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Chemical Structure| 73-66-5 Chemical Structure| 73-66-5

Structure of 73-66-5

Chemical Structure| 73-66-5

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Product Details of [ 73-66-5 ]

CAS No. :73-66-5
Formula : C8H13N3O
M.W : 167.21
SMILES Code : NC1=NC(C)=NC=C1COCC
MDL No. :MFCD00223754

Safety of [ 73-66-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 73-66-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73-66-5 ]

[ 73-66-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 73-66-5 ]
  • [ 2908-71-6 ]
YieldReaction ConditionsOperation in experiment
81% With hydrogen bromide; acetic acid; at 20 - 100℃; for 2.0h; 2-methyl-5-ethoxymethyl-6-aminopyrimidine (1.1 g, 6.6 mmol) was fed to a 200 mL one-neck flask, and then a HBr solution in acetic acid (10%, 73 mL) was added, heated to 100C., and reacted for 2 hrs. The reaction was cooled to room temperature (where during the reaction, the solid was dissolved first, and then a solid was produced gradually). The reaction solution was suctioned, washed with diethyl ether, and recrystallized twice in methanol/anhydrous diethyl ether, to obtain a white solid (1.5 g, yield 81%). 1H NMR (300 MHz, DMSO-d6) delta: 9.31 (s, 1H), 8.62 (s, 1H), 8.50 (s, 1H), 4.67 (s, 2H), 2.49 (s, 3H). MS (ESI): m/z 202 (M+1, 20), 154 (M-Br+OCH3, 100).
 

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