrophenyl)vinyl]quinazoline [ No CAS ]
  • 6
  • [ 7012-88-6 ]
  • 8-chloro-5-[2-(3-nitro-phenyl)-vinyl]-2<i>H</i>-imidazo[1,2-<i>c</i>]quinazolin-3-one [ No CAS ]
  • 8
  • [ 7012-88-6 ]
  • 2-(2'-Chlorostyryl)-4-(δ-diethylamino-α-methylbutylamino)-7-chloroquinazoline disulfate [ No CAS ]
  • 13
  • [ 7012-88-6 ]
  • [ 80-48-8 ]
  • [ 7012-89-7 ]
YieldReaction ConditionsOperation in experiment
0.73 g (73%) With sodium hydroxide; lithium hydroxide monohydrate; In tetrahydrofuran; water; EXAMPLE 5 7-Chloro-2,3-dimethyl-4(3H)-quinazolinone A mixture of 0.96 g (5.0 mmol) of <strong>[7012-88-6]7-chloro-2-methyl-4(3H)-quinazolinone</strong> and 0.20 g (4.8 mmol) of lithium hydroxide monohydrate in 25 ml of tetrahydrofuran is heated at reflux with stirring for 0.5 h. After cooling to room temperature, 0.89 g (4.8 mmol) of methyl p-toluene sulfonate is added and the reaction mixture heated at reflux for 4 hours. The reaction mixture is neutralized with con. HCl and the solvent removed in vacuo to give a residue. The residue is slurried with 50 ml of water, filtered, washed with 50 ml of 0.5M sodium hydroxide, followed by (3*50 ml) of water. The solid is dried to give 0.73 g (73%) of the desired product, m.p. 162-165 C. None of the isomeric O-alkylated product is detected by HPLC.
  • 14
  • [ 942319-20-2 ]
  • [ 143-37-3 ]
  • [ 7012-88-6 ]
  • 15
  • [ 13421-13-1 ]
  • [ 124-42-5 ]
  • [ 7012-88-6 ]
  • 16
  • [ 7012-88-6 ]
  • [ 1258285-90-3 ]
  • 17
  • [ 7012-88-6 ]
  • [ 1258285-91-4 ]
  • 18
  • [ 7012-88-6 ]
  • [ 1258327-25-1 ]
  • 19
  • [ 7012-88-6 ]
  • C19H13ClN2O [ No CAS ]
  • 20
  • [ 5900-59-4 ]
  • [ 7012-88-6 ]
  • 21
  • [ 7033-57-0 ]
  • [ 7012-88-6 ]
  • 22
  • [ 7012-88-6 ]
  • (E)-N1-(7-chloro-2-(3,4-dichlorostyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine [ No CAS ]
  • 23
  • [ 7012-88-6 ]
  • [ 6287-38-3 ]
  • (E)-7-chloro-2-(3,4-dichlorostyryl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.8 g With acetic acid; at 120℃; for 8h;Sealed tube; (E)-7-Chloro-2-(3,4-dichlorostyryl)quinazolin-4(3H)-one 7-Chloro-2-methylquinazolin-4(3H)-one (1.0 g, 5.14 mmol, 1 eq) was placed in a 40 ml screw-top vial with a stir bar. Added 3,4-dichlorobenzaldehyde (1.0 g, 5.71 mmol) was added and acetic acid (15 ml) was added to the mixture. The mixture was placed on a pre-heated hotplate-stirrer (120 C.) for 8 hrs. The reaction was cooled and the precipitate was vacuum filtered, washed with water, sat'd NaHCO3 solution, water and a small amount of diethyl ether to remove the excess aldehyde. The solid was dried in a vacuum desiccator to give 1.80 grams of 411. (E)-7-chloro-2-(3,4-dichlorostyryl)quinazolin-4(3H)-one. 1H NMR (400 MHz, DMSO-d6): delta 12.4 (bs, 1H), 8.1 (d, 1H), 7.86-7.96 (m, 2H), 7.64-7.76 (m, 3H), 7.50-7.55 (m, 1H), 7.65 (d, 1H).
  • 24
  • [ 108-24-7 ]
  • [ 89-77-0 ]
  • [ 7012-88-6 ]
YieldReaction ConditionsOperation in experiment
10 mg 7-Chloro-2-methylquinazolin-4(3H)-one (1230) (1231) Placed 2-amino-4-chlorobenzoic acid (10.0 g, 58.28 mmol, 1 eq) in a 1000 ml round bottom flask with a stir bar. Added acetic anhydride (21.6 g, 20 ml, 211.5 mmol, 3.6 eq) and placed on a pre-heated oil bath at 120 C. for 3 h with stirring. This mixture was then placed on a rotary evaporator (50 C.) to remove excess acetic anhydride which gave a dry solid. To this was added 100 ml of ammonium hydroxide (28% NH3) and heated to 95 C. for 4 h. Cooled, vacuum filtered and washed the solid with water (500 ml), then Et2O (100 ml), and dried in vacuo to give 10 grams of 410. 1H NMR (400 MHz, DMSO-d6), S 12.3 (bs, 1H), 8.0-8.1 (m, 1H), 7.61 (s, 1H), 7.4-7.5 (m, 1H), 2.35 (s, 3H).
