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Chemical Structure| 708279-23-6 Chemical Structure| 708279-23-6

Structure of 708279-23-6

Chemical Structure| 708279-23-6

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Product Details of [ 708279-23-6 ]

CAS No. :708279-23-6
Formula : C13H18N4O3
M.W : 278.31
SMILES Code : O=C(NC1=CC=C([N+]([O-])=O)C=C1)CN2CCN(C)CC2

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Application In Synthesis of [ 708279-23-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 708279-23-6 ]

[ 708279-23-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-01-3 ]
  • [ 17329-87-2 ]
  • [ 708279-23-6 ]
YieldReaction ConditionsOperation in experiment
79% In isopropyl alcohol; at 80℃; for 17h;Inert atmosphere; [00401] Step 1 : A mixture of 2-chloro-N-(4-nitrophenyl)acetamide (500 mg, 2.33 mmol) and N-methylpiperazine (2.6 mL, 23 mmol) in isopropanol (ca. 5 mL) was stirred at 80 C for ca. 17h. The mixture was partitioned between EtOAc and and aq. NaHC03 (ca. 10 mL each; 50% NaHC03 saturation), and the organic layer was separated and dried over anhydrous Na2S04 to afford the desired product as a yellow solid (513 mg, 79% yield). 1H NMR (DMSO-d6, 400 MHz) δ 10.32 (br s, 1H), 8.23-8.21 (m, 2H), 7.91-7.89 (m, 2H), 3.31 (s, 2H), 2.51 (br s, 4H), 2.33 (br s, 4H), 2.17 (s, 3H); MS (ESI): calcd for C13H18N403 : 278, found: 279 (MH+).
 

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