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[ CAS No. 73219-89-3 ]

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Chemical Structure| 73219-89-3

Chemical Structure| 73219-89-3

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Quality Control of [ 73219-89-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 73219-89-3 ]

Product Details of [ 73219-89-3 ]

CAS No. :	73219-89-3	MDL No. :	MFCD00052933
Formula :	C₉H₉BrO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CUQANLQRQJHIQE-UHFFFAOYSA-N
M.W :	261.07	Pubchem ID :	2774744
Synonyms :

Safety of [ 73219-89-3 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 73219-89-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 73219-89-3 ]

[ 73219-89-3 ] Synthesis Path-Downstream 1~51

1
[ 1466-76-8 ]
[ 73219-89-3 ]

Yield	Reaction Conditions	Operation in experiment
97%	With bromine In acetic acid for 1.5h;
94%	With sodium hydroxide; N-Bromosuccinimide for 5h; Ambient temperature;
85%	With bromine In 1,4-dioxane; chloroform for 2h; Ambient temperature;

80%	With bromine In chloroform at 0℃; for 1.5h;
	With dioxane*Br₂
	With bromine In 1,4-dioxane; chloroform	1 Example 1. Example 1. 3-Bromo-2,6-dimethoxybenzoic acid A solution of 15 ml of bromine (0.3 mol) in 50 ml of chloroform is added dropwise while stirring and cooling in ice to 54.9 g (0.3 mol) of 2,6-dimethoxybenzoic acid in 150 ml of dioxan. The solution is left at room temperature overnight. The solvent is evaporated and the residue recrystallized from aqueous ethanol. Yield: 59.3 g, m.p. 144°-45° C.

Reference： [1]Cuyegkeng, Maria Assunta; Mannschreck, Albrecht [Chemische Berichte, 1987, vol. 120, p. 803 - 810]
[2]Auerbach, Joseph; Weissman, Steven A.; Blacklock, Thomas J.; Angeles, Marshall R.; Hoogsteen, Karst [Tetrahedron Letters, 1993, vol. 34, # 6, p. 931 - 934]
[3]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]
[4]Chiriboga, Ximena; Gilardoni, Gianluca; Magnaghi, Ilaria; Finzi, Paola Vita; Zanoni, Giuseppe; Vidari, Giovanni [Journal of Natural Products, 2003, vol. 66, # 7, p. 905 - 909]
[5]Doyle,F.P. et al. [Journal of the Chemical Society, 1963, p. 497 - 506]
[6]Current Patent Assignee: ASTRAZENECA PLC - US4232037, 1980, A

2
[ 73219-89-3 ]
[ 84225-91-2 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride for 0.5h; Heating;
	With thionyl chloride
	With thionyl chloride; N,N-dimethyl-formamide In toluene at 65℃; for 1h;

	With thionyl chloride; N,N-dimethyl-formamide In toluene at 50℃; for 1h;
	With thionyl chloride; N,N-dimethyl-formamide In toluene at 60℃; for 1h;
	With thionyl chloride; N,N-dimethyl-formamide In toluene at 65℃; for 2h;

Reference： [1]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]
[2]Kumar; De Paulis; Bengtsson; et al. [European Journal of Medicinal Chemistry, 1986, vol. 21, # 1, p. 1 - 3] Ferranti; Garuti; Giovanninetti; Borgatti; Bartoletti [Archiv der Pharmazie, 1985, vol. 318, # 1, p. 78 - 84]
[3]de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren [Journal of Medicinal Chemistry, 1985, vol. 28, # 9, p. 1263 - 1269]
[4]Cuyegkeng, Maria Assunta; Mannschreck, Albrecht [Chemische Berichte, 1987, vol. 120, p. 803 - 810]
[5]Gawell, Lars; Stroem, Peter; Hoegberg, Thomas [Acta Chemica Scandinavica, 1992, vol. 46, # 10, p. 981 - 984]
[6]Gawell; Hagberg; Hoegberg; Widman [Acta Chemica Scandinavica, 1989, vol. 43, # 5, p. 476 - 480]
[7]Norman, Mark H.; Rigdon, Greg C.; Hall, William R.; Navas III, Frank [Journal of Medicinal Chemistry, 1996, vol. 39, # 5, p. 1172 - 1188]

3
[ 73219-89-3 ]
[ 73219-92-8 ]

Yield	Reaction Conditions	Operation in experiment
80%	With sulfuryl dichloride In chloroform 1.) RT, 12 h, 2.) reflux, 45 min;

Reference： [1]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]

4
[ 73219-89-3 ]
[ 129295-49-4 ]
N-(1-Benzyl-4-methyl-[1,4]diazepan-6-yl)-3-bromo-2,6-dimethoxy-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 5h; Ambient temperature;

