[ CAS No. 7031-27-8 ] {[proInfo.proName]}

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Quality Control of [ 7031-27-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 7031-27-8 ]

CAS No. :	7031-27-8	MDL No. :	MFCD00054471
Formula :	C₈H₇ClOS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	186.65	Pubchem ID :	-
Synonyms :

Safety of [ 7031-27-8 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P260-P264-P280-P305+P351+P338-P405-P501	UN#:	3265
Hazard Statements:	H314	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 7031-27-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7031-27-8 ]

[ 7031-27-8 ] Synthesis Path-Downstream 1~20

1
[ 103-04-8 ]
[ 7031-27-8 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1998,vol. 37,p. 1114 - 1119
[2]Synthesis,1985,p. 276 - 279
[3]Journal of the Chemical Society. Perkin transactions I,1991,p. 2499 - 2504
[4]Tetrahedron,1987,vol. 43,p. 2045 - 2058
[5]Journal of Medicinal Chemistry,1986,vol. 29,p. 2465 - 2472
[6]Journal of medicinal chemistry,1971,vol. 14,p. 1004 - 1005
[7]Journal of Medicinal Chemistry,1993,vol. 36,p. 3397 - 3408
[8]Journal of Medicinal Chemistry,1993,vol. 36,p. 3224 - 3229
[9]Il Farmaco,1997,vol. 52,p. 685 - 689
[10]Acta Crystallographica, Section C: Crystal Structure Communications,1998,vol. 54,p. 488 - 489
[11]Bioorganic and Medicinal Chemistry,2000,vol. 8,p. 2317 - 2335
[12]Il Farmaco,2001,vol. 56,p. 169 - 174
[13]Chemical and Pharmaceutical Bulletin,2001,vol. 49,p. 1132 - 1137
[14]Journal of the American Chemical Society,2001,vol. 123,p. 4966 - 4973
[15]European Journal of Medicinal Chemistry,2007,vol. 42,p. 1293 - 1299
[16]Russian Chemical Bulletin,2007,vol. 56,p. 130 - 136
[17]Australian Journal of Chemistry,2008,vol. 61,p. 881 - 887
[18]ChemMedChem,2014,vol. 9,p. 657 - 664
[19]Journal of Medicinal Chemistry,2014,vol. 57,p. 2380 - 2392
[20]Angewandte Chemie - International Edition,2015,vol. 54,p. 8791 - 8794
Angew. Chem.,2015,vol. 127,p. 8915 - 8918,4
[21]Chemistry - A European Journal,2014,vol. 20,p. 13984 - 13992
[22]New Journal of Chemistry,2016,vol. 40,p. 6200 - 6213
[23]Patent: JP2016/17040,2016,A .Location in patent: Paragraph 0025; 0028
[24]Journal of the American Chemical Society,2016,vol. 138,p. 12219 - 12227
[25]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6267 - 6272
[26]Chemical Communications,2020,vol. 56,p. 5649 - 5652
[27]Chemistry - A European Journal,2020,vol. 26,p. 10712 - 10718

2
[ 7031-27-8 ]
[ 364-62-5 ]
[ 65569-59-7 ]

Yield	Reaction Conditions	Operation in experiment
44.6%	With triethylamine In toluene for 6h; Heating;

Reference： [1]Metz; Pindell; Chen [Journal of Medicinal Chemistry, 1983, vol. 26, # 7, p. 1065 - 1070]

3
[ 7031-27-8 ]
[ 137469-70-6 ]
[ 137469-79-5 ]

Yield	Reaction Conditions	Operation in experiment
93%	With triethylamine In dichloromethane for 1h; Ambient temperature;

Reference： [1]Kennedy, Michael G.; Moody, Christopher J.; Rees, Charles W.; Thomas, Robert [Journal of the Chemical Society. Perkin transactions I, 1991, # 10, p. 2499 - 2504]

