[ CAS No. 7210-73-3 ] {[proInfo.proName]}

Name: 7210-73-3|Ethyl 4-methylthiazole-2-carboxylate|98%
Brand: Ambeed
SKU: A546209
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2D 3D

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Quality Control of [ 7210-73-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 7210-73-3 ]

SDS Specification

Alternatived Products of [ 7210-73-3 ]

Product Details of [ 7210-73-3 ]

CAS No. :	7210-73-3	MDL No. :	MFCD11112113
Formula :	C₇H₉NO₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	YJWKNFZGGQBYGD-UHFFFAOYSA-N
M.W :	171.22	Pubchem ID :	567306
Synonyms :

Calculated chemistry of [ 7210-73-3 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.43
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	43.17
TPSA :	67.43 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.99 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.27
Log Po/w (XLOGP3) :	1.91
Log Po/w (WLOGP) :	1.63
Log Po/w (MLOGP) :	0.37
Log Po/w (SILICOS-IT) :	2.64
Consensus Log Po/w :	1.76

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.24
Solubility :	0.978 mg/ml ; 0.00571 mol/l
Class :	Soluble
Log S (Ali) :	-2.95
Solubility :	0.192 mg/ml ; 0.00112 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.16
Solubility :	1.19 mg/ml ; 0.00697 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.46

Safety of [ 7210-73-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 7210-73-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 7210-73-3 ]
Downstream synthetic route of [ 7210-73-3 ]

[ 7210-73-3 ] Synthesis Path-Upstream 1~2

1
[ 7210-73-3 ]
[ 14542-15-5 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2335 - 2339

2
[ 7210-73-3 ]
[ 14542-16-6 ]

Yield	Reaction Conditions	Operation in experiment
52%	With lithium hydroxide In tetrahydrofuran; methanol; water at 20℃; for 1 h;	To asolution of ethyl 4-methylthiazole-2-carboxylate 8a (884 mg, 5.16 mmol) in a mixture of H₂O/MEOH/THF= 1:1:1 (12 mL) was added LiOH (310 mg, 13.0 mmol). The solution was stirred at room temperature for 1 hour. The resulting mixture was diluted by water and washed with ethyl acetate. The aqueous phase was adjusted pH to 3 by slowly adding HCl 1M and extracted with ethyl acetate. The combined organic layer was dried over MgSO₄ and concentrated under reduced pressure to give 4-methylthiazole-2-carboxylic acid 9 (384 mg, 52percent) without further purification: ¹H-NMR (400 MHz, CD₃OD) δ 7.48 (s, 1H), 2.47 (d, J = 0.92,1H).

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 140 - 144
[2] Helvetica Chimica Acta, 1944, vol. 27, p. 1437
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2335 - 2339

[ 7210-73-3 ] Synthesis Path-Downstream 1~39

1
[ 7210-73-3 ]
[ 14542-16-6 ]

Yield	Reaction Conditions	Operation in experiment
52%	With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20℃; for 1h;	To asolution of ethyl 4-methylthiazole-2-carboxylate 8a (884 mg, 5.16 mmol) in a mixture of H2O/MEOH/THF= 1:1:1 (12 mL) was added LiOH (310 mg, 13.0 mmol). The solution was stirred at room temperature for 1 hour. The resulting mixture was diluted by water and washed with ethyl acetate. The aqueous phase was adjusted pH to 3 by slowly adding HCl 1M and extracted with ethyl acetate. The combined organic layer was dried over MgSO4 and concentrated under reduced pressure to give 4-methylthiazole-2-carboxylic acid 9 (384 mg, 52%) without further purification: 1H-NMR (400 MHz, CD3OD) delta 7.48 (s, 1H), 2.47 (d, J = 0.92,1H).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,p. 140 - 144
[2]Helvetica Chimica Acta,1944,vol. 27,p. 1437
[3]Journal of the Chemical Society. Perkin transactions I,1981,p. 2335 - 2339

2
[ 7210-73-3 ]
[ 760201-86-3 ]

Reference： [1]Helvetica Chimica Acta,1944,vol. 27,p. 1437

3
[ 7210-73-3 ]
[ 100516-76-5 ]