Reference： [1]Harada; Morie; Hirokawa; Yoshida; Kato [Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 8, p. 1364 - 1378]

5
[ 73219-89-3 ]
[ 22795-99-9 ]
[ 80125-14-0 ]

Reference： [1]Medicinal Chemistry Research,1996,vol. 6,p. 69 - 80

6
[ 73219-89-3 ]
1-bromo-3-iodo-2,4-dimethoxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With iodine; mercury(II) oxide In nitrobenzene at 160 - 165℃; for 2h;

Reference： [1]Karimi, Farhad; Langstroem, Bengt [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2002, # 20, p. 2256 - 2259]

7
[ 100-42-5 ]
[ 73219-89-3 ]
3-bromo-2,6-dimethoxystilbene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 0.5h;
48%	With palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; p-benzoquinone In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 1h; Inert atmosphere; optical yield given as %de; regioselective reaction;

Reference： [1]Myers, Andrew G.; Tanaka, Daisuke; Mannion, Michael R. [Journal of the American Chemical Society, 2002, vol. 124, # 38, p. 11250 - 11251]
[2]Hu, Peng; Kan, Jian; Su, Weiping; Hong, Maochun [Organic Letters, 2009, vol. 11, # 11, p. 2341 - 2344]

8
[ 930-68-7 ]
[ 73219-89-3 ]
3-(3-bromo-2,6-dimethoxyphenyl)-2-cyclohexen-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	With air; silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 2h;

Reference： [1]Tanaka, Daisuke; Myers, Andrew G. [Organic Letters, 2004, vol. 6, # 3, p. 433 - 436]

9
[ 73219-89-3 ]
[ 586392-15-6 ]

Yield	Reaction Conditions	Operation in experiment
77%	With borane-THF In tetrahydrofuran for 12h; Heating;

Reference： [1]Chiriboga, Ximena; Gilardoni, Gianluca; Magnaghi, Ilaria; Finzi, Paola Vita; Zanoni, Giuseppe; Vidari, Giovanni [Journal of Natural Products, 2003, vol. 66, # 7, p. 905 - 909]

10
[ 696-62-8 ]
[ 73219-89-3 ]
3-bromo-2,4',6-trimethoxybiphenyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With triphenyl-arsane; silver carbonate In dimethyl sulfoxide at 150℃; for 6h;

Reference： [1]Becht, Jean-Michel; Catala, Cedric; Le Drian, Claude; Wagner, Alain [Organic Letters, 2007, vol. 9, # 9, p. 1781 - 1783]

11
[ 73219-89-3 ]
N-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-3-bromo-6-hydroxy-2-methoxybenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SOCl₂, DMF / toluene / 2 h / 65 °C 2: 1.45 g / Et₃N / CHCl₃ / 0.5 h / Heating 3: 0.18 g / 1 N etheral HCl, BBr₃ / CH₂Cl₂ / 0.5 h / Ambient temperature

Reference： [1]Norman, Mark H.; Rigdon, Greg C.; Hall, William R.; Navas III, Frank [Journal of Medicinal Chemistry, 1996, vol. 39, # 5, p. 1172 - 1188]

12
[ 73219-89-3 ]
N-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-3-bromo-2-hydroxy-6-methoxybenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SOCl₂, DMF / toluene / 2 h / 65 °C 2: 1.45 g / Et₃N / CHCl₃ / 0.5 h / Heating 3: 2.06 g / 1 N etheral HCl, BBr₃ / CH₂Cl₂ / 0.5 h / Ambient temperature

Reference： [1]Norman, Mark H.; Rigdon, Greg C.; Hall, William R.; Navas III, Frank [Journal of Medicinal Chemistry, 1996, vol. 39, # 5, p. 1172 - 1188]

13
[ 73219-89-3 ]
N-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-3-bromo-2,6-dimethoxy-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂, DMF / toluene / 2 h / 65 °C 2: 1.45 g / Et₃N / CHCl₃ / 0.5 h / Heating

Reference： [1]Norman, Mark H.; Rigdon, Greg C.; Hall, William R.; Navas III, Frank [Journal of Medicinal Chemistry, 1996, vol. 39, # 5, p. 1172 - 1188]

14
[ 73219-89-3 ]
[ 96947-79-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SOCl₂, DMF / toluene / 1 h / 65 °C 2: 50 percent / CHCl₃ / 0.5 h / 25 °C 3: 50 percent / 3N HCl, BBr₃ / CH₂Cl₂ / 30 h / 20 °C

Reference： [1]de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren [Journal of Medicinal Chemistry, 1985, vol. 28, # 9, p. 1263 - 1269]