4
[ 7031-27-8 ]
[ 71-43-2 ]
[ 130-03-0 ]
[ 16222-10-9 ]

Reference： [1]Synthetic Communications,1989,vol. 19,p. 443 - 452

5
[ 7031-27-8 ]
[ 108-16-7 ]
[ 35859-03-1 ]

Reference： [1]Journal of medicinal chemistry,1971,vol. 14,p. 1004 - 1005

6
[ 7031-27-8 ]
[ 4931-66-2 ]
[ 229640-35-1 ]

Yield	Reaction Conditions	Operation in experiment
87%	In benzene at 80℃;
19.7 g	In benzene for 24h; Heating;
	In benzene Reflux;

Reference： [1]Straub; Padwa [Organic letters, 1999, vol. 1, # 1, p. 83 - 85]
[2]Padwa, Albert; Sheehan, Scott M.; Straub, Christopher S. [Journal of Organic Chemistry, 1999, vol. 64, # 23, p. 8648 - 8659]
[3]Location in patent: scheme or table Haffner, Curt D.; Diaz, Caroline J.; Miller, Aaron B.; Reid, Robert A.; Madauss, Kevin P.; Hassell, Annie; Hanlon, Mary H.; Porter, David J.T.; Becherer, J. David; Carter, Luke H. [Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 15, p. 4360 - 4363]

7
[ 7031-27-8 ]
[ 130-03-0 ]

Yield	Reaction Conditions	Operation in experiment
63%	With indium(III) tosylate; In dodecane; nitromethane; for 2h;Schlenk technique; Reflux;	General procedure: Into a Schlenk flask were introduced 20 mL of nitromethane,2 mmol of 1,3-dimethoxybenzene, 10 mol % of catalyst and4 mmol of acetyl chloride, with 0.5 mmol of dodecane for GC monitoring. The solutions were heated at reflux. The reactionswere followed by gas chromatography, by analysis of aliquots.The products were obtained after extraction by diethyl ether andpurification by column chromatography. All products are knowncompounds.

Reference： [1]Journal of Chemical Research, Miniprint,1999,p. 2401 - 2420
[2]Tetrahedron,2015,vol. 71,p. 6813 - 6817
[3]Chemistry - A European Journal,2014,vol. 20,p. 13984 - 13992
[4]Journal of the American Chemical Society,2016,vol. 138,p. 12219 - 12227

8
[ 7031-27-8 ]
[ 129-44-2 ]
<i>N</i>-[9,10-dioxo-5-(2-phenylsulfanyl-acetylamino)-9,10-dihydro-anthracen-1-yl]-2-phenylsulfanyl-acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With pyridine In N,N-dimethyl-formamide at 20℃; for 24h;

Reference： [1]Huang, Hsu-Shan; Chiu, Hui-Fen; Tao, Chi-Wei; Chen, In-Been [Chemical and Pharmaceutical Bulletin, 2006, vol. 54, # 4, p. 458 - 464]

9
[ 7031-27-8 ]
[ 865706-98-5 ]
[ 865706-99-6 ]

Yield	Reaction Conditions	Operation in experiment
49%	Stage #1: (phenylthio)acetic acid chloride; methyl (E)-2-amino-2-(hydroxyimino)acetate In tetrahydrofuran at 20℃; for 1h; Stage #2: In 1,4-dioxane Heating / reflux;	82.2 300 mg (2.54 mmol) of amino-hydroxyimino-acetic acid methyl ester and 428 mg (2.29 mmol, 0.9 eq) of phenylsulfanyl-acetyl chloride were stirred in 10 mL of THF at RT for 1 hour. The solvent was evaporated, the residue dissolved in dioxane, and the reaction mixture was heated at reflux over night in the presence of molecular sieves. Filtration, concentration under vacuum and column chromatography over silica gel with EtOAc/heptane 1: 1 yielded 310 mg (49%) of 5-phenylsulfanylmethyl- [1, 2,4] oxadiazole-3- carboxylic acid methyl ester as light yellow oil, MS: 268 (MNH4+).