  • 25
  • [ 75-05-8 ]
  • [ 89-77-0 ]
  • [ 7012-88-6 ]
  • 26
  • [ 7012-88-6 ]
  • C16H10Cl2N2 [ No CAS ]
  • 27
  • [ 7012-88-6 ]
  • (E)-N4-(7-chloro-2-styrylquinazolin-4-yl)-N1,N1-diethylpentane-1,4-diamine [ No CAS ]
  • 28
  • [ 7012-88-6 ]
  • [ 100-52-7 ]
  • [ 127033-30-1 ]
  • 29
  • [ 5900-56-1 ]
  • [ 7012-88-6 ]
  • 30
  • [ 7012-88-6 ]
  • [ 490-63-1 ]
  • [ 106-49-0 ]
  • 7-chloro-2-((5,6-dimethoxy-3-oxo-2-p-tolylisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 31
  • [ 7012-88-6 ]
  • [ 106-49-0 ]
  • [ 119-67-5 ]
  • 7-chloro-2-((3-oxo-2-p-tolylisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 32
  • [ 7012-88-6 ]
  • [ 490-63-1 ]
  • [ 62-53-3 ]
  • 7-chloro-2-((5,6-dimethoxy-3-oxo-2-phenylisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 33
  • [ 7012-88-6 ]
  • [ 62-53-3 ]
  • [ 119-67-5 ]
  • 7-chloro-2-((3-oxo-2-phenylisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 34
  • [ 7012-88-6 ]
  • [ 490-63-1 ]
  • [ 104-94-9 ]
  • 7-chloro-2-((5,6-dimethoxy-2-(4-methoxyphenyl)-3-oxoisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 35
  • [ 7012-88-6 ]
  • [ 119-67-5 ]
  • [ 589-16-2 ]
  • 7-chloro-2-((2-(4-ethylphenyl)-3-oxoisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 36
  • [ 7012-88-6 ]
  • [ 104-94-9 ]
  • [ 119-67-5 ]
  • 7-chloro-2-((2-(4-methoxyphenyl)-3-oxoisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 37
  • [ 7012-88-6 ]
  • [ 371-40-4 ]
  • [ 119-67-5 ]
  • 7-chloro-2-((2-(4-fluorophenyl)-3-oxoisoindolin-1-yl)methyl)quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With acetic acid; In water; for 24h;Reflux; Green chemistry; General procedure: A mixture of 2-methylquinazolin-4(3H)-ones 1 (2 mmol), aryl amines 2 (2 mmol), and 2-formylbenzoic acids 3 (2 mmol), and acetic acid (40 mol) in H2O (6 mL) were refluxed for 24 hours. After reaction completion (TLC), the reaction mixture was cooled to room temperature. Then the obtained solid was filtered off, washed with cold water (20 mL) and recrystallized from aqueous EtOH to afford the pure product 4a-n.
  • 38
  • [ 64-17-5 ]
  • [ 5900-59-4 ]
  • [ 7012-88-6 ]
  • 39
  • [ 5900-59-4 ]
  • [ 78-39-7 ]
  • [ 7012-88-6 ]
YieldReaction ConditionsOperation in experiment
94% With acetic acid; In ethanol; at 110℃; for 24h;Inert atmosphere; Sealed tube; General procedure: The 2-aminobenzamide (1 equiv), the orthoester (2?3 equiv) and absolute ethanol (2?3 mL) wereplaced in a 15-mL Chemglass screw-cap pressure tube (No. CG-1880-01, Chemglass, Vineland, NJ,USA). Glacial acetic acid (3 equiv) was added, N2 was introduced to the vessel and the cap wastightened. The vessel was heated at 110 °C for 12?72 h, then cooled and concentrated to give thequinazolinone, which was purified by crystallization from absolute ethanol or trituration from 5percentether in pentane. The following compounds were prepared:
  • 40
  • [ 7012-88-6 ]
  • [ 123-11-5 ]