15
[ 73219-89-3 ]
[ 96947-80-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SOCl₂, DMF / toluene / 1 h / 65 °C 2: 50 percent / CHCl₃ / 0.5 h / 25 °C 3: 20 percent / 3N HCl, BBr₃ / CH₂Cl₂ / 30 h / 20 °C

Reference： [1]de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren [Journal of Medicinal Chemistry, 1985, vol. 28, # 9, p. 1263 - 1269]

16
[ 73219-89-3 ]
[ 84225-93-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂, DMF / toluene / 1 h / 65 °C 2: 50 percent / CHCl₃ / 0.5 h / 25 °C

Reference： [1]de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren [Journal of Medicinal Chemistry, 1985, vol. 28, # 9, p. 1263 - 1269]

17
[ 73219-89-3 ]
[ 82935-51-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂ / 0.5 h / Heating 2: Et₃N / CHCl₃ / Ambient temperature

Reference： [1]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]

18
[ 73219-89-3 ]
[ 80125-14-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂ / 0.5 h / Heating 2: 10N aq. NaOH / CHCl₃ / 0.17 h / Heating

Reference： [1]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]

19
[ 73219-89-3 ]
[ 89653-83-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 80 percent / SO₂Cl₂ / CHCl₃ / 1.) RT, 12 h, 2.) reflux, 45 min 2: SOCl₂ / 1 h / Heating

Reference： [1]Florvall, Lennart; Oegren, Sven-Ove [Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286]

20
[ 73219-89-3 ]
[ 84225-93-4 ]

Yield	Reaction Conditions	Operation in experiment
79%		10 (-)-N-n-propyl-2-(3-bromo-2,6 -dimethoxybenzamidomethyl)pyrrolidine Example 10 (-)-N-n-propyl-2-(3-bromo-2,6 -dimethoxybenzamidomethyl)pyrrolidine The title compound was prepared from 3-bromo-2,6-dimethoxybenzoic acid via the acylchloride and (-)-1-n-propyl-2-(aminomethyl)pyrrolidine in the same manner as described in Example 8. Yield 79%. M.p. 103°-104° C. [α]D20 =-85.4° (c=0.5; CHCl3).

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US4789683, 1988, A

21
[ 26116-12-1 ]
[ 60-29-7 ]
[ 73219-89-3 ]
[ 73219-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride In toluene; butanone	7 Example 7. Example 7. N-Ethyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine hydrochloride 30 ml of thionyl chloride is added to 17.6 g (0.067 mol) of 3-bromo-2,6-dimethoxybenzoic acid. The mixture is heated on a steam bath for 30 minutes. To the solution is added 50 ml of toluene. The solvent and excess thionyl chloride is evaporated at reduced pressure. The residue is dissolved in 50 ml of dry methyl ethyl ketone. The solution is added dropwise while stirring to 9.23 g (0.072 mol) of 2-(aminomethyl)-1-ethylpyrrolidine in 50 ml of methyl ethyl ketone. After stirring for 30 minutes at room temperature 150 ml of ethyl ether is added. The obtained precipitate is filtered off, washed with ether and recrystallized twice from ethanol-isopropyl ether. Yield: 21.0 g, m.p. 182°-84° C. (first recrystallization). m.p. 184°-85° C. (second recrystallization).

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US4232037, 1980, A

22
(+)-2-(aminomethyl)-1-ethyl-pyrrolidine d-tartrate [ No CAS ]
[ 73219-89-3 ]
[ 73219-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; triethylamine In water	15 Example 15. Example 15. N-Ethyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl) pyrrolidine hydrochloride Using the same method as for compound in Example 14, except of the addition of triethylamine, this compound was prepared from 8.4 g (0.032 mol) of 3-bromo-2,6-dimethoxybenzoic acid, 20 ml of thionyl chloride and 9.0 g (0.032 mol) of (+)-2-(aminomethyl)-1-ethylpyrrolidine d-tartrate. Yield: 7.5 g, m.p. 166°-68° C., [α]D20° =10.7° (0.5% in water).

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US4232037, 1980, A

23
[ 73219-89-3 ]
[ 73219-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; triethylamine In toluene	14 Example 14. Example 14. N-Ethyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl) pyrrolidine hydrochloride 23.8 g (0.09 mol) of 3-bromo-2,6-dimethoxybenzoic acid is heated with 35 ml of thionyl chloride on a steam bath for 30 minutes. After the addition of toluene the excess thionyl chloride is evaporated at reduced pressure. To the residue is added dropwise while stirring a mixture of 12.6 g (0.09 mol) of triethylamine and a chloroform extract prepared as follows: 100 ml of 30% sodium hydroxide solution is added to 25.0 g (0.09 mol) of (-)-2-(aminomethyl)-1-ethylpyrrolidine 1-tartrate.