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2005/92856, 2005, A1 Location in patent: Page/Page column 85

10
[ 26214-65-3 ]
[ 7031-27-8 ]
(S)-3-(2,5-dimethoxyphenacyl)-5-hydroxymethyl-2-oxazolidinone [ No CAS ]
[ 38870-89-2 ]
[ 2251-50-5 ]
[ 39637-99-5 ]
[ 10313-60-7 ]
[ 4023-34-1 ]
[ 53064-54-3 ]
[ 5538-51-2 ]
[ 157373-08-5 ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(2-methoxyacetyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(cyclopropanecarbonyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(furan-3-carbonyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(isoxazole-3-carbonyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(2-(phenylthio)acetyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(3,4-dimethoxybenzoyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(2-acetoxybenzoyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(2,3,4-trifluorobenzoyloxy)methyl-2-oxazolidinone [ No CAS ]
(S)-3-(2,5-dimethoxyphenacyl)-5-(perfluorobenzoyloxy)methyl-2-oxazolidinone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In pyridine; dichloromethane at 20℃; Combinatorial reaction / High throughput screening (HTS);	3 To about 295 mg (1.0 mmoles) of (S)-3- (2,5-dimethocyphenacyl) -5- hydroxymethyl-2-oxazolidinone in dry CH2Cl2 (8 mL CH2Cl2), 1.0 equiv. (1.1 mmoles) of pyridine was added and the reaction mixture stirred at room temperature. To this reaction mixture was added 1.0 equiv. of a mixture of ten different acetyl chlorides. The reaction was stirred overnight at room temperature. Afterwards, TLC of an aliquot indicated that complete conversion of the (S)-3- (2,5-dimethocyphenacyl) -5- hydroxymethyl-2-oxazolidinone to (S)-3- (2,5- dimethocyphenacyl)-5- (substituted methyl) -2- oxazolidinone had occurred. Therefore, about 3 mL of 20% NH4Cl was added to the reaction mixture and the organic layer removed and saved. The aqueous layer was extracted two times with 40 mL aliquots of CH2Cl2. The CH2Cl2 extracts were combined with the saved organic layer and the mixture dried with 2.5 g anhydrous Na2SO4. The mixture was then concentrated in vacuo to provide a crude product. The crude product was analyzed by 1H-NMR, 13C NMR, HPLC, and TLC using a EtOAc: hexane (2: 1) solvent system. An HPLC profile of the (S)-3- (2,5- dimethocyphenacyl)-5- (substituted methyl) -2- oxazolidinone products made is shown in Figure 3. The products represented by the peaks in the HPLC are shown in Figure 4. This example illustrates the principle of the present invention. As shown by this example, providing n=10 acetyl halides in a single reaction produces 10 (S)-3- (2,5-dimethocyphenacyl) -5- (substituted methyl) -2-oxazolidinone products. If n=10 aryl bromides had been used as well to arylate the N at the 3-position, the process would have generated 100 (S)-3- (substituted)-5- (substituted methyl) -2-oxazolidinone products.

Reference： [1]Current Patent Assignee: MICHIGAN STATE UNIVERSITY - WO2003/106413, 2003, A2 Location in patent: Page 50; 51

11
[ 180-48-3 ]
[ 7031-27-8 ]
[ 1174046-91-3 ]

Yield	Reaction Conditions	Operation in experiment
	With solid phase supported DIEA In dichloromethane at 20℃;

Reference： [1]Location in patent: scheme or table Rodriguez, Alice L.; Williams, Richard; Zhou, Ya; Lindsley, Stacey R.; Le, Uyen; Grier, Mark D.; David Weaver; Jeffrey Conn; Lindsley, Craig W. [Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 12, p. 3209 - 3213]

