Alternatived Products of [ 72758-17-9 ]
Product Details of [ 72758-17-9 ]
CAS No. : | 72758-17-9 |
MDL No. : | N/A |
Formula : |
C11H8Br2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
299.99
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 72758-17-9 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 72758-17-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 72758-17-9 ]
- 1
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[ 14938-58-0 ]
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[ 72758-17-9 ]
- 2
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[ 33295-37-3 ]
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[ 72758-17-9 ]
Yield | Reaction Conditions | Operation in experiment |
96% |
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80℃; for 16h;Inert atmosphere; |
9a (5.00 g, 22.80 mmol) was dissolved in carbon tetrachloride (80 mL), and N-bromosuccinimide (4.50 g, 25.10 mmol) and azobisisobutyronitrile (375 mg, 23.00 mmol) were added. After nitrogen replacement for three times and stirring at 80C for 16 hours, water (50 mL) and ethyl acetate (50 mL) were added to quench the reaction, filtered, and separated. The organic phase was concentrated under reduced pressure to obtain a residue. The residue was subjected to column chromatography (petroleum ether: (Ethyl acetate=0-100%) purification to obtain compound 9b (5.00 g), yield: 96%. |
- 3
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[ 72758-17-9 ]
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[ 85864-82-0 ]
Yield | Reaction Conditions | Operation in experiment |
68% |
With 2-nitropropane; sodium methylate In methanol at 20℃; for 16h; Inert atmosphere; |
9.2 Second step
9b (6.50 g, 21.80 mmol) was dissolved in methanol (100 mL), and 30% sodium methoxide methanol solution (5 mL) and 2-nitropropane (2.91 g, 32.77 mmol) were added. After nitrogen replacement three times, the reaction was carried out at room temperature for 16 hours. Adjust the pH to about 5 with 2N dilute hydrochloric acid, concentrate under reduced pressure to remove methanol, then add water (50 mL) and ethyl acetate (50 mL) and stir, filter, and concentrate under reduced pressure to obtain a residue. The residue is subjected to column chromatography (petroleum ether: Ethyl acetate=0-100%) was purified to obtain compound 9c (3.50g), yield: 68%. |
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