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US4232037, 1980, A

24
[ 73219-89-3 ]
[ 66003-76-7 ]
[ 1039364-42-5 ]

Yield	Reaction Conditions	Operation in experiment
67%	With silver carbonate; bis[2-(diphenylphosphino)phenyl] ether; palladium dichloride In dimethyl sulfoxide at 150℃; for 1h;

Reference： [1]Becht, Jean-Michel; Le Drian, Claude [Organic Letters, 2008, vol. 10, # 14, p. 3161 - 3164]

25
[ 695-12-5 ]
[ 73219-89-3 ]
[ 1159205-74-9 ]
[ 1159205-73-8 ]
[ 1159205-75-0 ]

Yield	Reaction Conditions	Operation in experiment
	With palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; p-benzoquinone In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 1h; Inert atmosphere; optical yield given as %de; regioselective reaction;

Reference： [1]Hu, Peng; Kan, Jian; Su, Weiping; Hong, Maochun [Organic Letters, 2009, vol. 11, # 11, p. 2341 - 2344]

26
[ 79-24-3 ]
[ 73219-89-3 ]
[ 1242462-16-3 ]

Yield	Reaction Conditions	Operation in experiment
52%	With palladium(II) trifluoroacetate; dimethyl sulfoxide; silver carbonate In 1,4-dioxane at 100℃; for 24h; Inert atmosphere;

Reference： [1]Zhang, Min; Zhou, Jun; Kan, Jian; Wang, Min; Su, Weiping; Hong, Maochun [Chemical Communications, 2010, vol. 46, # 30, p. 5455 - 5457]

27
[ 73219-89-3 ]
[ 106-51-4 ]
[ 1258167-99-5 ]

Yield	Reaction Conditions	Operation in experiment
36%	With palladium diacetate; dimethyl sulfoxide; silver carbonate In N,N-dimethyl-formamide at 120℃; for 3h;

Reference： [1]Location in patent: scheme or table Zhao, Yankai; Zhang, Yuexia; Wang, Jiantao; Li, Huajie; Wu, Longmin; Liu, Zhongquan [Synlett, 2010, # 15, p. 2352 - 2356]

28
[ 73219-89-3 ]
[ 292638-85-8 ]
[ 1253180-88-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	With oxygen; palladium diacetate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 10h; optical yield given as %de; diastereoselective reaction;

Reference： [1]Fu, Zhengjiang; Huang, Shijun; Su, Weiping; Hong, Maochun [Organic Letters, 2010, vol. 12, # 21, p. 4992 - 4995]

29
[ 73219-89-3 ]
[ 75-05-8 ]
[ 1259663-52-9 ]

Yield	Reaction Conditions	Operation in experiment
61%	With palladium(II) trifluoroacetate; 6-methyl-2,2'-bipyridine In water at 130℃; for 1h; Microwave irradiation;

Reference： [1]Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats [Angewandte Chemie - International Edition, 2010, vol. 49, # 42, p. 7733 - 7737]

30
[ 73219-89-3 ]
[ 106-95-6 ]
[ 1269809-26-8 ]

Yield	Reaction Conditions	Operation in experiment
60%	With copper(I) oxide; palladium diacetate; dimethyl sulfoxide; silver carbonate In toluene at 110℃; for 2h; chemoselective reaction;

Reference： [1]Wang, Jiantao; Cui, Zili; Zhang, Yuexia; Li, Huajie; Wu, Long-Min; Liu, Zhongquan [Organic and Biomolecular Chemistry, 2011, vol. 9, # 3, p. 663 - 666]

31
[ 73219-89-3 ]
[ 149104-90-5 ]
[ 1262967-35-0 ]

Yield	Reaction Conditions	Operation in experiment
66%	With copper(II) bis(trifluoromethanesulfonate); silver carbonate In dimethyl sulfoxide at 120℃; for 2h; Sealed vial;

Reference： [1]Dai, Jian-Jun; Liu, Jing-Hui; Luo, Dong-Fen; Liu, Lei [Chemical Communications, 2011, vol. 47, # 2, p. 677 - 679]

32
[ 73219-89-3 ]
[ 89337-62-2 ]
[ 1262097-86-8 ]
[ 1262097-87-9 ]

Yield	Reaction Conditions	Operation in experiment
1: 11% 2: 26%	With N,N-diphenylaminobenzene; oxygen; palladium diacetate In dimethyl sulfoxide; N,N-dimethyl-formamide at 90℃; for 24h; Molecular sieve; optical yield given as %de;

Reference： [1]Fu, Zhengjiang; Huang, Shijun; Kan, Jian; Su, Weiping; Hong, Maochun [Dalton Transactions, 2010, vol. 39, # 47, p. 11317 - 11321]

33
[ 73219-89-3 ]
[ 2873-29-2 ]
[ 1323988-61-9 ]