Yield	Reaction Conditions	Operation in experiment
57%	With hydrazine hydrate; In ethanol; for 18.0h;Reflux;	Scheme 9: Synthesis of 4-methylthiazole-2-carbohydrazide 2kIn a 100 mL round-bottom flask equipped with a condenser, 4-methylthiazole-2-carboxylate 2.2k (500 mg, 2.92 mmol, 1 eq.) was dissolved in anhydrous EtOH (5 mL) and treated at RT with hydrazine monohydrate (216 mu?, 4.46 mmol, 1.5 eq.). The resulting solution was heated at reflux temperature for 18 hours. After allowing the reaction mixture to come to RT, the solution was concentrated under reduced pressure and the obtained crude was purified on a pad of silica (eluent: DCM/MeOH: 100/0 to 97/3) to afford 266 mg of 2kas a white solid (266 mg, 1.69 mmol, 57 %). LCMS: P = 90 %, retention time = 0.7 min, (M+H)+: 158.
	With hydrazine; In ethanol; at 20℃;Reflux;	A solution of ethyl 4-methyl-1 ,3-thiazole-2-carboxylate (1120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg. LCMS m/z 157.92 [M+H] (at) 0.41 min (2 min run).

Reference： [1]Patent: WO2013/50424,2013,A1 .Location in patent: Page/Page column 114
[2]Journal of medicinal and pharmaceutical chemistry,1959,vol. 1,p. 577,594
[3]Patent: WO2010/125102,2010,A1 .Location in patent: Page/Page column 120

4
[ 16982-21-1 ]
[ 78-95-5 ]
[ 7210-73-3 ]

Yield	Reaction Conditions	Operation in experiment
81%	In acetonitrile; for 18.0h;Inert atmosphere; Reflux;	To a solution of ethyl 2-amino-2-thiooxamate (0.666 g, 5.00 mmol) in CH3CN (15 mL) was added 1-chloropropan-2-one (1.50 mL, 18.0 mL). The mixture solution was stirred for 18 h under refluxing conditions. After being cooled to room temperature, the reaction mixture was concentrated in vacuo, and was subjected to column chromatography on SiO2 (hexane : EtOAc = 2 : 1) to give ethyl 4-methylthiazole-2-carboxylate (0.694 g, 4.05 mmol, 81%) as yellow liquid: 1H NMR (300 MHz, CDCl3) delta 1.44 (t, J = 7.2 Hz, 3H), 2.56 (d, J = 0.8 Hz, 3H), 4.49 (q, J = 7.2 Hz, 2H), 7.20 (q, J = 0.7 Hz, 1H); 13C NMR (75 MHz, CDCl3) delta 14.2, 17.1, 62.4, 120.1, 155.3, 157.5, 160.0; IR (NaCl plate) 2982, 1733, 1713, 1510, 1445, 1367, 1249, 1149, 1090, 1020, 768 cm-1. HRMS (ESI) m/z: [M+H]+ Calcd for C7H10NO2S 172.0427; Found 172.0421.
34%	In ethanol; at 80℃; for 6.0h;	To asolution of ethyl 2-amino-2-thioxoacetate (2.0 g, 15.0 mol) in ethanol (20 mL) was added chloroacetone (3.6 mL, 45.2 mmol). The reaction mixture was stirred at 80 C for 6 h. The resulting solution was concentrated and purified by column chromatography on silica gel (hexane/ethyl acetate = 4:1) to afford ethyl 4-methylthiazole-2-carboxylate (884 mg, 34%) as yellow solid; 1H-NMR(400 MHz, CDCl3) delta 7.09 (d, J= 0.92, 1H), 4.36-4.31(q, J = 7.16,3H), 2.41 (d, J = 0.92, 1H),1.32-1.28 (t, J =7.16, 2H).
	In ethanol; at 80℃; for 2.0h;	To a solution of ethyl thiooxamate (266 mg, 2.0 mmol) in EtOH (5 ml) is added chloroacetone(116 mg, 2.0 mmol). The reaction mixture is stirred at 80C for 2 hr. The solvent is removed and the resulting residue is purified by PTLC to give the title compound.

In ethanol; at 20℃;Inert atmosphere;

A solution of ethyl amino(thioxo)acetate (500 mg, 3.75 mmol) in ethanol (9.387 ml) was stirred at room temperature under an atmosphere of argon. 1-Chloro-2- propanone (0.299 ml, 3.75 mmol) was added and the solution was heated to reflux for 48 hours. The solution was allowed to cool to room temperature and then it was concentrated under reduced pressure to give a yellow coloured oily solid. The residue was chromatographed [SiO2, 0-100% EtOAc in Hexane] to give a yellow coloured oil identified as product in 208mg. LCMS m/z 171.99 [M+H] (at) 0.79 min (2 min run).

