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Chemical Structure| 71916-82-0 Chemical Structure| 71916-82-0

Structure of 71916-82-0

Chemical Structure| 71916-82-0

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Product Details of [ 71916-82-0 ]

CAS No. :71916-82-0
Formula : C7H5BrClF
M.W : 223.47
SMILES Code : FC1=CC(Cl)=CC=C1CBr
MDL No. :MFCD00831105
InChI Key :UFCSSWZQROEFBZ-UHFFFAOYSA-N
Pubchem ID :2736551

Safety of [ 71916-82-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H290-H314
Precautionary Statements:P210-P234-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P403+P235-P405-P406-P501
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 71916-82-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71916-82-0 ]

[ 71916-82-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 56456-49-6 ]
  • [ 71916-82-0 ]
YieldReaction ConditionsOperation in experiment
54% With phosphorus tribromide; In diethyl ether; at 0 - 20℃; for 3h; To a stirred solution of alcohol (0.8 g, 5.0 mol) in dry Et2O (10 mL) was added phosphorus tribromide (PBr3; 0.33 mL, 3.5 mmol) at 0 C. The reaction mixture was stirred at RT for 3 h. After consumption of the starting material (by TLC), the reaction mixture was quenched with ice pieces, and the aqueous layer was extracted with EtOAc (2×75 mL). The combined organic layers were washed with satd NaHCO3 solution, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 1-(bromomethyl)-4-chloro-2-fluorobenzene (0.6 g, 2.7 mmol, 54%) as a light yellow liquid. 1H NMR (200 MHz, CDCl3): delta 7.41 (q, J=14.5, 16.6 Hz, 1H), 7.15-7.07 (m, 2H), 4.46 (s, 2H).
  • 2
  • [ 119838-38-9 ]
  • [ 71916-82-0 ]
  • [ 185826-38-4 ]
 

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