Yield	Reaction Conditions	Operation in experiment
43%	With palladium diacetate; triphenylphosphine; silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 80℃; for 48h; Inert atmosphere; stereoselective reaction;

Reference： [1]Xiang, Shaohua; Cai, Shuting; Zeng, Jing; Liu, Xue-Wei [Organic Letters, 2011, vol. 13, # 17, p. 4608 - 4611]

34
[ 73219-89-3 ]
[ 4098-06-0 ]
[ 1323988-65-3 ]

Yield	Reaction Conditions	Operation in experiment
47%	With palladium diacetate; triphenylphosphine; silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 80℃; for 48h; Inert atmosphere; stereoselective reaction;

Reference： [1]Xiang, Shaohua; Cai, Shuting; Zeng, Jing; Liu, Xue-Wei [Organic Letters, 2011, vol. 13, # 17, p. 4608 - 4611]

35
[ 96-43-5 ]
[ 73219-89-3 ]
[ 1356488-33-9 ]

Yield	Reaction Conditions	Operation in experiment
40%	With palladium(II) trifluoroacetate; silver carbonate; tricyclohexylphosphine In 1,2-dimethoxyethane; dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere;

Reference： [1]Hu, Peng; Zhang, Min; Jie, Xiaoming; Su, Weiping [Angewandte Chemie - International Edition, 2012, vol. 51, # 1, p. 227 - 231]

36
[ 73219-89-3 ]
[ 131667-57-7 ]
[ 1421692-68-3 ]

Yield	Reaction Conditions	Operation in experiment
16%	With silver (II) carbonate; palladium diacetate; propionic acid; triphenylphosphine In N,N-dimethyl-formamide at 80℃; for 24h;

Reference： [1]Gigant, Nicolas; Chausset-Boissarie, Laëtitia; Gillaizeau, Isabelle [Organic Letters, 2013, vol. 15, # 4, p. 816 - 819]

37
[ 111-34-2 ]
[ 73219-89-3 ]
C₁₄H₁₉BrO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
41%	With palladium(II) trifluoroacetate; p-benzoquinone; 6-methyl-2,2'-bipyridine In N,N-dimethyl-formamide at 120℃; for 24h; regioselective reaction;

Reference： [1]Fardost, Ashkan; Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats [Advanced Synthesis and Catalysis, 2014, vol. 356, # 4, p. 870 - 878]

38
[ 3195-78-6 ]
[ 73219-89-3 ]
N-(1-(3-bromo-2,6-dimethoxyphenyl)vinyl)-N-methylacetamide [ No CAS ]

Reference： [1]Advanced Synthesis and Catalysis,2014,vol. 356,p. 870 - 878

39
[ 88-12-0 ]
[ 73219-89-3 ]
1-(1-(3-bromo-2,6-dimethoxyphenyl)vinyl)pyrrolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53%	With palladium(II) trifluoroacetate; p-benzoquinone; 6-methyl-2,2'-bipyridine In N,N-dimethyl-formamide at 120℃; for 24h; regioselective reaction;

Reference： [1]Fardost, Ashkan; Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats [Advanced Synthesis and Catalysis, 2014, vol. 356, # 4, p. 870 - 878]

40
[ 2235-00-9 ]
[ 73219-89-3 ]
1-(1-(3-bromo-2,6-dimethoxyphenyl)vinyl)azepan-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25%	With palladium(II) trifluoroacetate; p-benzoquinone; 6-methyl-2,2'-bipyridine In N,N-dimethyl-formamide at 120℃; for 24h; regioselective reaction;

Reference： [1]Fardost, Ashkan; Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats [Advanced Synthesis and Catalysis, 2014, vol. 356, # 4, p. 870 - 878]

41
[ 7748-07-4 ]
[ 73219-89-3 ]
C₁₃H₁₇BrO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
21%	With palladium(II) trifluoroacetate; p-benzoquinone; 6-methyl-2,2'-bipyridine In N,N-dimethyl-formamide at 120℃; for 24h; regioselective reaction;

Reference： [1]Fardost, Ashkan; Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats [Advanced Synthesis and Catalysis, 2014, vol. 356, # 4, p. 870 - 878]

42
[ 617-90-3 ]
[ 73219-89-3 ]
[ 206348-24-5 ]