12
[ 7031-27-8 ]
[ 3177-80-8 ]
[ 1265087-51-1 ]

Yield	Reaction Conditions	Operation in experiment
85%		General procedure: A mixture of substituted anthranilic acids 4a-f (30 mmol), NaOH (60 mmol) and phenylthioacetyl chloride (30 mmol) in H2O (20 mL) was stirred at 0 C for 1 h, and then at rt for 2 h. The mixture was acidified with 5% HCl (pH 4-5) and then extracted with EtOAc (2 × 500 mL). The combined organic layer was dried over Na2SO4, filtered, and solvent was evaporated in vacuo. The residue obtained was recrystallized using EtOAc/hexane (3:1) to give compounds 6a-f as white solids.

Reference： [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 458 - 470

13
[ 7031-27-8 ]
[ 6388-47-2 ]
[ 1265087-56-6 ]

Yield	Reaction Conditions	Operation in experiment
86%		General procedure: A mixture of substituted anthranilic acids 4a-f (30 mmol), NaOH (60 mmol) and phenylthioacetyl chloride (30 mmol) in H2O (20 mL) was stirred at 0 C for 1 h, and then at rt for 2 h. The mixture was acidified with 5% HCl (pH 4-5) and then extracted with EtOAc (2 × 500 mL). The combined organic layer was dried over Na2SO4, filtered, and solvent was evaporated in vacuo. The residue obtained was recrystallized using EtOAc/hexane (3:1) to give compounds 6a-f as white solids.

Reference： [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 458 - 470

14
[ 7031-27-8 ]
[ 53600-33-2 ]
[ 1265087-47-5 ]

Yield	Reaction Conditions	Operation in experiment
67%		General procedure: A mixture of substituted anthranilic acids 4a-f (30 mmol), NaOH (60 mmol) and phenylthioacetyl chloride (30 mmol) in H2O (20 mL) was stirred at 0 C for 1 h, and then at rt for 2 h. The mixture was acidified with 5% HCl (pH 4-5) and then extracted with EtOAc (2 × 500 mL). The combined organic layer was dried over Na2SO4, filtered, and solvent was evaporated in vacuo. The residue obtained was recrystallized using EtOAc/hexane (3:1) to give compounds 6a-f as white solids.

Reference： [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 458 - 470

15
[ 7031-27-8 ]
[ 2148-56-3 ]
[ 1265087-53-3 ]

Yield	Reaction Conditions	Operation in experiment
82%		General procedure: A mixture of substituted anthranilic acids 4a-f (30 mmol), NaOH (60 mmol) and phenylthioacetyl chloride (30 mmol) in H2O (20 mL) was stirred at 0 C for 1 h, and then at rt for 2 h. The mixture was acidified with 5% HCl (pH 4-5) and then extracted with EtOAc (2 × 500 mL). The combined organic layer was dried over Na2SO4, filtered, and solvent was evaporated in vacuo. The residue obtained was recrystallized using EtOAc/hexane (3:1) to give compounds 6a-f as white solids.

Reference： [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 458 - 470

16
[ 7031-27-8 ]
[ 5653-40-7 ]
[ 693234-26-3 ]

Yield	Reaction Conditions	Operation in experiment
79.75%	With pyridine at 20℃; for 3h;	General Procedure for the Synthesis of 2-(2-(Benzyloxy orPhenylthio) acetamido)-4,5-dimethoxybenzoic Acid (4-5) General procedure: 2-(Benzyloxy or phenylthio) acetyl chlorides (2-3) (0.05mol) were added to a solution of anthranilic acid (1) (0.05mol) in pyridine (50 mL) and the reaction mixture wasstirred at room temperature for 3 h. The mixture was thenpoured into 10% cold dilute hydrochloric acid solution (50mL). The solid obtained was then filtered followed by washingseveral times with cold water. The product 2-(2-(benzyloxy or phenylthio) acetamido)-4,5-dimethoxybenzoicacids (4-5) was dried and crystallized from absolute ethanol.