  • 7-chloro-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With sulfuric acid; at 190℃; under 750.075 - 5250.53 Torr; for 1.5h;Microwave irradiation; General procedure: The 2-methylquinazolin-4(3H)-ones (1 mmol) were mixed with benzaldehydes (1.5 mmol) and 1 drop concentrated sulphuric acid was added to the mixtures. The reaction was carried out in microwave set (Personal Chemistry, Emrys Creator, heating power: 150 W, measured pressure 1-7 bar, reaction time: 1.5 hours) at 190 C. The crude product was washed with 5% sodium hydrogen carbonate and filtered out. The products were crystallized from dimethyl formamide and dried under vacuum.
  • 41
  • [ 7012-88-6 ]
  • [ 459-57-4 ]
  • 7-chloro-2-[(E)-2-(4-fluorophenyl)ethenyl]quinazolin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With sulfuric acid; at 190℃; under 750.075 - 5250.53 Torr; for 1.5h;Microwave irradiation; General procedure: The 2-methylquinazolin-4(3H)-ones (1 mmol) were mixed with benzaldehydes (1.5 mmol) and 1 drop concentrated sulphuric acid was added to the mixtures. The reaction was carried out in microwave set (Personal Chemistry, Emrys Creator, heating power: 150 W, measured pressure 1-7 bar, reaction time: 1.5 hours) at 190 C. The crude product was washed with 5% sodium hydrogen carbonate and filtered out. The products were crystallized from dimethyl formamide and dried under vacuum.
  • 42
  • [ 7012-88-6 ]
  • N'-{7-chloro-2-[(E)-2-(4-fluorophenyl)ethenyl]quinazolin-4-yl}-N,N-diethylpropane-1,3-diamine [ No CAS ]
  • 43
  • [ 7012-88-6 ]
  • 7-chloro-2-[(E)-2-(4-fluorophenyl)ethenyl]-N-(3-morpholin-4-ylpropyl)quinazolin-4-amine [ No CAS ]
  • 44
  • [ 7012-88-6 ]
  • 7-chloro-2-[(E)-2-(4-fluorophenyl)ethenyl]-N-[3-(4-methylpiperazin-1-yl)propyl]quinazolin-4-amine [ No CAS ]
  • 45
  • [ 7012-88-6 ]
  • N'-{6-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4-yl}-N,N-dimethylpropane-1,3-diamine [ No CAS ]
  • 46
  • [ 7012-88-6 ]
  • N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4-yl}propane-1,3-diamine [ No CAS ]
  • 47
  • [ 7012-88-6 ]
  • 6-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]-N-(3-morpholin-4-ylpropyl)quinazolin-4-amine [ No CAS ]
  • 48
  • [ 7012-88-6 ]
  • 4,7-dichloro-2-[(E)-2-(4-fluorophenyl)ethenyl]quinazoline [ No CAS ]
  • 49
  • [ 7012-88-6 ]
  • 4-chloro-6-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazoline [ No CAS ]
  • 50
  • [ 1397833-65-6 ]
  • [ 78-39-7 ]
  • [ 7012-88-6 ]
YieldReaction ConditionsOperation in experiment
68% With ammonium acetate; In 1,4-dioxane;Reflux; General procedure: N -(2-aminobenzoyl)benzotriazoles (0.25 mmol) 1 previously synthesized by our group were reacted with orthoester (0.50 mmol) 2 and ammonium acetate (1.0 mmol) in dioxane for 6-10 h. After completion of the reaction, the solvent was evaporated under reduced pressure. The reaction mixture was purified by column chromatography over silica gel with a EtOAc/n-hexane mixture (from 1:2 or 1:1) to obtain white crystals (62%-95%).
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Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Additions of Organometallic Reagents • Acetal Formation • Acid-Catalyzed α -Halogenation of Ketones • Acyl Group Substitution • Add Hydrogen Cyanide to Aldehydes and Ketones to Produce Alcohols • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohol Syntheses from Aldehydes, Ketones and Organometallics • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Aldehydes and Ketones Form Hemiacetals Reversibly • Aldehydes May Made by Terminal Alkynes Though Hydroboration-oxidation • Aldol Addition • Aldol Condensation • Alkenes React with Ozone to Produce Carbonyl Compounds • Alkyl Halide Occurrence • Alkylation of Aldehydes or Ketones • Alkylation of an Alkynyl Anion • Alkylation of Enolate Ions • Amide Hydrolysis • Amide Hydrolysis • Amides Can Be Converted into Aldehydes • Amines Convert Acyl Chlorides into Amides • An Alkane are Prepared from an Haloalkane • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Base-Catalyzed Hydration of α,β -Unsaturated Aldehydes and Ketones • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Chloroalkane Synthesis with SOCI2 • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Clemmensen Reduction • Complex Metal Hydride Reductions • Conjugated Enone Takes Part in 1,4-Additions • Convert Haloalkanes into Alcohols by SN2 • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Cyanohydrins can be Convert to Carbonyl Compounds under Basic Conditions • Decarboxylation of 3-Ketoacids Yields Ketones • Decarboxylation of Substituted Propanedioic • Deoxygenation of the Carbonyl Group • Deprotonation of a Carbonyl Compound at the α -Carbon • Diorganocuprates Convert Acyl Chlorides into Ketones • Dithioacetal Formation • Enamines Can Be Used to Prepare Alkylated Aldehydes • Enol-Keto Equilibration • Enolate Ions Are Protonated to Form ketones • Exclusive 1,4-Addition of a Lithium Organocuprate • Fischer Indole Synthesis • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Friedel-Crafts Alkylation of Benzene with Haloalkanes • Furan Hydrolyzes to Dicarbonyl Compounds • Geminal Diols and Acetals Can Be Hydrolyzed to Carbonyl Compounds • General Reactivity • Grignard Reaction • Halogenation of Alkenes • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Henry Nitroaldol Reaction • HIO4 Oxidatively Degrades Vicinal Diols to Give Carbonyl Derivatives • Hiyama Cross-Coupling Reaction • Hofmann Rearrangement • Horner-Wadsworth-Emmons Reaction • Hydration of the Carbonyl Group • Hydride Reductions • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydrogenation by Palladium on Carbon Gives the Saturated Carbonyl Compound • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Isomerization of β, γ -Unsaturated Carbonyl Compounds • Ketone Synthesis from Nitriles • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • Lithium Organocuprate may Add to the α ,β -Unsaturated Carbonyl Function in 1,4-Fashion • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mercury Ions Catalyze Alkynes to Ketones • Methylation of Ammonia • Michael Addition • Oxidation of Alcohols to Carbonyl Compounds • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Phenylhydrazone and Phenylosazone Formation • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Pyrroles, Furans, and Thiophenes are Prepared from γ-Dicarbonyl Compounds • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reductive Amination • Reductive Amination • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Strecker Synthesis • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Reaction of Alkynyl Anions with Carbonyl Derivatives • The Wittig Reaction • Thiazolium Salt Catalysis in Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Ugi Reaction • Use 1,3-dithiane to Prepare of α-Hydroxyketones • Wittig Reaction • Wolff-Kishner Reduction
Historical Records

Related Functional Groups of
[ 7012-88-6 ]

Chlorides

Chemical Structure| 7142-09-8

[ 7142-09-8 ]

6-Chloro-2-methylquinazolin-4(3H)-one

Similarity: 0.99

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Related Parent Nucleus of
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; ;