Yield	Reaction Conditions	Operation in experiment
50%	With Pd⁽²⁺⁾*2C₅F₉O₂^(1-); trifluoroacetic acid; 6-methyl-2,2'-bipyridine In tetrahydrofuran; water at 130℃; for 1h; Microwave irradiation;	Procedure for the synthesis of ketone 3q, 3y, 3ad,Table 3 conditions [b] General procedure: A 2 mL microwave vialwas charged with 6-methyl-2,2'-bipyridine (16.3 mg, 0.096 mmol), Pd(O2CCF3)2(26.6 mg, 0.08 mmol) and 500 µL THF. After stirring at room temperature for 5minutes, 3-bromo-2,6-dimethoxybenzoic acid (261.1 mg, 1 mmol), nitrile (5mmol), water (50 µL) and TFA (77 µL, 1 mmol) were added and the mixture heated inthe microwave for 1 hour at 130 °C. Themixture was diluted with DCM (15 mL) and 0.1 M NaOH (15 mL), the phases wereseparated and extracted with DCM (2 ×15 mL), dried with Na2SO4, filtered and concentratedunder reduced pressure. Purification by flash chromatography afforded ketones 3q,3y or 3ad in the yields statedin Table 3.

Reference： [1]Axelsson, Linda; Veron, Jean-Baptiste; Sävmarker, Jonas; Lindh, Jonas; Odell, Luke R.; Larhed, Mats [Tetrahedron Letters, 2014, vol. 55, # 15, p. 2376 - 2380]

43
[ 100-54-9 ]
[ 73219-89-3 ]
[ 1600514-96-2 ]

Yield	Reaction Conditions	Operation in experiment
19%	With Pd⁽²⁺⁾*2C₅F₉O₂^(1-); trifluoroacetic acid; 6-methyl-2,2'-bipyridine In tetrahydrofuran; water at 130℃; for 1h; Microwave irradiation;	Procedure for the synthesis of ketone 3q, 3y, 3ad,Table 3 conditions [b] General procedure: A 2 mL microwave vialwas charged with 6-methyl-2,2'-bipyridine (16.3 mg, 0.096 mmol), Pd(O2CCF3)2(26.6 mg, 0.08 mmol) and 500 µL THF. After stirring at room temperature for 5minutes, 3-bromo-2,6-dimethoxybenzoic acid (261.1 mg, 1 mmol), nitrile (5mmol), water (50 µL) and TFA (77 µL, 1 mmol) were added and the mixture heated inthe microwave for 1 hour at 130 °C. Themixture was diluted with DCM (15 mL) and 0.1 M NaOH (15 mL), the phases wereseparated and extracted with DCM (2 ×15 mL), dried with Na2SO4, filtered and concentratedunder reduced pressure. Purification by flash chromatography afforded ketones 3q,3y or 3ad in the yields statedin Table 3.

Reference： [1]Axelsson, Linda; Veron, Jean-Baptiste; Sävmarker, Jonas; Lindh, Jonas; Odell, Luke R.; Larhed, Mats [Tetrahedron Letters, 2014, vol. 55, # 15, p. 2376 - 2380]

44
[ 73219-89-3 ]
[ 140-29-4 ]
[ 1600514-88-2 ]

Yield	Reaction Conditions	Operation in experiment
68%	With Pd⁽²⁺⁾*2C₅F₉O₂^(1-); trifluoroacetic acid; 6-methyl-2,2'-bipyridine In tetrahydrofuran; water at 130℃; for 1h; Microwave irradiation;	Procedure for the synthesis of ketone 3q, 3y, 3ad,Table 3 conditions [b] General procedure: A 2 mL microwave vialwas charged with 6-methyl-2,2'-bipyridine (16.3 mg, 0.096 mmol), Pd(O2CCF3)2(26.6 mg, 0.08 mmol) and 500 µL THF. After stirring at room temperature for 5minutes, 3-bromo-2,6-dimethoxybenzoic acid (261.1 mg, 1 mmol), nitrile (5mmol), water (50 µL) and TFA (77 µL, 1 mmol) were added and the mixture heated inthe microwave for 1 hour at 130 °C. Themixture was diluted with DCM (15 mL) and 0.1 M NaOH (15 mL), the phases wereseparated and extracted with DCM (2 ×15 mL), dried with Na2SO4, filtered and concentratedunder reduced pressure. Purification by flash chromatography afforded ketones 3q,3y or 3ad in the yields statedin Table 3.

Reference： [1]Axelsson, Linda; Veron, Jean-Baptiste; Sävmarker, Jonas; Lindh, Jonas; Odell, Luke R.; Larhed, Mats [Tetrahedron Letters, 2014, vol. 55, # 15, p. 2376 - 2380]

45
[ 16532-79-9 ]
[ 73219-89-3 ]
[ 1600514-91-7 ]

