[ CAS No. 727650-61-5 ]

Name: 727650-61-5|3-Aminoquinolin-6-ol|95%
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Product Details of [ 727650-61-5 ]

CAS No. :	727650-61-5	MDL No. :	MFCD18413388
Formula :	C₉H₈N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	160.17 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 727650-61-5 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 727650-61-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 727650-61-5 ]

[ 727650-61-5 ] Synthesis Path-Downstream 1~20

1
[ 24306-33-0 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: bromine; pyridine / tetrachloromethane / 3 h / 0 - 90 °C 2: potassium carbonate; water / methanol / 2 h / 20 °C 3: potassium carbonate / acetone / 20 °C 4: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / Inert atmosphere 5: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
	Multi-step reaction with 5 steps 1: pyridine; bromine / tetrachloromethane / 3 h / 0 - 90 °C 2: potassium carbonate; water / methanol / 1 h / 20 °C 3: potassium carbonate / acetone / 20 °C 4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium <i>tert</i>-butylate / toluene / 8 h / 100 °C / Inert atmosphere 5: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

2
[ 1022151-47-8 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium carbonate; water / methanol / 2 h / 20 °C 2: potassium carbonate / acetone / 20 °C 3: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / Inert atmosphere 4: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
	Multi-step reaction with 4 steps 1: potassium carbonate; water / methanol / 1 h / 20 °C 2: potassium carbonate / acetone / 20 °C 3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium <i>tert</i>-butylate / toluene / 8 h / 100 °C / Inert atmosphere 4: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

3
[ 13669-57-3 ]
[ 727650-61-5 ]

Reference： [1]Synlett,2014,vol. 25,p. 858 - 862
[2]Patent: WO2013/38362,2013,A1
[3]Patent: US2013/245002,2013,A1

4
[ 1337882-50-4 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium <i>tert</i>-butylate / toluene / 8 h / 100 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

5
[ 1427474-53-0 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	With palladium 10% on activated carbon; hydrogen In methanol at 60℃; for 8h;	3-aminoquinolin-6-ol (Q29.ii) 3-aminoquinolin-6-ol (Q29.ii) was obtained by adding to a solution of Q29.i (1.0 g, 2.94 mmol) in MeOH (10 ml), 10% Palladium on carbon (0.313 g, 0.294 mmol), and stirring the reaction mixture under H2 atmosphere (1 atm) at 60°C for 8 h. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to afford the title compound as pale yellow solid (0.5 g, 80% yield). The crude product was used without further purification. LCMS (method B): [M+H]+ = 161 , tR = 0.31 min.
0.5 g	With palladium 10% on activated carbon; hydrogen In methanol at 60℃; for 8h;	3-aminoquinolin-6-ol (Q29.ii) was obtained by adding to a solution of Q29.i (1.0 g, 2.94 mmol) in MeOH (10 ml), 10% Palladium on carbon (0.313 g, 0.294 mmol), and stirring the reaction mixture under H2 atmosphere (1 atm) at 60° C. for 8 h. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to afford the title compound as pale yellow solid (0.5 g, 80% yield). The crude product was used without further purification. LCMS (method B): [M+H]+=161, tR=0.31 min

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1 Location in patent: Page/Page column 101; 102
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1 Location in patent: Paragraph 0846

6
[ 727650-61-5 ]
[ 1427474-56-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 24 h / Reflux 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C 2.2: 3 h / 20 °C
	Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 24 h / Reflux 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 2.2: 3 h / 20 °C

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

7
[ 727650-61-5 ]
[ 1427474-70-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 24 h / Reflux 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C 2.2: 3 h / 20 °C 3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.16 h / 110 °C / Inert atmosphere; Microwave irradiation
	Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 24 h / Reflux 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 2.2: 3 h / 20 °C 3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

8
[ 24424-99-5 ]
[ 727650-61-5 ]
[ 1427474-54-1 ]

Yield	Reaction Conditions	Operation in experiment
0.5 g	In tetrahydrofuran for 24h; Reflux;	tert-butyl 6-hydroxyquinolin-3-ylcarbamate (Q29.iii) To a solution of Q29.N (0.5 g, 3.12 mmol) in THF (10 ml), (Boc)20 (1 .450 ml, 6.24 mmol) was added, and the reaction mixture was stirred at reflux for 24 h. THF was removed under reduced pressure. The residue was dissolved in EtOAc (50 ml), subsequently washed with 1 % HCI solution (10 ml), water (10 ml), sat. 60% NaHCO3 (10 ml) and brine (10 ml). The organic phase was dried over MgS04, filtered and concentrated to afford the crude product as brown oil, which was purified by silica gel chromatography (DCM/MeOH = 30/1 ) to afford the title compound as white solid (0.5 g, 61 .5% yield). LCMS(method B): [M+H]+ = 261 , tR = 2.17 min.
0.5 g	In tetrahydrofuran for 24h; Reflux;	tert-butyl 6-hydroxyquinolin-3-ylcarbamate (Q29.iii) To a solution of Q29.ii (0.5 g, 3.12 mmol) in THF (10 ml), (Boc)2O (1.450 ml, 6.24 mmol) was added, and the reaction mixture was stirred at reflux for 24 h. THF was removed under reduced pressure. The residue was dissolved in EtOAc (50 ml), subsequently washed with 1% HCl solution (10 ml), water (10 ml), sat. 60% NaHCO3 (10 ml) and brine (10 ml). The organic phase was dried over MgSO4, filtered and concentrated to afford the crude product as brown oil, which was purified by silica gel chromatography (DCM/MeOH=30/1) to afford the title compound as white solid (0.5 g, 61.5% yield). LCMS (method B): [M+H]+=261, tR=2.17 min.

