Home Cart Sign in  
Chemical Structure| 717133-25-0 Chemical Structure| 717133-25-0

Structure of 717133-25-0

Chemical Structure| 717133-25-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 717133-25-0 ]

CAS No. :717133-25-0
Formula : C20H24ClFN2O2
M.W : 378.87
SMILES Code : N#CC1=CC=C(C(O)(C2=CC=C(F)C=C2)CCCN(C)C)C(CO)=C1.[H]Cl
MDL No. :MFCD10000612

Safety of [ 717133-25-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319-H317
Precautionary Statements:P305+P351+P338-P280

Application In Synthesis of [ 717133-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 717133-25-0 ]

[ 717133-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19070-16-7 ]
  • [ 82104-74-3 ]
  • [ 352-13-6 ]
  • [ 717133-25-0 ]
YieldReaction ConditionsOperation in experiment
5-cyanophthalide (31.8 g, 1.0 equiv.), tetrahydrofuran (300 ml), and a certain amount of metal salt MAXB were added. The reactants were cooled to ?5° C., and the reaction was carried out under stirring for 0.5 hour. At a temperature controlled at ?5 to 0° C., 300 ml of a solution of p-fluorophenyl magnesium bromide in tetrahydrofuran (0.8 mmol/ml, 1.2 equiv.) was slowly added dropwise. After the addition, the reaction was carried out under stirring for 1 hour while maintaining the temperature. The temperature was raised to 5° C. and controlled between 5 to 10° C. 260 ml solution of N,N-dimethylaminopropyl magnesium chloride in tetrahydrofuran (1.0 mmol/ml, 1.3 equivalent) was slowly added dropwise. After the addition, the reaction was carried out under stirring for 0.5 hour while maintaining the temperature. The reaction solution was added into 500 mL of saturated aqueous solution of ammonium chloride, and stirred for 2 hours. The organic layer was separated. The aqueous layer was extracted twice with toluene 200 ml×2. The organic layers were combined, washed twice with water 200 ml×2, and concentrated to dry. A sample was taken and tested with HPLC for the conversion rate of the reaction and the purity of the main product in the reaction solution. 400 ml of toluene was added to the dry product. The mixture was heated to 50° C., and stirred till clear. 100 ml of water was added to the mixture. The aqueous layer was adjusted with concentrated hydrochloric acid to a pH of 4.0-5.0, and separated. The toluene layer was further extracted once with 50 ml of water. The aqueous layers were combined, and cooled to 5° C. A large amount of solid was precipitated. The mixture was stirred for 60 minutes while maintaining the temperature, and filtered. The filter cake was dried under vacuum at 50° C. to give citalopram diol hydrochloride. The yield was calculated. Different equivalents and types of metal salt MAXB, and different organic solvents are used for performing the above experiment. The results are shown in the following table:
 

Historical Records

Technical Information

Categories