Reference： [1]Tetrahedron Letters,2017,vol. 58,p. 3512 - 3516
[2]Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,p. 140 - 144
[3]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1953,vol. 73,p. 126
Chem.Abstr.,1953,p. 12358
[4]Patent: WO2006/89076,2006,A2 .Location in patent: Page/Page column 46
[5]Patent: WO2010/125102,2010,A1 .Location in patent: Page/Page column 119
[6]Patent: US2341687,1941,

5
[ 16982-21-1 ]
[ 598-31-2 ]
[ 7210-73-3 ]

Reference： [1]Journal of medicinal and pharmaceutical chemistry,1959,vol. 1,p. 577,594

6
[ 7210-73-3 ]
[ 1485-91-2 ]
[ 16914-23-1 ]

Reference： [1]Journal of the Chemical Society C: Organic,1967,p. 1269 - 1273

7
[ 7210-73-3 ]
[ 80-48-8 ]
[ 16914-25-3 ]

Reference： [1]Journal of the Chemical Society C: Organic,1967,p. 1269 - 1273

8
[ 7210-73-3 ]
[ 100-46-9 ]
N-benzyl-4-methylthiazole-2-carboxamide [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1993,p. 675 - 680

9
[ 7210-73-3 ]
[ 78502-74-6 ]
[ 78502-75-7 ]
[ 78502-76-8 ]

Reference： [1]Liebigs Annalen der Chemie,1981,p. 623 - 632
[2]Liebigs Annalen der Chemie,1981,p. 623 - 632

10
[ 7210-73-3 ]
[ 78502-75-7 ]
[ 78502-76-8 ]

Reference： [1]Liebigs Annalen der Chemie,1981,p. 623 - 632

11
[ 16982-21-1 ]
[ 67-64-1 ]
[ 7210-73-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1981,p. 2335 - 2339

12
[ 7210-73-3 ]
[ 13750-63-5 ]

Yield	Reaction Conditions	Operation in experiment
60%		Method B: Alternatively, dissolve 4-methyl-thiazole-2-carboxylic acid ethyl ester (prepare in 27% yield according to the procedures essentially as described in Erlenmeyer, H., et al., HeIv. CHm. Acta (1944), 27, 1437-1438) (1.52 g, 8.88 mmol) in THF (6OmL) and add lithium borohydride (2.0M solution in THF, 9 mL, 17.8 EPO <DP n="136"/>mmol). Heat at reflux temperature for 18 h. Allow to cool to room temperature and dilute the reaction mixture with water (20 mL). Extract into ethyl acetate (3 x 50 mL). Dry the combined organic portions (MgSO4), filter, and concentrate in vacuo at 45 0C. Purify the crude product on silica gel (40 g) with 40 - 80% EtOAc/hexanes to give 690 mg (60%) of the title compound as a colorless oil.

Reference： [1]Patent: WO2007/2181,2007,A2 .Location in patent: Page/Page column 134-145

13
[ 7210-73-3 ]
[ 883-34-1 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1993,p. 675 - 680

14
[ 7210-73-3 ]
[ 14542-15-5 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1981,p. 2335 - 2339

15
[ 7210-73-3 ]
[ 13750-68-0 ]

Reference： [1]Journal of medicinal and pharmaceutical chemistry,1959,vol. 1,p. 577,594

16
[ 7210-73-3 ]
[ 103989-44-2 ]

Reference： [1]Journal of medicinal and pharmaceutical chemistry,1959,vol. 1,p. 577,594

17
[ 7210-73-3 ]
[ 79247-80-6 ]