9
[ 580-16-5 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: pyridine / dichloromethane / 8 h / 0 - 20 °C 2: bromine; pyridine / tetrachloromethane / 3 h / 0 - 90 °C 3: potassium carbonate; water / methanol / 2 h / 20 °C 4: potassium carbonate / acetone / 20 °C 5: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / Inert atmosphere 6: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
	Multi-step reaction with 6 steps 1: pyridine / dichloromethane / 8 h / 0 - 20 °C 2: pyridine; bromine / tetrachloromethane / 3 h / 0 - 90 °C 3: potassium carbonate; water / methanol / 1 h / 20 °C 4: potassium carbonate / acetone / 20 °C 5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium <i>tert</i>-butylate / toluene / 8 h / 100 °C / Inert atmosphere 6: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2013/38362, 2013, A1
[2]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US2013/245002, 2013, A1

10
[ 727650-61-5 ]
[ 23095-05-8 ]
[ 1451273-43-0 ]

Yield	Reaction Conditions	Operation in experiment
25%	With pyridine at 40℃; for 12h;	IX-1.5 5-Bromo-N-(6-hydroxyquinolin-3-yl)-2-methoxybenzenesulfonamide A solution of 3-aminoquinolin-6-ol (150 mg, 0.9 mmol) and 5-bromo-2- methoxybenzene-l-sulfonyl chloride (143 mg, 0.5 mmol) in pyridine (5 mL) was heated to 40 °C for 12 h. The reaction mixture was concentrated in vacuum and the residue was purified by silica gel column (PE/EtOAc, 10/1) to give 50 mg (yield: 25%) of 5-bromo-N-(6- hydroxyquinolin-3-yl)-2-methoxybenzenesulfonamide as white solid. [00674] 1H NMR (DMSO-d6, 400MHz): δ = 10.59 (1H, brs), 10.06 (1H, brs), 8.42 (1H, s), 7.85 (1H, s), 7.78-7.73 (3H, m), 7.20-7.17 (2H, m), 7.03 (1H, s), 3.85 (3H, s). MS: m/z 409.2 (M+H+).

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1 Location in patent: Paragraph 00673-00674

11
[ 104-94-9 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: hydrogenchloride / water / 0.17 h 1.2: 0.33 h / Inert atmosphere; Reflux 1.3: 50 h / Reflux; Inert atmosphere 2.1: hydrogenchloride; tin(II) chloride hydrate / 0.22 h / 50 °C 3.1: boron tribromide / dichloromethane / 12 h / -60 °C

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

12
[ 159454-73-6 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogenchloride; tin(II) chloride hydrate / 0.22 h / 50 °C 2: boron tribromide / dichloromethane / 12 h / -60 °C

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

13
[ 29507-86-6 ]
[ 727650-61-5 ]

Yield	Reaction Conditions	Operation in experiment
55%	With boron tribromide In dichloromethane at -60℃; for 12h;	IX-1.4 To a vigorously suspension of 6-methoxyquinolin-3 -amine (1.0 g, 5.7 mol) in anhydrous CH2C12 (20 mL) at -60 °C was added BBr3 (3.0 mL) portionwise over 20 minutes. The mixture was stirred vigorously for an additional 12 h and diluted with water to 100 mL. The aqueous layer was extracted with EtOAc (25 mL x3). The extracts were washed brine and dried over Na2S04. The mixture was concentrated to dryness and the residue was purified by silica gel column (DCM/MeOH, 10/1) to give 500 mg (yield: 55%) of 3-aminoquinolin-6-ol as brown solid. MS: m/z 161.1 (M+H+).

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1 Location in patent: Paragraph 00672

14
[ 727650-61-5 ]
[ 1451274-40-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: pyridine / 12 h / 40 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

15
[ 727650-61-5 ]
[ 1451273-46-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: pyridine / 12 h / 40 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 3: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 17 h / 90 °C / 2585.81 Torr

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

16
[ 727650-61-5 ]
[ 1451273-47-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: pyridine / 12 h / 40 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 3: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 17 h / 90 °C / 2585.81 Torr 4: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

17
[ 727650-61-5 ]
[ 1451273-48-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: pyridine / 12 h / 40 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 3: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 17 h / 90 °C / 2585.81 Torr 4: ammonia / water / 2 h / 80 °C

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

18
[ 727650-61-5 ]
[ 1451273-49-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: pyridine / 12 h / 40 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 3: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 17 h / 90 °C / 2585.81 Torr 4: methanol / 2 h / 80 °C

Reference： [1]Current Patent Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE - WO2013/126608, 2013, A1

19
[ 7101-95-3 ]
[ 727650-61-5 ]

Reference： [1]Synlett,2014,vol. 25,p. 858 - 862

20
[ 7101-96-4 ]
[ 727650-61-5 ]

Reference： [1]Synlett,2014,vol. 25,p. 858 - 862

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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P103	Read label before use
Prevention
Code	Phrase
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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Code	Phrase
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P320
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P321
P322
P330	Rinse mouth.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
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P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 727650-61-5 ]

Quality Control of [ 727650-61-5 ]

Related Doc. of [ 727650-61-5 ]

Product Details of [ 727650-61-5 ]

Safety of [ 727650-61-5 ]

Application In Synthesis of [ 727650-61-5 ]

[ 727650-61-5 ] Synthesis Path-Downstream 1~20

Related Functional Groups of [ 727650-61-5 ]

Amines

Alcohols

Related Parent Nucleus of [ 727650-61-5 ]

Quinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 727650-61-5 ]

Related Parent Nucleus of
[ 727650-61-5 ]