Yield	Reaction Conditions	Operation in experiment
73%	With Pd⁽²⁺⁾*2C₅F₉O₂^(1-); trifluoroacetic acid; 6-methyl-2,2'-bipyridine In tetrahydrofuran; water at 130℃; for 1h; Microwave irradiation;	Procedure for the synthesis of ketone 3u, 3yand 3ad, Table 3 conditions [d] General procedure: A 2 mL microwave vialwas charged with 6-methyl-2,2'-bipyridine (16.3 mg, 0.096 mmol), Pd(O2CCF3)2(26.6 mg, 0.08 mmol) and 500 µL THF. After stirring at room temperature for 5minutes, 3-bromo-2,6-dimethoxybenzoic acid (522.2 mg, 2 mmol), nitrile (1mmol), water (50 µL) and TFA (77 µL, 1 mmol) were added and the mixture heatedin the microwave for 1 hour at 130 °C. The mixture was diluted with DCM (15 mL)and 0.1 M NaOH (15 mL), the phases were separated and extracted with DCM (2 ×15 mL), dried with Na2SO4, filtered and concentrated under reduced pressure. Purificationby flash chromatography afforded ketones 3u,3y or 3ad in the yields stated in Table 3.

Reference： [1]Axelsson, Linda; Veron, Jean-Baptiste; Sävmarker, Jonas; Lindh, Jonas; Odell, Luke R.; Larhed, Mats [Tetrahedron Letters, 2014, vol. 55, # 15, p. 2376 - 2380]

46
[ 14371-10-9 ]
[ 73219-89-3 ]
(Z)-3-(3-bromo-2,6-dimethoxyphenyl)-3-phenylacrylaldehyde [ No CAS ]
(E)-3-(3-bromo-2,6-dimethoxyphenyl)-3-phenylacrylaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
29%	With silver(I) iodate; Tri(p-tolyl)phosphine; palladium dichloride In N,N-dimethyl-formamide at 120℃; for 1h; Sealed tube; Overall yield = 37 %Spectr.; stereoselective reaction;
17%	With silver(I) iodate; Tri(p-tolyl)phosphine; palladium dichloride In tetrahydrofuran at 120℃; for 22h; Sealed tube; Overall yield = 38 %Spectr.; stereoselective reaction;

Reference： [1]Ban, Shu-Rong; Wang, Hai-Ning; Toader, Violeta; Bohle, D. Scott; Li, Chao-Jun [Organic Letters, 2014, vol. 16, # 24, p. 6282 - 6285]
[2]Ban, Shu-Rong; Wang, Hai-Ning; Toader, Violeta; Bohle, D. Scott; Li, Chao-Jun [Organic Letters, 2014, vol. 16, # 24, p. 6282 - 6285]

47
4-methoxy-trans-cinnamaldehyde [ No CAS ]
[ 73219-89-3 ]
(Z)-3-(3-bromo-2,6-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde [ No CAS ]
(E)-3-(3-bromo-2,6-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
21%	With silver(I) iodate; Tri(p-tolyl)phosphine; palladium dichloride In N,N-dimethyl-formamide at 120℃; for 1h; Sealed tube; Overall yield = 30 %Spectr.; stereoselective reaction;
19%	With silver(I) iodate; Tri(p-tolyl)phosphine; palladium dichloride In tetrahydrofuran at 120℃; for 17h; Sealed tube; Overall yield = 32 %Spectr.; stereoselective reaction;

Reference： [1]Ban, Shu-Rong; Wang, Hai-Ning; Toader, Violeta; Bohle, D. Scott; Li, Chao-Jun [Organic Letters, 2014, vol. 16, # 24, p. 6282 - 6285]
[2]Ban, Shu-Rong; Wang, Hai-Ning; Toader, Violeta; Bohle, D. Scott; Li, Chao-Jun [Organic Letters, 2014, vol. 16, # 24, p. 6282 - 6285]

48
[ 73219-89-3 ]
[ 100-39-0 ]
benzyl 3-bromo-2,6-dimethoxybenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12 g	With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 2h;	46.i (i) Benzyl 3-bromo-2,6-dimethoxybenzoate (i) Benzyl 3-bromo-2,6-dimethoxybenzoate Benzyl bromide (5 mL, 42.0 mmol) was added to a thick suspension of 3-bromo-2,6- dimethoxybenzoic acid (9.4 g, 36.0 mmol) and K2C03 (20 g, 145 mmol) in DMF (300 mL). The mixture was heated at 70°C (block temperature 55°C internal) for 2h. The reaction mixture was concentrated in vacuo to circa 20 mL then partitioned between diethyl ether (500 mL) and 20%w/w NaCI soln. (250 mL). The organics were separated, and washed successively with a 10%vol/vol solution of 880 ammonia in water (250 mL) 1 N HCI (250 mL) and sat. NaHCOs (250 mL). The organics were separated, dried (MgSCU), filtered and evaporated to afford the sub-title compound (12 g). 1 H NMR (400 MHz, DMSO-d6) δ 7.68 (d, 1 H), 7.52 - 7.28 (m, 5H), 6.90 (d, 1 H), 5.35 (s, 2H), 3.79 (s, 3H), 3.70 (s, 3H). LCMS m/z 351/353 (M+H)+ (ES+); BP 373/375 (M+Na)+ (ES+)

