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Chemical Structure| 71800-49-2 Chemical Structure| 71800-49-2

Structure of 71800-49-2

Chemical Structure| 71800-49-2

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Product Details of [ 71800-49-2 ]

CAS No. :71800-49-2
Formula : C12H15NO4
M.W : 237.25
SMILES Code : OC1=CC=C(C[C@@H](C(OCC)=O)NC=O)C=C1

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Application In Synthesis of [ 71800-49-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71800-49-2 ]

[ 71800-49-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 64-18-6 ]
  • [ 4089-07-0 ]
  • [ 71800-49-2 ]
YieldReaction ConditionsOperation in experiment
82% With tetraethoxy orthosilicate; triethylamine; In acetonitrile; at 25℃;Inert atmosphere; General procedure: To a stirred solution of a corresponding aminoacid ethyl ester hydrochlorides (2a-i, 0.5 mmol) and triethylamine (132 mL, 1.5 mmol) in dry CH3CN (1 mL) were added formic acid (56 mL, 1.5 mmol) and Si(OEt)4 (1.0 mL, 4.5 mmol) at 25 °C under nitrogen atmosphere. After stirring for 17-23 h at room temperature, the reaction mixture was transferred to separatory funnel containing n-hexane (20 mL) with 50percent v/v aqueous MeOH (6 mL). After separation of aqueous MeOH layer, hexane layer was extracted two times with 50percent v/v aqueous MeOH (6 mL each). The combined aqueous MeOH layer was diluted with EtOAc (30 mL). The organic layer was washed sequentially with 1 M aqueous solution of KHSO4, saturated aqueous NaHCO3 and brine. The resulting organic layer was dried over Na2SO4 and concentrated at reduced pressure to give the crude product, which was purified by silica gel chromatography to give the title compound (3a-j).
 

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