Yield	Reaction Conditions	Operation in experiment
56%	With N-Bromosuccinimide; In acetonitrile; for 18.0h;Inert atmosphere; Reflux;	To a solution of <strong>[7210-73-3]ethyl 4-methylthiazole-2-carboxylate</strong> (0.594 g, 3.47 mmol) in CH3CN (20 mL) was added N-bromosuccinimide (1.853 g, 10.4 mmol). The mixture solution was stirred for 18 h under refluxing conditions. After being cooled to room temperature, the reaction mixture was added CHCl3 (40 mL), and was washed with H2O (10 mL × 3) and brine (10 mL). The organic layer was dried with MgSO4. After filtration and evaporation, the residue was subject to column chromatography on SiO2 (hexane : EtOAc = 2 : 1) to ethyl 5-bromo-4-methylthiazole-2-carboxylate (0.486 g, 1.94 mmol, 56%) as white solid: m.p. = 32 C, 1H NMR (300 MHz, CDCl3) delta 1.43 (t, J = 7.1 Hz, 3H), 2.50 (s, 3H), 4.47 (q, J = 7.1 Hz, 2H); 13C NMR (75 MHz, CDCl3) delta 14.2, 15.8, 62.7, 112.1, 154.6, 156.7, 159.3; IR (NaCl plate) 1744, 1706, 1507, 1444, 1309, 1098, 111, 756, 631 cm-1. HRMS (ESI) m/z: [M+H]+ Calcd for C7H9BrNO2S 249.9532; Found 249.9526.
50.5%	With N-Bromosuccinimide; In acetonitrile; at 50 - 60℃;Inert atmosphere;	PREPARATION 84Ethyl 5-bromo-4-methylthiazole-2-carboxylateThe reaction solution of <strong>[7210-73-3]ethyl 4-methylthiazole-2-carboxylate</strong> of preparation 83 (240 mg, 1.40 mmol), NBS (277 mg, 1.14 mmol) in CH3CN (5 mL) was heated at 50C for overnight under nitrogen. ~20% starting material was present by LCMS. Additional portion of NBS (70 mg) was added. The reaction solution was heated at 60C for 4 hr, diluted with EtOAc (30 ml), washed with water (2 x 20 mL), brine, dried over sodium sulfate and purified with a silica gel column by ISCO CombiFlash chromatography eluting with 0%-20% EtOAc/Heptane to give the title compound as a yellowish oil (177 mg, 50.5%).1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.37 - 1.44 (m, 3 H), 2.49 (s, 3 H), 4.38 - 4.50 (m, 2 H). MS: ESI+ m/z 250 [MH]+.
	With N-Bromosuccinimide; In acetonitrile; at 20℃; for 5.0h;	To a solution of <strong>[7210-73-3]4-methyl-thiazole-2-carboxylic acid ethyl ester</strong> (171 mg, 1.0 mmol) in acetonitrile (5 ml) is added NBS (180 mg, 1.0 mmol). The reaction mixture is stirred at rt for 2 hr followed by the addition of a second portion of NBS (180 mg, 1.0 mmol). After stirring at rt for 3 hr, the solvent is removed. The resulting residue is purified by PTLC to give the title compound.

Reference： [1]Tetrahedron Letters,2017,vol. 58,p. 3512 - 3516
[2]Patent: WO2011/138751,2011,A2 .Location in patent: Page/Page column 102
[3]Patent: WO2006/89076,2006,A2 .Location in patent: Page/Page column 46

18
[ 7210-73-3 ]
N-((1s,4s)-4-aminocyclohexyl)-2-(3'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-4'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamide [ No CAS ]
N-((1s,4s)-4-(2-(3'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)4'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 88N-CCls^sJ^-Cl-CS'-CCCSS^RJ-S^-dimethylpiperazin-l-yOmethyO^'-hydroxybiphenyl-S- yloxy)-5-fluoronicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide Under an atmosphere of nitrogen and at RT, to a solution of N-((ls,4s)-4-aminocyclohexyl)- 2-(3'-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)-4'-hydroxybiphenyl-3-yloxy)-5- <n="149"/>fluoronicotinamide (0.07 g, 0.13 mmol) in dry DCE (1 mL) was slowly added trimethylaluminum (0.192 mL, 0.38 mmol) (2M in heptane). After being stirred at RT for 15 min (Caution. methane gas is produced), <strong>[7210-73-3]ethyl 4-methylthiazole-2-carboxylate</strong> (0.022 g, 0.13 mmol) was added. The mixture was then stirred in a microwave (CEM Discover) at 800C for 1 h. The reaction was then carefully quenched by the addition of aqueous HCl (IM, 10 mL) followed by dilution with DCM (20 mL). The organic phase was then dried over MgSO4 and then concentrated to give the crude amide. The crude amide was redissolved in methanol and purified by preparative HPLC on a Phenomenex Gemini column using a 95-5% gradient of aqueous 0.1% TFA in acetonitrile as eluent. The fractions containing the desired compound were freeze dried to afford the title compound as a white solid. Yield: 10 mg 1H NMR (500 MHz, DMSO) delta 8.31 (d, J= 7.1 Hz, IH), 8.26 (d, J= 3.1 Hz, IH), 8.07 - 8.03 (m, 2H), 7.59 (s, 2H), 7.49 - 7.44 (m, 2H), 7.37 (s, IH), 7.14 (d, J= 13.9 Hz, IH), 4.01 - 3.98 (m, IH), 3.88 - 3.84 (m, IH), 3.37 (s, 2H), 2.66 - 2.62 (m, 2H), 2.50 - 2.50 (m, 7H), 2.41 (s, 3H), 2.38 - 2.35 (m, IH), 1.83 - 1.79 (m, 4H), 1.69 - 1.66 (m, 4H), 1.18 (d, J= 6.4 Hz, 6H). MS: [M+H]+=673.2 (calc=673.2972) (MultiMode+)