Reference： [1]Current Patent Assignee: OXULAR LTD - WO2016/51187, 2016, A1 Location in patent: Page/Page column 167

49
[ 73219-89-3 ]
[ 115269-99-3 ]
(E)-N,N-bis(tert-butoxycarbonyl)-3-(3-bromo-2,6-dimethoxyphenyl)prop-2-en-1-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	With palladium(II) trifluoroacetate; silver carbonate In tetrahydrofuran; dimethyl sulfoxide at 100℃; for 8h; Inert atmosphere; stereoselective reaction;	4.2. General procedure for the decarboxylative arylation of olefins with aryl carboxylic acids General procedure: To an oven-dried pressure tube were sequentially added aryl carboxylic acid 1 (0.2 mmol), olefin 2 (0.24 mmol), Pd(TFA)2 (3.33 mg, 5.0 mol%), Ag2CO3 (55.2 mg, 0.2 mmol), THF (2.0 mL) and DMSO (0.10 mL) under nitrogen at room temperature. After degassing three times, the reaction mixture was heated at 100 °C for 8 h, and then was cooled to room temperature. Water (20.0 mL)was added, and the mixture was extracted with ethyl acetate (3 5.0 mL). The combined organic layer was washed with brine, dried over anhydrious Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluant: hexane/ethyl acetate) to give the pure target product.

Reference： [1]Qin, Xubo; Chen, Changjun; Zhang, Lingjuan; Xu, Jianbin; Pan, Yixiao; Zhao, Haoqiang; Han, Jiahong; Li, Huanrong; Xu, Lijin [Tetrahedron, 2017, vol. 73, # 16, p. 2242 - 2249]

50
[ 7065-05-6 ]
[ 73219-89-3 ]
(E)-2-(4-(3-bromo-2,6-dimethoxyphenyl)but-3-en-2-yl)isoindoline-1,3-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With palladium(II) trifluoroacetate; silver carbonate In tetrahydrofuran; dimethyl sulfoxide at 100℃; for 8h; Inert atmosphere; stereoselective reaction;	4.2. General procedure for the decarboxylative arylation of olefins with aryl carboxylic acids General procedure: To an oven-dried pressure tube were sequentially added aryl carboxylic acid 1 (0.2 mmol), olefin 2 (0.24 mmol), Pd(TFA)2 (3.33 mg, 5.0 mol%), Ag2CO3 (55.2 mg, 0.2 mmol), THF (2.0 mL) and DMSO (0.10 mL) under nitrogen at room temperature. After degassing three times, the reaction mixture was heated at 100 °C for 8 h, and then was cooled to room temperature. Water (20.0 mL)was added, and the mixture was extracted with ethyl acetate (3 5.0 mL). The combined organic layer was washed with brine, dried over anhydrious Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluant: hexane/ethyl acetate) to give the pure target product.

Reference： [1]Qin, Xubo; Chen, Changjun; Zhang, Lingjuan; Xu, Jianbin; Pan, Yixiao; Zhao, Haoqiang; Han, Jiahong; Li, Huanrong; Xu, Lijin [Tetrahedron, 2017, vol. 73, # 16, p. 2242 - 2249]

51
[ 2049-80-1 ]
[ 73219-89-3 ]
(E)-diethyl 2-(3-(3-bromo-2,6-dimethoxyphenyl)allyl)malonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With palladium(II) trifluoroacetate; silver carbonate In tetrahydrofuran; dimethyl sulfoxide at 100℃; for 8h; Inert atmosphere; stereoselective reaction;	4.2. General procedure for the decarboxylative arylation of olefins with aryl carboxylic acids General procedure: To an oven-dried pressure tube were sequentially added aryl carboxylic acid 1 (0.2 mmol), olefin 2 (0.24 mmol), Pd(TFA)2 (3.33 mg, 5.0 mol%), Ag2CO3 (55.2 mg, 0.2 mmol), THF (2.0 mL) and DMSO (0.10 mL) under nitrogen at room temperature. After degassing three times, the reaction mixture was heated at 100 °C for 8 h, and then was cooled to room temperature. Water (20.0 mL)was added, and the mixture was extracted with ethyl acetate (3 5.0 mL). The combined organic layer was washed with brine, dried over anhydrious Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluant: hexane/ethyl acetate) to give the pure target product.

Reference： [1]Qin, Xubo; Chen, Changjun; Zhang, Lingjuan; Xu, Jianbin; Pan, Yixiao; Zhao, Haoqiang; Han, Jiahong; Li, Huanrong; Xu, Lijin [Tetrahedron, 2017, vol. 73, # 16, p. 2242 - 2249]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere