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Chemical Structure| 73183-76-3 Chemical Structure| 73183-76-3

Structure of 73183-76-3

Chemical Structure| 73183-76-3

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Product Details of [ 73183-76-3 ]

CAS No. :73183-76-3
Formula : C21H17N
M.W : 283.37
SMILES Code : CC1(C)C2=CC=CC=C2N3C4=CC=CC=C4C5=CC=CC1=C35

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Application In Synthesis of [ 73183-76-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73183-76-3 ]

[ 73183-76-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 902518-11-0 ]
  • [ 67-64-1 ]
  • [ 73183-76-3 ]
YieldReaction ConditionsOperation in experiment
65% 20 g (62.30 mmol) of Intermediate 1-1 was dissolved in 100 ml of THF, and 24.91 ml (62.30 mmol, 2.5 M in hexane) of n-buLi was slowly added thereto at ?78° C. After stirring for 2 hours, 4.70 ml (80.99 mmol) of acetone was added thereto, and the mixture was slowly heated to room temperature. Then, a NaHCO3 aqueous solution was added thereto, and the mixture was subjected to extraction using MC. The resultant was dried using magnesium sulfate, distilled under reduced pressure, and added to a separate two-neck flask to be mixed with 100 ml of acetic acid. An HCl aqueous solution having the same amount as the catalyst (5 mol percent, 12 N) was added thereto, and the mixture was refluxed while stirring. After 12 hours, the mixture was cooled to room temperature, and distilled water was added thereto. The mixture was subjected to extraction using MC, dried using magnesium sulfate, and distilled under reduced pressure. The resultant was separation-purified using column chromatography to obtain 11.47 g (40.50 mmol, 65percent yield) of Intermediate 1-2.
 

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