Reference： [1]Patent: WO2009/144494,2009,A1 .Location in patent: Page/Page column 147-148

19
[ 7210-73-3 ]
N-((1s,4s)-4-aminocyclohexyl)-5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamide [ No CAS ]
N-((1s,4s)-4-(5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In ethanol; at 100℃; for 24.0h;Microwave irradiation;	Example 45N-((ls,4s)-4-(5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3- yloxy)nicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide A solution ofN-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(4'-hydroxy-2'- (morpholinomethyl)biphenyl-3-yloxy)nicotinamide (200 mg, 0.34 mmol), ethyl 4- methylthiazole-2-carboxylate (57.7 mg, 0.34 mmol) and triethylamine (0.094 mL, 0.67 mmol) in ethanol (1 mL) was heated to 1000C in a sealed tube in the microwave for 24 h. The mixture was purified using reverse phase preparative HPLC (eluent = MeCN/ NH3(aq)), the appropriate fractions were combined, evaporated to give a white solid which was dried overnight at 400C under vaccum and afforded the title compound. Yield: 23 mg 1H NMR (500 MHz, CD3OD) delta 8.04 (d, J = 3.1 Hz, IH), 8.00 (dd, J = 8.0 Hz, 3.0 Hz, IH), 7.35 (t, J = 7.9 Hz, IH), 7.30 (s, IH), 7.18 - 7.15 (m, IH), 7.11 (d, J = 7.7 Hz, IH), 7.06 (dd, J = 8.0 Hz, 1.7 Hz, IH), 6.97 (d, J = 8.3 Hz, IH), 6.81 (d, J = 2.5 Hz, IH), 6.60 (dd, J = 8.3 Hz, 2.5 Hz, IH), 4.08 - 4.04 (m, IH), 3.92 - 3.87 (m, IH), 3.44 - 3.41 (m, 4H), 3.25 (s, 2H), 2.33 (s, 3H), 2.17 (s, 4H), 1.86 - 1.72 (m, 6H), 1.69 - 1.62 (m, 2H). MS: [M+H]+=646.2 (calc=646.2499) (MultiMode+)

Reference： [1]Patent: WO2009/144494,2009,A1 .Location in patent: Page/Page column 96

20
[ 7210-73-3 ]
[ 1346819-11-1 ]

Reference： [1]Patent: WO2011/138751,2011,A2

21
[ 7210-73-3 ]
[ 1429559-88-5 ]

Reference： [1]Patent: WO2013/50424,2013,A1

22
[ 7210-73-3 ]
[ 1429559-90-9 ]

Reference： [1]Patent: WO2013/50424,2013,A1

23
[ 7210-73-3 ]
[ 1429560-37-1 ]

Reference： [1]Patent: WO2013/50424,2013,A1

24
[ 7210-73-3 ]
[ 1429560-35-9 ]

Reference： [1]Patent: WO2013/50424,2013,A1

25
[ 7210-73-3 ]
[ 1429560-43-9 ]

Reference： [1]Patent: WO2013/50424,2013,A1

26
[ 7210-73-3 ]
N-((1s,4s)-4-aminocyclohexyl)-5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamide dihydrochloride [ No CAS ]
N-((1s,4s)-4-(5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 4661 - 4676

27
[ 7210-73-3 ]
N-((1s,4s)-4-aminocyclohexyl)-2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamide dihydrochloride [ No CAS ]
[ 1610737-03-5 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 4661 - 4676

28
[ 7210-73-3 ]
N-(3-fluorophenyl)-4-methylthiazole-2-carboxamide [ No CAS ]