Reference： [1]Das, Nirupam; Banerjee, Anupam G.; Shrivastava, Sushant K. [Medicinal Chemistry, 2014, vol. 10, # 8, p. 800 - 809]

17
[ 7031-27-8 ]
[ 1446-61-3 ]
C₂₈H₃₇NOS [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With triethylamine; In dichloromethane; at 0 - 23℃;	To a solution of <strong>[1446-61-3](+)-dehydroabietylamine</strong>(1.0mmol) and triethylamine (3.0 mmol) in CH2Cl2 (5 mL), a solution of the corresponding acyl chloride (1.10 mmol) in CH2Cl2 (5 mL) was slowly added dropwise via syringe at 0 C. Theresulting reaction mixture was allowed to be warmed and was stirred at 23 C for 1-12 hr based on the reaction?s progress (TLC, MS) before it was quenche dwith an aqueous NH4Cl solution (10 mL). The organic phase was separated and the aqueous phase was extracted with CH2Cl2 (5mL x 3). The combined organic phase was dried over MgSO4 and concentrated under reduced pressure. The resulting crude product was purified via flash columnchromatography (SiO2; isocratic eluent: 20% EtOAc in petroleum ether) to provide the amide product.

Reference： [1]European Journal of Medicinal Chemistry,2015,vol. 102,p. 9 - 13

18
[ 7031-27-8 ]
[ 1219025-18-9 ]
[ 1809609-55-9 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;

Reference： [1]Bao, Deng-Hui; Wu, Hui-Ling; Liu, Chao-Lun; Xie, Jian-Hua; Zhou, Qi-Lin [Angewandte Chemie - International Edition, 2015, vol. 54, # 30, p. 8791 - 8794][Angew. Chem., 2015, vol. 127, # 30, p. 8915 - 8918,4]

19
[ 7031-27-8 ]
[ 29909-46-4 ]
S-3-(2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecan-1-yl)propyl 2-(phenylthio)ethanethioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: (phenylthio)acetic acid chloride With triethylamine In chloroform at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 1-(γ-mercaptopropyl)silatrane In chloroform for 4h; Inert atmosphere; Reflux;

Reference： [1]Singh, Gurjaspreet; Rani, Sunita; Arora, Aanchal; Aulakh, Darpandeep; Wriedt, Mario [New Journal of Chemistry, 2016, vol. 40, # 7, p. 6200 - 6213]

20
[ 17647-70-0 ]
[ 7031-27-8 ]
N-(4-methyl-1,2,5-oxadiazol-3-yl)-2-(phenylthio)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
243 g	In dichloromethane Reflux;	General procedure: To a solution of phosphorus pentachloride (0.126 g, 0.610 mmol) in dichloromethane (11 mL), phenoxyacetic acid (0.092 g, 0.610 mmol) was added with stirring and the mixture refluxed for 30-40 minutes. After cooling, 4-methyl-1,2,5-oxadiazol-3-amine (0.060 g, 0.610 mmol) was added and the solution refluxed for 2-2.5 hours. The solvent was removed under reduced pressure and the residue quenched with water (50 mL). The solid was collected by vacuum filtration and washed with saturated sodium bicarbonate solution followed by water to afford compound 19 (0.103 g, 73%)

Reference： [1]Christoff, Rebecca M.; Murray, Gerald L.; Kostoulias, Xenia P.; Peleg, Anton Y.; Abbott, Belinda M. [Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6267 - 6272]

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P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 7031-27-8 ] {[proInfo.proName]}

Quality Control of [ 7031-27-8 ]

Related Doc. of [ 7031-27-8 ]

Product Details of [ 7031-27-8 ]

Safety of [ 7031-27-8 ]

Application In Synthesis of [ 7031-27-8 ]

[ 7031-27-8 ] Synthesis Path-Downstream 1~20

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry