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Chemical Structure| 7235-40-7 Chemical Structure| 7235-40-7

Structure of β-Carotene
CAS No.: 7235-40-7

Chemical Structure| 7235-40-7

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β-Carotene is a naturally occuring retinol (vitamin A) precursor found in plants and fruits, used to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria.

Synonyms: Provitamin A; beta-Carotene; Solatene

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Product Details of β-Carotene

CAS No. :7235-40-7
Formula : C40H56
M.W : 536.87
SMILES Code : CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1
Synonyms :
Provitamin A; beta-Carotene; Solatene
MDL No. :MFCD00001556
InChI Key :OENHQHLEOONYIE-JLTXGRSLSA-N
Pubchem ID :5280489

Safety of β-Carotene

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat small intestinal crypt epithelial cell line (IEC6) 50 µM 24 hours To investigate the effect of β-carotene on EGF/EGFR bioactivity under LPS-induced inflammatory conditions, it was found that β-carotene pretreatment partially restored the cellular behavior and bioactivity of EGF/EGFR. Cell Cycle. 2022 Aug;21(16):1726-1739

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice LDLR-deficient mice and Bco1-/- mice Dietary supplementation 50 mg/kg 3-4 weeks Β-Carotene accelerates atherosclerosis resolution in a BCO1-dependent manner, increasing regulatory T cells in the plaque Elife. 2024 Feb 6;12:RP87430

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01290250 Overweight Ob... More >>esity Less << Not Applicable Completed - Spain ... More >> Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Spain, 18071 Less <<
NCT01488656 Inflammation Not Applicable Completed - -
NCT01951313 Will Consuming Eggs With a Mix... More >>ed Vegetable Salad Increase Carotenoid Absorption Less << Not Applicable Completed - United States, Indiana ... More >> Purdue University West Lafayette, Indiana, United States, 47907 Less <<
NCT03442283 - Active, not recruiting June 2018 -
NCT01493297 Iron Absorption Not Applicable Completed - Venezuela ... More >> Venezuelan Institute for Scientific Research (IVIC) Caracas, Venezuela, 1020-A Less <<
NCT02276014 Beta-carotene Bioavailability ... More >> Vitamin A Deficiency Less << Not Applicable Completed - United Kingdom ... More >> Newcastle NIHR Clinical Research Facility, Royal Victoria Infirmary Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE1 4LP Less <<
NCT01726127 Dietary Modification Not Applicable Completed - United States, Wisconsin ... More >> University of Wisconsin Osteoporosis Clinical Research Program Clinic Madison, Wisconsin, United States, 53705 Less <<
NCT01628081 Psoriasis Phase 3 Unknown July 2014 Israel ... More >> The Bert W. Strassburger Lipid Center,Sheba Medical Center Recruiting Tel-Hashomer, Israel, 52621 Principal Investigator: Shoshna Greenberger, MD          The Bert W. Strassburger Lipid Center Recruiting Tel-Hashomer, Israel, 52621 Sub-Investigator: Ofir Artzi, MD Less <<
NCT02018692 Retinitis Pigmentosa Phase 1 Phase 2 Not yet recruiting December 31, 2019 Israel ... More >> Goldschleger Eye Research Institute, Sheba Medical Center, Not yet recruiting Tel Hashomer, Israel, 52621 Contact: Ygal Rotenstreich, MD    972-3-530-2880    ygal.rotenstreich@sheba.health.gov.il Less <<
NCT01256697 Retinitis Pigmentosa Not Applicable Completed - Israel ... More >> Sheba Medical Center Tel Hashomer, Israel Less <<
NCT01922713 Vitamin A Deficiency Not Applicable Completed - Zambia ... More >> Center for Human Nutrition Mkushi, Mkushi District, Zambia Less <<
NCT03005496 PreTerm Birth Phase 4 Completed - -
NCT01121081 Psoriasis Phase 3 Withdrawn(no patients enrolled... More >>) Less << January 2012 Israel ... More >> Sheba Medical Center Ramat Gan, Israel, 52621 Less <<
NCT02060279 Pediatric Obesity Not Applicable Completed - United States, Florida ... More >> Nemours Children's Clinic Jacksonville, Florida, United States, 32207 Less <<
NCT00680355 Healthy Not Applicable Completed - United States, Massachusetts ... More >> USDA Human Nutrition Research Center on Aging at Tufts Uni Boston, Massachusetts, United States, 02111 Less <<
NCT03366584 Hyaline Membrane Disease ... More >> Necrotizing Enterocolitis of Newborn Less << Phase 4 Recruiting June 2019 Indonesia ... More >> Cipto Mangunkusumo General Hospital Recruiting Jakarta, DKI Jakarta, Indonesia, 12440 Contact: Yuyun Lisnawati, Consultant    +628161841987    yulisna.er@gmail.com Less <<
NCT01680510 Retinitis Pigmentosa Phase 2 Phase 3 Recruiting December 2018 Israel ... More >> Sheba Medical Center Recruiting Tel Hashomer, Israel, 52621 Contact: Ygal Rotenstreich, Dr.    972-3-5302880       Principal Investigator: Ygal Rotenstreich, Dr. Less <<
NCT02373943 Healthy Not Applicable Completed - Spain ... More >> Hospital Universitari Arnau de Vilanova LLeida, Spain, 25110 Less <<
NCT01477112 Diabetes Mellitus ... More >> Oxidative Stress Iron Metabolism Disorders Less << Not Applicable Completed - Venezuela ... More >> Hospital Baudilio Lara Barquisimeto, Lara, Venezuela Less <<
NCT01695148 Vitamin A Deficiency ... More >> Low Serum Retinol Less << Phase 3 Completed - Zambia ... More >> JHU Office Mkushi, Zambia Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.63mL

3.73mL

1.86mL

References

 

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